A5100355182- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Medical Imaging Techniques and Applications
- Systemic Sclerosis and Related Diseases
- Prostate Cancer Treatment and Research
- Tracheal and airway disorders
- COVID-19 diagnosis using AI
- Eosinophilic Disorders and Syndromes
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Renal and related cancers
- Inflammatory Myopathies and Dermatomyositis
- Inhalation and Respiratory Drug Delivery
- Radiation Dose and Imaging
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Airway Management and Intubation Techniques
- Polyomavirus and related diseases
- Radiology practices and education
- Dermatologic Treatments and Research
- Data-Driven Disease Surveillance
Seoul National University
2024
University of Minnesota
2015-2023
University of California, Los Angeles
2008-2020
UCLA Health
2014
UCLA Medical Center
2014
Korea Institute of Ceramic Engineering and Technology
1996
Korea Institute of Science and Technology
1996
Abstract Background and objective Endobronchial valve ( EBV ) therapy is optimized in patients who demonstrate little or no collateral ventilation CV ). The accuracy of the C hartis S ystem visual assessment high‐resolution computerized tomography HRCT fissure completeness by a core radiology laboratory for classifying status was compared evaluating relationship each method with target lobe volume reduction TLVR after placement. Methods Retrospective analysis study population underwent...
<h3>Objectives</h3> Extent of systemic sclerosis (SSc)-related interstitial lung disease (ILD) assessed from thoracic high-resolution CT (HRCT) predicts course, mortality and treatment response. While quantitative HRCT analyses extent fibrosis (QLFib) or total (QILD) are more sensitive reproducible than visual assessments SSc-ILD, these not widely available. This study evaluates the relationship between clinical parameters QLFib QILD scores to identify potential surrogate measures...
Rationale: Lung transplant offers the potential to extend life for patients with idiopathic pulmonary fibrosis (IPF); yet, this therapeutic modality is only available a small proportion of patients. Objectives: To identify clinical characteristics and social determinants health that differentially associate lung compared death in IPF. Methods: We evaluated data from Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry, multicenter U.S. registry IPF was diagnosed or confirmed...
To propose and evaluate a technique for automatic quantification of fissural completeness from chest computed tomography (CT) in database subjects with severe emphysema.Ninety-six CT studies patients emphysema were included. The lungs, fissures lobes automatically segmented. the was calculated as percentage lobar border defined by fissure. score method compared visual consensus read three radiologists using boxplots, rank sum tests ROC analysis.The found 49% (47/96), 15% (14/96) 67% (64/96)...
Lack of classifier robustness is a barrier to widespread adoption computer-aided diagnosis systems for computed tomography (CT). We propose novel Robustness-Driven Feature Selection (RDFS) algorithm that preferentially selects features robust variations in CT technical factors. evaluated RDFS classification fibrotic interstitial lung disease using 3D texture features. CTs were collected 99 adult subjects separated into three datasets: training, multi-reconstruction, testing. Two thoracic...
The purpose of this study was to investigate whether there is evidence that individuals with severe idiopathic pulmonary fibrosis (IPF) have cognitive deficits when compared healthy lungs. Participants completed five neuropsychological tests: Trail Making Test (TMT) A and B, Stroop Color Word (1, 2, 3), Hopkins Verbal Learning Test, Boston Naming Grooved Pegboard additionally, the short form-36 Beck Depression Index. Twelve participants (7 male, mean age 69.3, 9.4 years) comprised IPF group...
The aim is to investigate whether the 12-month quantitative changes in high-resolution CT (HRCT) measures of interstitial lung disease (ILD) are different, and understand how they change, patients with scleroderma-related ILD who receive drug therapy versus placebo.HRCT images were acquired at baseline 12 months 83 participants Scleroderma Lung Study I, a clinical trial comparing treatment oral cyclophosphamide placebo. A computer-aided model was used quantify extent fibrotic reticulation,...
Abstract Background Pragmatic use of the anti-fibrotic medications pirfenidone and nintedanib for idiopathic pulmonary fibrosis (IPF) in United States (US) has not been studied may be different from international settings due to structural differences between health care systems. This study examined relationship patient- site-level characteristics (a) (b) selection. Methods Data Pulmonary Fibrosis Foundation Patient Registry was used perform univariable multivariable regressions with...
The development and evaluation of a computer-aided bone scan analysis technique to quantify changes in tumor burden assess treatment effects prostate cancer clinical trials.We have developed report on commercial fully automated detection (CAD) system. Using this system, images were intensity normalized, then lesions identified segmented by anatomic region-specific thresholding. Detected compared against expert markings the accuracy CAD metrics Bone Scan Lesion Area, Intensity, Count...
Rationale: The Multicenter International Lymphangioleiomyomatosis Efficacy and Safety of Sirolimus (MILES) trial demonstrated that sirolimus stabilized lung function improved measures functional performance quality life in patients with lymphangioleiomyomatosis.The physiologic mechanisms these beneficial actions are incompletely understood.Objectives: To prospectively determine the longitudinal computed tomographic imaging correlates change MILES treated placebo or sirolimus. Methods:We...
Abstract Background Hospitalizations are common among patients with idiopathic pulmonary fibrosis (IPF). We investigated the impact of hospitalizations on outcomes in IPF. Methods The IPF-PRO Registry is an observational US registry that enrolled IPF was diagnosed or confirmed at enrolling center previous 6 months. Associations between patient characteristics and hospitalization, hospitalization mortality, were analyzed using Cox regression models. Results A total 1002 into Registry. Over a...