A5072623610- Autophagy in Disease and Therapy
- Behavioral Health and Interventions
- Education and Critical Thinking Development
- Gestational Diabetes Research and Management
- Science Education and Pedagogy
- Impact of Technology on Adolescents
- Migration, Health and Trauma
- Ubiquitin and proteasome pathways
- Palliative Care and End-of-Life Issues
- Reproductive Physiology in Livestock
- Mobile Health and mHealth Applications
- Cellular transport and secretion
- Digital Mental Health Interventions
- Microtubule and mitosis dynamics
- Click Chemistry and Applications
- Ecology and Vegetation Dynamics Studies
- Adolescent Sexual and Reproductive Health
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Protease and Inhibitor Mechanisms
- Nursing Roles and Practices
- Posttraumatic Stress Disorder Research
- Interpreting and Communication in Healthcare
- Stroke Rehabilitation and Recovery
- Medical Education and Admissions
Hunter New England Local Health District
2013-2024
Pacific University Oregon
2021
Committee on Publication Ethics
2021
University of Kentucky
2021
Neighborhood Health
2020
New York University
2020
Henry Street Settlement
2020
Brigham Young University
2018
Georgia State University
2017
University of California, Davis
2015
Methuosis is a novel caspase-independent form of cell death in which massive accumulation vacuoles derived from macropinosomes ultimately causes cells to detach the substratum and rupture. We recently described chalcone-like compound, 3-(2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (i.e., MIPP), can induce methuosis glioblastoma other types cancer cells. Herein, we describe synthesis structure–activity relationships directed library related compounds, providing insights into...
Abstract Background Methuosis is a unique form of non-apoptotic cell death triggered by alterations in the trafficking clathrin-independent endosomes, ultimately leading to extreme vacuolization and rupture cell. Results Here we describe novel chalcone-like molecule, 3-(2- m ethyl-1H- i ndol-3-yl)-1-(4- p yridinyl)-2- ropen-1-one (MIPP) that induces with hallmarks methuosis. MIPP causes rapid accumulation vacuoles derived from macropinosomes, based on time-lapse microscopy labeling...
Germline coding mutations in different telomere-related genes have been linked to autosomal-dominant familial pulmonary fibrosis. Individuals with these inherited demonstrate incomplete penetrance of clinical phenotypes affecting the lung, blood, liver, skin, and other organs. Here, we describe somatic acquisition promoter telomerase reverse transcriptase (TERT) blood leukocytes approximately 5% individuals loss-of-function TERT or poly(A)-specific ribonuclease (PARN), another gene function....
Methuosis is a unique form of nonapoptotic cell death triggered by alterations in the trafficking clathrin-independent endosomes, ultimately leading to extreme vacuolization and rupture cell. can be induced glioblastoma cells expression constitutively active Ras. This study identifies small GTPases, Rac1 Arf6, Arf6 GTPase-activating protein, GIT1, as key downstream components signaling pathway underlying Ras-induced methuosis. The extent which graded H-Ras(G12V) triggers cytoplasmic...
Science education reforms worldwide call on teachers to engage students in investigative approaches instruction, like inquiry. Studies of teacher self-reported enactment indicate that inquiry is used frequently the classroom, suggesting a high level proficiency with would be amenable reform. However, it unclear whether frequency self-report based sound knowledge In absence knowledge, rates suspect. We conducted study measure teachers' as related known, reported enactment. developed...
Self-administered eHealth interventions provide a potential low-cost solution for reducing diabetes risk. The aim of this pilot randomised controlled trial (RCT) was to evaluate the feasibility, including recruitment, retention, preliminary efficacy (primary outcome) and acceptability (secondary “Body Balance Beyond” intervention in women with previous gestational mellitus (GDM). Women overweight/obesity who had recent GDM (previous 24 months) were into one three groups: 1) high...
14-3-3σ regulates cytokinesis and cell cycle arrest induced by DNA damage but its role in the immune system is unknown. Using gene-targeted 14-3-3σ-deficient (i.e., KO) mice, we studied of B-cell functions. Total numbers B cells were reduced spontaneous apoptosis peripheral cells. Upon antigen receptor engagement vitro, KO did not proliferate properly or up-regulate CD86. In response to T cell-independent antigens, showed poor secretion antigen-specific IgM. This deficit led increased...
Two home telehealth technologies (the Intel Health Guide and the Apple iPad) were trialled by four clinical services of Hunter New England Local District. The iPad was selected Paediatric Palliative Care Service, Stroke Service Brain Injury Rehabilitation Service. Cardiac Coaching devices loaned to a total 102 patients for different lengths time, depending on needs, but typically about 3 months. A 42 clinicians involved. During trial, 16 technical problems recorded resolved, most concerning...
Mindfulness meditation has become increasingly popular over the last few years, due in part to increase mobile apps incorporating practice. Although studies have demonstrated potential of mindfulness positively impact health, little been uncovered about what predicts engagement meditation. Understanding predictors may help practitioners and phone app developers improve intervention strategies experience.The purpose this study was use Theory Planned Behavior Temporal Self-Regulation determine...
// Yanhong Zhang 1 , Ashley Young Jin and Xinbin Chen Comparative Oncology Laboratory, Schools of Medicine Veterinary Medicine, University Californian at Davis, CA, USA Correspondence to: Chen, email: Keywords : P73, p21, PUMA, epithelial-to-mesenchymal transition (EMT), MDCK Received March 11, 2015 Accepted June 04, Published 08, Abstract a member p53 tumor suppressor family, plays crucial role in suppression neural development. Due to the usage two promoters, p73 is expressed as isoforms,...
From April 2016 to June 2017, the Health + Housing Project employed four community health workers who engaged residents of two subsidized housing buildings in New York City address individuals' broadly defined needs, including social and economic risk factors. Following intervention, we observed significant improvements residents' food security, ability pay rent, connection primary care. No immediate change was seen acute care use or more narrowly outcomes.
Abstract Background To evaluate the preliminary efficacy, feasibility and acceptability of 3-month Body Balance Beyond (BBB) online program among Australian women with overweight/obesity recent gestational diabetes mellitus. Methods Women were randomised into either: 1) High Personalisation (HP) (access to ‘BBB’ website, video coaching sessions, text message support); 2) Medium (MP) (website or 3) Low (LP) only). Generalised linear mixed models used weight, diet quality, physical activity...
<title>Abstract</title> Background Persistent musculoskeletal pain is the most commonly reported health problem in refugees and asylum seekers. In an Ezidi settlement region Australia, physiotherapy department received a high number of referrals for treatment chronic low back pain. Group programs to manage have been shown be effective general population. However, application this refugee population has not previously reported. Objective We aimed evaluate group program tailored for,...
Refugees experience physical and mental health issues that need attention following settlement in a new community. However, access to utilisation of healthcare services is challenging. We aimed explore the refugee dedicated multi-disciplinary team.
9625 Background: Despite previous studies showing benefits of early referral to palliative care in improving quality cancer care, late and under-utilization are major concerns. The aim this study was determine the impact medicine specialist (EPC) on outcomes advanced lung pts at a comprehensive center. Methods: In prospective non-randomized controlled study, with non-small cell oncologist estimated survival ≤ 6 months were referred EPC, N=51. A control group similar characteristics recruited...