A5100650735- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Chemokine receptors and signaling
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metastasis and carcinoma case studies
- Economic and Financial Impacts of Cancer
- Esophageal Cancer Research and Treatment
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Intraperitoneal and Appendiceal Malignancies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
Johns Hopkins University
2019-2025
Johns Hopkins Medicine
2019-2025
Harvard University
2015-2025
Deaconess Hospital
2025
Beth Israel Deaconess Medical Center
2025
Yale University
2021-2024
Markey Cancer Center
2018-2024
University of Kentucky
2018-2024
University of Baltimore
2024
University Health Network
2024
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment urgently needed. We generated a pancreatic patient-derived organoid (PDO) library that recapitulates mutational spectrum transcriptional subtypes of primary cancer. New driver oncogenes were nominated transcriptomic analyses revealed unique clusters. PDOs exhibited heterogeneous responses standard-of-care chemotherapeutics investigational...
Liver metastasis is the predominant cause of colorectal cancer (CRC) related mortality. Chemokines, soluble factors that orchestrate hematopoetic cell movement, have been implicated in directing metastasis, although their clinical relevance CRC has not defined. Our hypothesis was chemokine receptor CXCR4 expressed by a prognostic factor for poor disease outcome.CRC lines (n = 6) and tumor specimens 139) from patients with different American Joint Committee on Cancer (AJCC) stages were...
Inverse probability of treatment weighting is a popular propensity score-based approach to estimate marginal effects in observational studies at risk confounding bias. A major issue when estimating the score presence partially observed covariates. Multiple imputation natural handle missing data on covariates: covariates are imputed and analysis performed each dataset effect. The effect estimates from then combined obtain an overall estimate. We call this method MIte. However, alternative has...
While epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have changed the treatment landscape for EGFR mutant (L858R and ex19del)-driven non-small-cell lung cancer (NSCLC), most patients will eventually develop resistance to TKIs. In case of first- second-generation TKIs, up 60% an T790M mutation, while third-generation irreversible like osimertinib, lead C797S as primary on-target mutation. The development reversible these mutants is often hampered by poor selectivity...
Mutated tumor cells undergo changes in chromatin accessibility and gene expression, resulting aberrant proliferation differentiation, although how this occurs is unclear. HMGA1 regulators are abundant stem oncogenic diverse tissues; however, their role colon tumorigenesis only beginning to emerge. Here, we uncover a previously unknown epigenetic program whereby amplifies Wnt signaling during driven by inflammatory microbiota and/or Adenomatous polyposis coli (Apc) inactivation....
Cell-free DNA circulating in blood is a candidate biomarker for malignant tumors. Unlike uniformly truncated released from apoptotic nondiseased cells, dead cancer cells varies size. We developed novel method to measure the ratio of longer shorter fragments (DNA integrity) serum as potential patients with colorectal (CRC) or periampullary cancers (PACs).Sera 32 CRC (3 stage I, 14 II, 6 III, and 9 IV patients), 19 PACs (2 1 7 51 healthy volunteers were assessed by quantitative real-time PCR...
Pancreatic cancers of the body and tail (BT) appear to have poorer survival compared with head (HD) lesions. We hypothesized that potential disparities in outcome may be related tumor location. Our objective was examine relationship between location survival.The Surveillance, Epidemiology, End Results registry identified 33,752 patients pancreatic adenocarcinoma 6443 who underwent cancer-directed surgery 1988 2004. Differences relationships clinical factors were assessed. Multivariate...
In Brief Objective: To determine the role of chemokine receptor (CR) expression in patients with melanoma and colorectal cancer (CRC) liver metastases. Summary Background Data: Murine vitro models have identified CR as potential factors organ-specific metastasis multiple cancers. Chemokines via their respective receptors been shown to promote cell migration distant organs. Methods: Patients who underwent hepatic surgery for or CRC metastases were assessed. Screening cDNA microarrays...
