A5007078872- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Gastrointestinal motility and disorders
- Colorectal Cancer Screening and Detection
- Neutropenia and Cancer Infections
- Hemoglobinopathies and Related Disorders
- Acute Myeloid Leukemia Research
- Microscopic Colitis
- Neuroblastoma Research and Treatments
- Inflammatory Bowel Disease
- Gastric Cancer Management and Outcomes
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- Neonatal Health and Biochemistry
- Blood disorders and treatments
- Lymphoma Diagnosis and Treatment
- Congenital gastrointestinal and neural anomalies
- Colorectal Cancer Surgical Treatments
- Adolescent and Pediatric Healthcare
- CAR-T cell therapy research
- Helicobacter pylori-related gastroenterology studies
- Hematopoietic Stem Cell Transplantation
- Gastroesophageal reflux and treatments
- Blood transfusion and management
- Pediatric Pain Management Techniques
UCSF Benioff Children's Hospital
2018-2025
Integral University
2024
UCSF Helen Diller Family Comprehensive Cancer Center
2021-2024
University of California, San Francisco
2021-2024
Bassetlaw Hospital
2021-2023
Frontier Agriculture (United Kingdom)
2023
Doncaster Royal Infirmary
2012-2022
University of San Francisco
2021
Maulana Azad Medical College
2020
Institute of Medical Sciences
2018-2019
Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders seen by clinicians in both primary and secondary care. Since publication last British Society Gastroenterology (BSG) guideline 2007, substantial advances have been made understanding its complex pathophysiology, resulting re-classification as a disorder gut-brain interaction, rather than functional disorder. Moreover, there has considerable amount new evidence published concerning diagnosis,...
Background & AimsAnti–tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce formation of anti-drug antibodies. The ability to identify patients at increased risk development antibodies would facilitate selection therapy and use preventative strategies.MethodsWe performed a genome-wide association study variants associated with time in discovery cohort 1240 biologic-naïve Crohn's disease...
The gut microbiota (GM) consists of resident commensals and transient microbes conveyed by the diet but little is known about role latter on GM homeostasis. Here we show, a conjunction quantitative metagenomics, in silico genome reconstruction metabolic modeling, that consumption fermented milk product containing dairy starters Bifidobacterium animalis potentiates colonic short chain fatty acids production decreases abundance pathobiont Bilophila wadsworthia compared to subjects with...
Functional dyspepsia (FD) is a common disorder of gut-brain interaction, affecting approximately 7% individuals in the community, with most patients managed primary care. The last British Society Gastroenterology (BSG) guideline for management was published 1996. In interim, substantial advances have been made understanding complex pathophysiology FD, and there has considerable amount new evidence concerning its diagnosis classification, advent Rome IV criteria, management. aim this...
BackgroundWe sought to report the effectiveness of infliximab and adalimumab over first 3 years treatment define factors that predict anti-TNF failure strategies prevent or mitigate loss response.MethodsPersonalised Anti-TNF therapy in Crohn's disease (PANTS) is a UK-wide, multicentre, prospective observational cohort study reporting rates anti-TNF-naive patients with active luminal aged 6 older. At end year, sites were invited enrol participants still receiving drug into 2-year...
OBJECTIVES: Patients with irritable bowel syndrome and constipation (IBS-C) show more abdominal distension than do those diarrhea. Because is often associated delayed gastrointestinal transit, this study aimed at establishing whether patients transit bloating normal transit. METHODS: Abdominal girth was recorded for 24 h using inductance plethysmography (AIP) in 30 IBS-C (Rome II criteria) (aged 18-68 years; 27 women) healthy volunteers (21-58 years of age; 26 women). Within 2 weeks...
<h3>Objective</h3> In women presenting to gynaecological clinics with lower abdominal pain, the cause is frequently attributed endometriosis irrespective of whether it found be minimal or extensive at laparoscopy. Irritable bowel syndrome (IBS) also common in this setting, and was speculated that visceral hypersensitivity associated condition might amplifying symptoms endometriosis. <h3>Methods</h3> Visceral sensitivity balloon distension, psychological status were assessed following...
