A5043371485- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Metallic Glasses and Amorphous Alloys
- Medical Imaging Techniques and Applications
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Magnetic confinement fusion research
- Cancer Immunotherapy and Biomarkers
- Intermetallics and Advanced Alloy Properties
- Fusion materials and technologies
- Pancreatic and Hepatic Oncology Research
- RNA and protein synthesis mechanisms
- Photoacoustic and Ultrasonic Imaging
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Diagnosis and Treatment
- Aluminum Alloys Composites Properties
- Reconstructive Facial Surgery Techniques
- bioluminescence and chemiluminescence research
- Genomics and Phylogenetic Studies
University of Iowa Hospitals and Clinics
2022-2024
Yonsei University
2005-2023
University of Iowa
2018-2022
City of Hope
2012-2021
Oak Ridge National Laboratory
2017-2021
Sungae Hospital
2020-2021
Iowa City Public Library
2020
University of Iowa Health Care
2019
State University of New York
2017
Samsung Medical Center
2015-2016
PURPOSE: To compare and evaluate HER-2/neu clinical assay methods. MATERIALS AND METHODS: One hundred seventeen breast cancer specimens with known amplification overexpression status were assayed four different immunohistochemical assays two fluorescence in situ hybridization (FISH) assays. RESULTS: The accuracy of the FISH for gene was high, 97.4% Vysis PathVision (Vysis, Inc, Downers Grove, IL) 95.7% Ventana INFORM (Ventana, Medical Systems, Tucson, AZ). highest obtained R60 polyclonal...
To critically assess the accuracy and reproducibility of human epidermal growth factor receptor type 2 (HER-2) testing in outside/local community-based hospitals versus two centralized reference laboratories its effect on selection women for trastuzumab (Herceptin)-based clinical trials.Breast cancer specimens from 2,600 were prospectively evaluated by fluorescence situ hybridization (FISH) entry into Breast Cancer International Research Group (BCIRG) trials HER-2-directed therapies.HER-2...
Tracking stem cell localization, survival, differentiation, and proliferation after transplantation in living subjects is essential for understanding biology physiology. In this study, we investigated the long-term stability of reporter gene expression an embryonic rat cardiomyoblast line role epigenetic modulation on reversing silencing. Cells were stably transfected with plasmids carrying cytomegalovirus promoter driving firefly luciferase (CMV-Fluc) passaged repeatedly 3-8 months. Within...
The goal of this study was to characterize the relationship between tumor uptake <sup>64</sup>Cu-DOTA-trastuzumab as measured by PET/CT and standard, immunohistochemistry (IHC)-based, histopathologic classification human epidermal growth factor receptor 2 (HER2) status in women with metastatic breast cancer (MBC). <b>Methods:</b> Women biopsy-confirmed MBC not given trastuzumab for mo or more underwent complete staging, including <sup>18</sup>F-FDG PET/CT. Patients were classified...
Microstructural investigations on a series of (Ti70.5Fe29.5)100−xSnx alloys with x=5, 7, and 9 reveal that Sn addition is effective in introducing both structural spatial heterogeneities ultrafine eutectic composites stemming from large temperature difference between two temperatures upon solidification. The microstructural these strongly enhance the room compressive plasticity up to ∼15.7%.
The influence of partial replacement Fe by Ni in (Fe1−xNix)71Nb6B23 (0≤x≤0.5) bulk glassy alloys on the enhancement plasticity has been investigated. increase Ni-to-Fe concentration ratio effectively improves compressive plasticity. (Fe0.5Ni0.5)71Nb6B23 alloy exhibits an enhanced plastic strain ∼4.2%, together with high strength and distinct hardeninglike characteristics, when compared Ni-free Fe71Nb6B23 glass. improved mechanical properties are ascribed to control intrinsic elastic...
Dear Editor, Glioblastoma (GBM), the most aggressive malignant tumour, is increasingly treated with immunotherapy.1-3 The stimulator of interferon genes (STING) pathway4 key to tumour immunity and a studied target for immunotherapy.5 This study explores immune landscape GBM, focusing on spatial relationships between tumour-associated cells (TAICs)6 STING-expressing cells, uncovering patterns linked prognosis. We 14 recurrent GBM patients using protein composition Gene Ontology (GO) analysis...
An engineered antibody fragment (minibody; scFv-CH3γ1 dimer, Mr 80 000) specific for carcinoembryonic antigen (CEA) has previously demonstrated excellent tumor targeting coupled with rapid clearance in vivo. In this study, variable (V) genes from the anti- p185HER-2 10H8 were similarly assembled and expressed. Four constructs made: first, V both orientations (VL-linker-VH VH-linker-VL) as single chain Fvs (scFvs). Then each scFv was fused to human IgG1 CH3 domain, either by a two amino acid...
