A5059768763- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Occupational and environmental lung diseases
- Systemic Sclerosis and Related Diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Transplantation: Methods and Outcomes
- Occupational exposure and asthma
- Sarcoidosis and Beryllium Toxicity Research
- Inhalation and Respiratory Drug Delivery
- Inflammatory Myopathies and Dermatomyositis
- Telomeres, Telomerase, and Senescence
- Biochemical Analysis and Sensing Techniques
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Eosinophilic Disorders and Syndromes
- Pneumonia and Respiratory Infections
- Intensive Care Unit Cognitive Disorders
- Wastewater Treatment and Reuse
- Gastric Cancer Management and Outcomes
- Genomics and Rare Diseases
- Simulation-Based Education in Healthcare
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Adsorption and Cooling Systems
The University of Texas Southwestern Medical Center
2016-2024
Southwestern Medical Center
2020-2024
La Jolla Alcohol Research
2022-2023
Parks Victoria
2022-2023
Nephrologisches Zentrum Goettingen
2022-2023
RELX Group (United States)
2022-2023
Hamilton Health Sciences
2022-2023
Footscray Hospital
2022-2023
Dialyse Centrum Groningen
2022-2023
Cooperative Trials Group for Neuro-Oncology
2022-2023
Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about similarities or differences of affected individuals. 115 patients with telomerase reverse transcriptase ( TERT ) (n=75), RNA component TERC (n=7), regulator telomere elongation helicase 1 RTEL1 (n=14) and poly(A)-specific ribonuclease PARN (n=19) were identified clinical data analysed. Approximately one-half (46%) had a multidisciplinary diagnosis idiopathic fibrosis (IPF);...
Background: The utility of whole-exome sequencing (WES) for the diagnosis and management adult-onset constitutional disorders has not been adequately studied. Genetic diagnostics may be advantageous in adults with chronic kidney disease (CKD), whom cause failure often remains unknown. Objective: To study diagnostic WES a selected referral population CKD. Design: Observational cohort. Setting: A major academic medical center. Patients: 92 CKD unknown or familial nephropathy hypertension....
Rationale: Criteria for progressive pulmonary fibrosis (PPF) have been proposed, but their prognostic value beyond categorical decline in FVC remains unclear. Objectives: To determine whether proposed PPF criteria predict transplant-free survival (TFS) patients with non–idiopathic (IPF) forms of interstitial lung disease (ILD). Methods: A retrospective, multicenter cohort analysis was performed. Patients diagnoses fibrotic connective tissue disease–associated ILD, hypersensitivity...
Leukocyte telomere length (LTL), MUC5B rs35705950 and TOLLIP rs5743890 have been associated with idiopathic pulmonary fibrosis (IPF). In this observational cohort study, we assessed the associations between these genomic markers outcomes of survival rate disease progression in patients interstitial pneumonia autoimmune features (IPAF, n=250) connective tissue disease-associated lung (CTD-ILD, n=248). IPF (n=499) was used as a comparator. The LTL IPAF CTD-ILD (mean age-adjusted...
Patients in intensive care units are at higher risk for development of pressure ulcers than other patients. In order to prevent from developing patients, must be assessed accurately.To evaluate the predictive validity Braden scale assessing patients by using 4 years data electronic health records. Methods Data records admitted between January 1, 2007, and December 31, 2010, were extracted warehouse an academic medical center. Predictive was measured sensitivity, specificity, positive value,...
Immunosuppression was associated with adverse events for patients idiopathic pulmonary fibrosis (IPF) in the PANTHER-IPF (Evaluating Effectiveness of Prednisone, Azathioprine and
Background Proposed criteria for progressive fibrosing interstitial lung disease (PF-ILD) have been linked to increased mortality risk, but function trajectory after satisfying individual remains unknown. Because survival is rarely employed as the primary end-point in therapeutic trials, identifying PF-ILD that best predict subsequent change forced vital capacity (FVC) could improve clinical trial design. Methods A retrospective, multicentre longitudinal cohort analysis was performed...
Rationale: Genetic studies of idiopathic pulmonary fibrosis (IPF) have improved our understanding this disease, but not all causal loci been identified. Objectives: To identify genes enriched with rare deleterious variants in IPF and familial fibrosis. Methods: We performed gene burden analysis whole-exome data, tested single for disease association, conducted KIF15 (kinesin family member 15) functional studies, examined human lung single-cell RNA sequencing data. Measurements Main Results:...
Importance Pulmonary fibrosis (PF) is characterized by progressive scarring of lung tissue and poor survival. Racial ethnic minority populations face the greatest risk morbidity mortality from disparities impacting respiratory health, but pattern age at clinically relevant outcomes across diverse racial with PF unknown. Objective To compare PF-related heterogeneity in survival patterns among Hispanic, non-Hispanic Black, White participants. Design, Setting, Participants This cohort study...
Background Studies suggest a harmful pharmacogenomic interaction exists between short leukocyte telomere length (LTL) and immunosuppressants in idiopathic pulmonary fibrosis (IPF). It remains unknown if similar non-IPF interstitial lung disease (ILD). Methods A retrospective, multicentre cohort analysis was performed fibrotic hypersensitivity pneumonitis (fHP), unclassifiable ILD (uILD) connective tissue (CTD)-ILD patients from five centres. LTL measured by quantitative PCR for discovery...
Abstract Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age mortality across racially diverse PF cohorts. LTL measurements among participants stratified race/ethnicity were assessed in relation to all-cause mortality, compared controls. Generalized linear models used evaluate age-LTL relationship, Cox proportional hazards for hazard ratio estimation, Cochran–Armitage test...
Germline coding mutations in different telomere-related genes have been linked to autosomal-dominant familial pulmonary fibrosis. Individuals with these inherited demonstrate incomplete penetrance of clinical phenotypes affecting the lung, blood, liver, skin, and other organs. Here, we describe somatic acquisition promoter telomerase reverse transcriptase (TERT) blood leukocytes approximately 5% individuals loss-of-function TERT or poly(A)-specific ribonuclease (PARN), another gene function....
Interstitial pneumonia with autoimmune features (IPAF) characterises individuals interstitial lung disease (ILD) and of connective tissue (CTD) who fail to satisfy CTD criteria. Inclusion myositis-specific antibodies (MSAs) in the IPAF criteria has generated controversy, as these patients also meet proposed for an antisynthetase syndrome. Whether MSAs myositis-associated (MAA) identify phenotypically distinct subgroups remains unclear. A multicentre, retrospective investigation was conducted...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with few treatment options. N -acetylcysteine (NAC) well-tolerated, inexpensive antioxidant and anti-fibrotic properties. The National Heart, Lung, Blood Institute (NHLBI)-sponsored PANTHER (Prednisone Azathioprine NAC therapy in IPF) trial confirmed the harmful effects of immunosuppression IPF, did not show benefit to NAC. However, post hoc analysis revealed potential beneficial effect subgroup individuals...