Chimeric antigen receptor T cell (CAR-T) therapy is a promising approach to improve survival for children and adults with relapsed/refractory (r/r) B acute lymphoblastic leukemia (B-ALL), but these clinical trials might not be equally accessible patients of low socioeconomic status (SES) or from racial ethnic minority groups. We sought describe the sociodemographic characteristics pediatric adolescent young adult (AYA) enrolled in CAR-T compare those other r/r B-ALL. conducted multicenter...
Abstract Objective Due to incomplete management of vaso‐occlusive pain episodes (VOE) in patients with sickle cell disease (SCD), we sought determine if immersive VR would be feasible for inpatients. Secondarily, hypothesized that a single session improve the VOE experience. Procedures Consecutive SCD eight years and older admitted were offered one 15‐minute session, utilizing relaxing underwater world specifically created pediatric minimize potential simulator side effects. Safety...
: Frozen shoulder is a progressively restrictive condition characterized by gradual onset of pain, stiffness, and limited mobility in the joint. Among different treatment modalities available, minimally invasive treatments include Suprascapular nerve (SSN) interventions using steroids with local anesthetics pulsed radiofrequencytreatment. This study aims to evaluate whether combining triamcinolone injection radiofrequency can provide more prolonged pain relief compared alone. A comparative...
Abstract Background Non-ischemic cardiomyopathy (NICM) and ischemic (ICM) can both lead to right ventricular (RV) dysfunction. Data on direct head comparisons of the two entities regarding RV size function using state-of-the-art imaging techniques is sparse. Such a comparison may help better understand underlying pathophysiology dysfunction in NICM ICM. Also, differentiation between etiologies for has important therapeutic implications because ICM benefit from coronary revascularization....
Abstract Background There are minimal epidemiological data comparing the burden of disorders gut brain interaction (DGBI) in UK with other countries. We compared prevalence DGBI countries that participated Rome Foundation Global Epidemiology Study (RFGES) online. Methods Participants from 26 completed RFGES survey online including IV diagnostic questionnaire and an in‐depth supplemental questions about dietary habits. sociodemographic were 25 pooled together. Key Results The proportion...
Based on previous reports of disparities in financial burden following a cancer diagnosis, this study aims to characterize mechanisms experienced by caregivers children with cancer, including the impact work flexibility and social support.Cross-sectional survey (in English or Spanish) that assessed household material hardship (HMH), toxicity, income change.Of 156 surveyed, 32% were Hispanic low income. more likely report HMH toxicity compared non-Hispanic White Asian (HMH: 57% vs. 21% 19%, p...
10016 Background: Inotuzumab ozogamicin (InO) is effective in adults and children with relapsed/refractory (R/R) CD22+ B-acute lymphoblastic leukemia (B-ALL). Children’s Oncology Group AALL1732 a phase 3 randomized trial evaluating InO for newly diagnosed patients (pts) high-risk B-ALL. Given known hepatic, hematologic, infectious toxicities, two safety phases were completed. Methods: Pts residual marrow disease < 0.01% by end consolidation are to chemotherapy (Arm A) or plus 2 cycles of...
Abstract Background Families experience financial burden and household material hardship (HMH) after a pediatric cancer diagnosis. This study investigates types of assistance other coping strategies (FCS) adopted by families during the first year Methods Retrospective survey caregivers patients diagnosed with from 2015 to 2019. The collected data on demographics, diagnosis, income, HMH, private, hospital, government received FCS Bivariate multivariable logistic regressions were used analyze...
Venetoclax is frequently used as salvage treatment in pediatric, adolescent, and young adult (AYA) patients with advanced hematologic malignancies. However, more data are needed from real-world studies to guide the safe appropriate use of venetoclax this population.
Little is known about the risk of post-COVID-19 multisystem inflammatory syndrome in children (MIS-C) setting childhood cancer.