Pancreatic cancer (PC) hijacks innate cellular processes to promote growth. We hypothesized that PC exploits PD-1/PD-L1 not only avoid immune responses, but directly enhance also checkpoint inhibitors (ICIs) have direct cytotoxicity in PC. sought elucidate therapeutic targeting of PD-1/PD-L1. PD-1 was assessed cells, patient-derived organoids (PDOs), and clinical tissues. Then, cells were exposed PD-L1 evaluate proliferation. To test signaling, MAPK examined. Radio-immunoconjugates with...
We hypothesized that functional imaging with <sup>64</sup>Cu-DOTA-trastuzumab PET/CT would predict the response to antibody–drug conjugate trastuzumab–emtansine (T-DM1). <b>Methods:</b> Ten women metastatic human epidermal growth factor receptor 2–positive breast cancer underwent <sup>18</sup>F-FDG and on days 1 2 before treatment T-DM1. <b>Results:</b> T-DM1–responsive patients had higher uptake than nonresponsive patients. Day minimum SUV<sub>max</sub> (5.6 vs. 2.8, <i>P</i> < 0.02),...
Systematic investigations on the microstructural evolution of a bimodal eutectic (Ti70.5Fe29.5)91Sn9 ultrafine composite containing Ti3Sn dendrites upon compression reveal that local deformation dominates early stage with plastic strain εp=5.8%. After further (εp=10.2%), wavy propagation shear bands indicative dissipation stress is caused by rotation coarse structure along interfaces structure.
Background Although a number of risk factors for fatal stroke are well established in Western populations, this is less true Asian countries, many which have mortality rates that historically high. In prospective study Shanghai, China, we determined whether the same predict as West. We also studied potential dietary associations, particularly those with antioxidants because these been suggested to reduce atherogenesis. Methods and Results Between 1986 1989, 18 244 men aged 45 64 years living...
Replication-competent murine leukemia virus (MLV) vectors can be engineered to achieve high efficiency gene transfer solid tumors in vivo and tumor-restricted replication, however their safety further enhanced by redirecting tropism of the envelope. We have therefore tested targeting capability replicative stability ecotropic amphotropic replication-competent retrovirus (RCR) containing two tandem repeats from immunoglobulin G-binding domain Staphylococcal protein A inserted into...
The imaging of molecular events in the complex physiological interplay between organelles, cells, tissues, and organs whole organism is now more practical through use small-animal technologies. Radionuclide based using single photon emission computed tomography (SPECT) positron (PET) scanners have been used for intracellular enzymes, receptors, transporters, reporter gene expression, cell trafficking small animals such as mice rats. Sensitive cooled charge-coupled device (CCD) cameras which...
A heterostructured Fe71Si15Ti10Cu4 ultrafine composite has been developed. The addition of Cu with large positive enthalpy mixing the main constituent element (Fe) leads to evolution a unique microstructure different length-scale heterogeneities, i.e., formation spherical colonies containing heterogeneity lamellar spacing and precipitation nanoscale multitwinned within α-Fe layers. These macroscopic microscopic structural heterogeneities are able simultaneously achieve high strength...
Analysis with the SOLPS code suite (Schneider R. et al 1992 J. Nucl. Mater. 196 810; Wiesen S. 2015 463 480–4; Bonnin X. 2016 Plasma Fusion Res. 11 1403102) explains differences in pedestal structure associated different ion drift directions DIII-D. Core transport models predict that fusion power scales roughly as square of pressure at top pedestal, so understanding effects determine steady-state operational scenarios is important to help project developed DIII-D ITER and other devices. Both...
Tumor heterogeneity influences the clinical outcome of patients with cancer, and diagnostic method to measure tumor needs be developed. We analyzed genomic features on pairs primary multiple metastatic lymph nodes from six lung cancer using whole-exome sequencing RNA sequencing. Although somatic single-nucleotide variants were shared in metastases, evolution predicted by pattern alterations was matched anatomic location tumors. Four cases exhibited a branched clonal pattern. Lymph acquired...
Abstract The successful validation of theory-based models transport, magnetohydrodynamic stability, heating and current drive, with tokamak measurements over the last 20 years, has laid foundation for a new era where these can be routinely used in ‘predict first’ approach to design predict outcomes experiments on tokamaks today. capability plasma confinement core profiles quantified uncertainty, based multi-machine, international, database experience, will provide confidence that proposed...