Abstract Purpose: Somatic B-RAF gene mutation has been identified in many malignancies and detected at a high frequency cutaneous malignant melanoma. However, the significance of (B-RAFmt) terms its prognostic predictive capabilities for treatment response or disease outcome is not known. We hypothesized that circulating serum B-RAFmt (B-RAFsmt) V600E, serum, predicts melanoma patients receiving concurrent biochemotherapy. Experimental Design: A real-time clamp quantitative reverse...
Abstract Background Identification of patients who likely will or not benefit from cytotoxic chemotherapy through the use biomarkers could greatly improve clinical management by better defining appropriate treatment options for patients. microRNAs may be potentially useful that help guide individualized therapy cancer because microRNA expression is dysregulated in cancer. In order to identify miRNA signatures gastric and predicting resistance cisplatin/fluorouracil (CF) chemotherapy, a...
Neoadjuvant therapy has been used to improve survival in operable pancreatic cancer. The authors' objective was compare long-term outcomes patients receiving neoadjuvant versus adjuvant for resectable adenocarcinoma.The California Cancer Surveillance Program Los Angeles County retrospectively identified 458 with nonmetastatic adenocarcinoma who underwent definitive resection and received systemic chemotherapy between 1987 2006. cohort grouped by timing of therapy-neoadjuvant or adjuvant....
Previously assumed to be a select ligand for chemokine receptor CXCR4, CXCL12 is now known activate both CXCR4 and CXCR7. However, very little about the co-expression of these receptors in cancer cells.We used immunohistochemistry determine extent pancreatic tissue samples immunoblotting verify expression cell lines. In culture studies, siRNA was knock down CXCR7, K-Ras β-arrestin -2 prior stimulating cells with CXCL12. Activation mitogen-activated protein kinase pathway (MAPK) assessed...
BACKGROUND: The standard treatment for locally advanced rectal cancer is preoperative cheimoradiation and total mesorectal excision. After surgery, tumors are classified according to the depth of tumor invasion, nodal involvement, regression grade. However, these staging systems do not provide information about distribution residual cells within bowel wall. OBJECTIVE: This study aimed determine in each layer wall specimens. DESIGN: was a secondary analysis data from prospective phase II...
Abstract Bulk analyses of pancreatic ductal adenocarcinoma (PDAC) samples are complicated by the tumor microenvironment (TME), i.e. signals from fibroblasts, endocrine, exocrine, and immune cells. Despite this, we others have established stroma subtypes with prognostic significance. However, understanding underlying driving distinct stromal landscapes is still incomplete. Here integrate 92 single cell RNA-seq seven independent studies to build a reproducible PDAC atlas focus on tumor-TME...
Abstract Histone deacetylation and DNA methylation establish epigenetic modifications, which through chromatin remodeling may result in gene silencing. We hypothesized that chemokine receptors C-C receptor 7 (CCR7) C-X-C 4 (CXCR4) on melanoma cells undergo regulation. investigated whether a histone deacetylase inhibitor demethylating agent influence CCR7 CXCR4 expression cells. Initially, microarray analysis was done to screen changes after treatment with trichostatin A (TSA)...
In light of continued uncertainty regarding postkidney donation medical, psychosocial and socioeconomic outcomes for traditional living donors especially meeting more relaxed acceptance criteria, a was held in September 2010 to (1) review limitations existing data on kidney donors; (2) assess define the need long-term follow-up (3) identify potential system requirements, infrastructure costs donor United States (4) explore practical options future development funding collection, metrics...
Single-arm trial (SAT) data is increasingly reviewed for drug approvals by regulators and Health Technology Assessment (HTA) bodies. Supplementary in the form of external comparators (ECs) can be used to provide clinical context support these evaluations. In this study we characterized HTAs SAT-based submissions, use supplementary EC outcomes from HTA review.HTA Accelerator database was describe submissions with decisions (2011-2019).A total 433 were identified between 2011 2019 a 13-fold...