A5026912020- Mast cells and histamine
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Polyamine Metabolism and Applications
- Cytokine Signaling Pathways and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Zebrafish Biomedical Research Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Neuroscience and Neuropharmacology Research
- T-cell and B-cell Immunology
- Receptor Mechanisms and Signaling
- Trauma and Emergency Care Studies
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- RNA modifications and cancer
- Influenza Virus Research Studies
- Chronic Myeloid Leukemia Treatments
- Chemokine receptors and signaling
- Cardiac Arrest and Resuscitation
- Immune Cell Function and Interaction
- GDF15 and Related Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Emergency and Acute Care Studies
- Nuclear Receptors and Signaling
Johns Hopkins Medicine
2023-2025
Johns Hopkins University
2022-2025
iRobot (United States)
2025
University of Maine
2019-2024
University of Baltimore
2022-2024
Maine Medical Center Research Institute
2019
Tufts University
2019
Maine Medical Center
2018-2019
Bailey Tool & Manufacturing (United States)
2019
Mutated tumor cells undergo changes in chromatin accessibility and gene expression, resulting aberrant proliferation differentiation, although how this occurs is unclear. HMGA1 regulators are abundant stem oncogenic diverse tissues; however, their role colon tumorigenesis only beginning to emerge. Here, we uncover a previously unknown epigenetic program whereby amplifies Wnt signaling during driven by inflammatory microbiota and/or Adenomatous polyposis coli (Apc) inactivation....
Abstract While targeting immune escape has revolutionized cancer therapy, many tumors, such as acute myeloid leukemia (AML), develop strategies to evade a T-cell mediated attack. Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell disorders at high risk for transformation secondary AML (sAML). Leukemic in MPN is almost universally fatal and targetable mechanisms have remained elusive. The High Mobility Group A1 (HMGA1) gene encodes an architectural transcription factor that...
Cetylpyridinium chloride (CPC) is an antimicrobial used in numerous personal care and janitorial products food for human consumption at millimolar concentrations. Minimal information exists on the eukaryotic toxicology of CPC. We have investigated effects CPC signal transduction immune cell type mast cells. Here, we show that inhibits function degranulation with antigen dose-dependence non-cytotoxic doses ∼1000-fold lower than concentrations consumer products. Previously showed disrupts...
Abstract Although High Mobility Group A1 (HMGA1) chromatin regulators are overexpressed in refractory acute myeloid leukemia (AML) and diverse solid tumors, targetable mechanisms underlying HMGA1 remain elusive. is highly expressed stem cells poorly differentiated cancers where it modulates structure to activate developmental gene networks. In AML arising from JAK2V617F myeloproliferative neoplasms (MPN), required for leukemogenesis by inducing transcriptional networks that drive aberrant...
Abstract Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell disorders caused by hyperactive JAK/STAT signaling and increased risk of transformation to acute myeloid leukemia (AML). However, targetable mechanisms driving progression remain elusive therapies ineffective after develops. We discovered that HMGA1 chromatin regulators required for leukemogenesis in JAK2V617F models MPN AML dysregulating transcriptional networks involved proliferation fate (Li et al, Blood 2022)....
Abstract Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic and cleaning solutions. Yet, there minimal published data on CPC effects eukaryotes, immune signaling, health. Previously, we showed that low-micromolar inhibits rat mast cell function by inhibiting antigen (Ag)-stimulated Ca 2+ mobilization, microtubule polymerization, degranulation. In this study, extend the findings to cells (LAD2) present indicating...
Cetylpyridinium chloride (CPC) is a quaternary ammonium antimicrobial used in numerous personal care products, human food, cosmetic and cleaning solutions. Yet, there minimal published data on CPC effects eukaryotes, immune signaling, health. Previously, it was shown that low-micromolar inhibits rat mast cell function by inhibiting antigen (Ag)-stimulated Ca2+ mobilization, microtubule polymerization, degranulation. In the current study, these findings are extended to cells (LAD2); this...
Introduction: The frequency of opioid-related cardiac arrest (ORCA) is increasing across several geographic regions in the United States. Understanding how Maine’s urban and rural areas are affected by ORCA necessary to improving prevention treatment this public health threat. Hypothesis: Patient demographics, clinical features, rurality survival emergency department (ED) admission vary significantly between non-ORCA. Methods: We evaluated National Emergency Medical Services Information...
The following posters were presented as part of the 2018 MMCRI Summer Student Research Program. This program offers undergraduates and medical students a unique opportunity to conduct research in diverse clinical biomedical science fields during summer months. During paid ten-week program, participate mentored independent projects either our state-of-the-art facility, or working with physicians hospital setting impact patient care outcome treatment. Students also attend lectures workshops...
Abstract The COVID-19 pandemic raises significance for a potential influenza therapeutic compound, cetylpyridinium chloride (CPC), which has been extensively used in personal care products as positively-charged quaternary ammonium antibacterial agent. CPC is currently clinical trials to assess its effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity. Two published studies have provided mouse and human data indicating that may alleviate infection, here we show...
Riker, Richard; Nussinow, Tyler; Sawyer, Mary; West, Bailey; Stone, Philip; Eldridge, Ashley; May, Teresa; Seder, David Author Information
Abstract The most recent advance in the treatment of osteosarcoma (OS) occurred 1980s when multi-agent chemotherapy was shown to improve overall survival compared surgery alone. Animal model investigations can accelerate understanding human diseases and since few models are available for OS, we refined a rat ask questions regarding pathways metastasis biomarker predictiveness. outbred Sprague-Dawley (SD) is an immunocompetent, syngeneic model, as implant UMR106 OS cells (ATCC), which were...