A5075942061- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Pharmacogenetics and Drug Metabolism
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Occupational and environmental lung diseases
- Medical Imaging and Pathology Studies
- Transplantation: Methods and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Carcinogens and Genotoxicity Assessment
- Pneumonia and Respiratory Infections
- Eosinophilic Disorders and Syndromes
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Diet and metabolism studies
- Behavioral and Psychological Studies
- Blood Coagulation and Thrombosis Mechanisms
- Allergic Rhinitis and Sensitization
Boehringer Ingelheim (United States)
2016-2025
Marquette University
2024
Boehringer Ingelheim (Taiwan)
2022
Weatherford College
2020
RELX Group (United States)
2020
Boehringer Ingelheim (Australia)
2020
Roche (United States)
2020
GlaxoSmithKline (United States)
2004-2007
GlaxoSmithKline (United Kingdom)
2006
Centre for Inflammation Research
2006
The evolution of diabetes in the male leptin receptor−deficient (fa/fa) Zucker diabetic fatty (ZDF) rat is associated with disruption normal islet architecture, β-cell degranulation, and increased death. It unknown whether these changes precede or develop as a result increasing plasma glucose, death can be prevented. Early intervention thiazolidinediones prevents architecture. To determine specific effects rosiglitazone (RSG) on mass dynamics, fa/fa (obese) +/fa +/+ (lean) rats age 6 weeks...
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Chronic obstructive pulmonary disease (COPD) is believed to result from an abnormal inflammatory response in the lungs noxious particles and gases usually found cigarette smoke.In this study, molecular mechanisms for enhanced proinflammatory cytokine gene transcription COPD were investigated.Lung tissue was examined 56 subjects undergoing resection peripheral lung tumors as follows: current smokers with (n = 14) without 17), ex-smokers 13), nonsmokers 12). The levels of inhibitor...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets biomarker development. We sought to quantify IPF, determine differential protein expression between subjects with controls, examine relationships markers of severity. Methods This study involved 300 patients from IPF-PRO Registry 100 participants without known disease. Plasma collected at...
Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play important roles in the turnover extracellular matrix pathogenesis idiopathic pulmonary fibrosis (IPF). This study aimed to determine utility circulating TIMPs distinguishing patients with IPF from controls explore associations between MMPs/TIMPs measures disease severity IPF.The cohort (n = 300) came IPF-PRO Registry, an observational multicenter registry that was diagnosed or confirmed at enrolling center past 6...
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with variable clinical course and high mortality. We used data from large national US registry of patients IPF to investigate relationships between patient characteristics, including markers severity, mortality.The analysis cohort comprised enrolled in the IPF-PRO Registry its inception on 5 June 2014 26 October 2017. The primary criterion for inclusion this that must be diagnosed or confirmed at enrolling centre within 6 months....
Rationale: Two antifibrotic medications, nintedanib and pirfenidone, have been approved for the treatment of idiopathic pulmonary fibrosis (IPF) in United States. Few data published on use these medications clinical practice.Objectives: To investigate patterns States.Methods: The Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry, a multicenter U.S. registry, has enrolled patients with IPF that was diagnosed or confirmed at enrolling center past 6 months. Data from June 5,...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix in interstitium and progressive functional decline. We hypothesized that integration multi-omics data would identify clinically meaningful molecular endotypes IPF. Methods The IPF-PRO Registry a prospective registry patients with Proteomic transcriptomic (including total RNA [toRNA] microRNA [miRNA]) analyses were performed using blood collected at enrollment. Molecular...
Abstract Background The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether levels of metabolites correlate the presence IPF, severity or risk clinically relevant outcomes among IPF. Methods analyzed enrollment plasma samples from 300 IPF IPF-PRO Registry 100 individuals without known lung using a set targeted metabolomics clinical analyte modules....
Background Prostasin is expressed in the lung epithelium where it regulates fluid and electrolyte balance via sodium channel proteolysis. We investigated whether circulating prostasin levels are associated with presence severity of IPF levels, or changes them, mortality. Methods Patients came from IPF-PRO Registry. Controls without disease had a similar age/sex distribution. was quantified plasma taken at enrollment and, cohort, approximately 6 months post-enrollment, by immunoassay. Linear...
The prognostic value of patterns and quantitative measures lung fibrosis on high-resolution computed tomography (HRCT) in patients identified as having progressive pulmonary (PPF) has not been established. We investigated whether HRCT scores were associated with risk progression PPF. Patients enrolled the ILD-PRO Registry had an interstitial disease (ILD) other than idiopathic fibrosis, reticular abnormality traction bronchiectasis, met criteria for ILD progression. images taken between 24...
Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated nuclear hormone belonging to the steroid receptor superfamily. Previously, present authors have shown that PPAR‐γ agonists inhibit release inflammatory cell survival factors and induce apoptosis <i>in vitro</i>. The aim this study was determine effect two structurally different PPAR in an vivo</i> model lipopolysaccharide (LPS)-induced airway inflammation. Mice were treated with agonists, rosiglitazone or SB...
Airway smooth muscle thickening is a characteristic feature of airway wall remodelling in chronic asthma. We have investigated the role leukotrienes (ASM) and epithelial cell DNA synthesis ASM following repeated allergen exposure Brown Norway rats sensitized to ovalbumin. There was 3 fold increase synthesis, as measured by percentage bromodeoxyuridine (BrdU) incorporation, repeatedly ovalbumin‐exposed (4.1%, 3.6–4.6; mean, 95% c.i.) compared chronically saline‐exposed (1.3%, 0.6–2.1; P...
The liver X receptors (LXRalpha/beta) are part of the nuclear receptor family and believed to regulate cholesterol lipid homeostasis. It has also been suggested that LXR agonists possess anti-inflammatory properties. aim this work was determine effect on innate immune response in human primary lung macrophages a pre-clinical rodent model inflammation. Before profiling impact agonist, we established both lungs expressed LXRalpha/beta. We then used two structurally distinct demonstrate...
o-Hydroxylation of leukotriene B4 (LTB4) has been reported in human and rodent polymorphonuclear leukocytes; preliminary information indicates that this metabolism is cytochrome P-450 dependent.Therefore, these studies were initiated to characterize the P-450-dependent LTB4 other tissues.LTB4 was metabolized by rat hepatic microsomes two products, 20-hydroxy(w)-LTB4 19-hydroxy(w-1)-LTB4.The formation metabolites both oxygen NADPH dependent indicating a monooxygenase(s) responsible for...
A number of model systems have been developed to study the initiating and promoting phases neoplastic development in rat liver. Four these protocols use diethylnitrosamine (DEN) initiation, but employ different methods promotion. The present studies were designed evaluate under standardized laboratory conditions determine their relative ability induce histochemically identifiable γ-glutamyl transpeptidase positive (GGT + ) foci. Studies also performed examine effects four regimens on...
BackgroundLimited data are available on the association between clinically measured disease severity markers and quality of life (QOL) in idiopathic pulmonary fibrosis (IPF). The study examined associations objective metrics QOL a contemporary IPF population.MethodsThis evaluated baseline from patients enrolled multicenter, US-based Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry June 2014 July 2018. Disease included FVC % predicted, diffusing capacity for carbon monoxide (Dlco)...
Abstract Purpose In patients with idiopathic pulmonary fibrosis (IPF), hospitalizations are associated high mortality. We sought to determine in-hospital mortality rates and factors in IPF. Methods Patients IPF were identified from the Premier Healthcare Database, a representative administrative dataset that includes > 20% of hospital discharges US, using an algorithm based on diagnostic codes billing data. used logistic regression analyze associations between patient-, hospital-,...