A5082997898- Point processes and geometric inequalities
- Inflammatory Bowel Disease
- Intestinal Malrotation and Obstruction Disorders
- Microscopic Colitis
- Congenital Anomalies and Fetal Surgery
- Congenital gastrointestinal and neural anomalies
- Gastrointestinal disorders and treatments
- Clinical Nutrition and Gastroenterology
- Cardiac, Anesthesia and Surgical Outcomes
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Morphological variations and asymmetry
- Diffusion and Search Dynamics
- Neurofibromatosis and Schwannoma Cases
- Neuroscience and Neural Engineering
- Eosinophilic Esophagitis
- Pain Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Cardiac Arrest and Resuscitation
- Nutrition and Health in Aging
- Aortic aneurysm repair treatments
- Congenital Diaphragmatic Hernia Studies
- IL-33, ST2, and ILC Pathways
- Advanced Fluorescence Microscopy Techniques
- Pediatric Hepatobiliary Diseases and Treatments
Starship Children's Health
2013-2025
Ipsen (United Kingdom)
2025
Ipsen (France)
2024
Ashford and St Peter's Hospitals NHS Foundation Trust
2023
Stanford University
2021
The University of Texas Health Science Center at San Antonio
2021
London South Bank University
2017
University of Florida
2010
Florida College
2010
Royal Hospital for Sick Children
2009
Background & AimsAnti–tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce formation of anti-drug antibodies. The ability to identify patients at increased risk development antibodies would facilitate selection therapy and use preventative strategies.MethodsWe performed a genome-wide association study variants associated with time in discovery cohort 1240 biologic-naïve Crohn's disease...
BackgroundWe sought to report the effectiveness of infliximab and adalimumab over first 3 years treatment define factors that predict anti-TNF failure strategies prevent or mitigate loss response.MethodsPersonalised Anti-TNF therapy in Crohn's disease (PANTS) is a UK-wide, multicentre, prospective observational cohort study reporting rates anti-TNF-naive patients with active luminal aged 6 older. At end year, sites were invited enrol participants still receiving drug into 2-year...
SUMMARY An efficient method is presented for obtaining, in under 4h, an unbiased estimate of the total number neurons human neocortex, with a coefficient error on ∼ 5%. The novel sampling scheme used this study and was designed so that only small amount neocortical grey matter had to be removed. Hence, majority cerebral all internal left intact further resampling analysis. Each hemisphere subdivided into four major regions, sliced coronally at 7‐mm intervals volume neocortex determined using...
Ultrafine and fine particles are potent adjuvants in antigen-mediated immune responses, cause inflammation susceptible individuals. Following recent findings that microparticles accumulate the phagocytes of intestinal lymphoid aggregates, this study is first investigation whether their reduction diet improves symptoms Crohn's disease.In a double blind study, 20 patients with active corticosteroid-treated ileal or ileo-colonic disease randomly received either low microparticle (trial group; n...
Abstract Background Specific image defined risk factors (IDRF) immediately prior to surgery may be more relevant paediatric oncology surgeons than pre‐neoadjuvant IDRFs at diagnosis. The aim of this study was determine IDRF subtypes that independently predict postoperative complications. Methods We searched the New Zealand Children's Cancer Registry for all cases neuroblastoma treated a single centre between January 2007 and February 2021 determined status on pre‐operative imaging diagnosis...
Previously, abobotulinumtoxinA (aboBoNT-A) injected intraoperatively resulted in effective, but delayed post-surgical analgesia pigs. Here, we explore the efficacy of preemptively administered aboBoNT-A intact animals on pain and associated behaviors following a full-skin-muscle incision retraction surgery lower back. AboBoNT-A (200 U/animal) or saline, distributed across ten points, were around anticipated 15, 5, 1 day before via ID route (part A) 15 days ID, intramuscular (IM) subcutaneous...
Background Malnutrition affects between 25 and 40% of all hospitalized patients, the majority whom receive their main nutritional intake from food provided by hospital catering system. There is currently very little published information concerning impact on patients different methods service. Objective In current study effects two service systems, plated bulk service, nutrient were compared. Methods One‐hundred eight patient meals surveyed, 51 meal 57 services. Patients either a general...
<b>Introduction</b> Postoperative antibiotics complement surgery in managing childhood-complicated appendicitis. However, there is limited evidence to guide clinicians on appropriate duration of therapy. A comparison cohort study was performed determine whether tailoring inpatient intravenous (IV) antibiotic therapy patient response, assessed using a set clinical criteria, leads shortened hospital length stay (LOS) without compromising outcomes. <b>Patients and Methods</b> Over 6-month...
Abstract Background It has been consistently observed that a significant proportion of hospital inpatients are malnourished and many actually develop malnutrition in hospital. The NHS provides over 300 million meals each year at cost £500 million, yet there is relatively little research evaluating how well different catering systems provide for the needs inpatients. Aim aim study was to: (i) evaluate whether new steam meal system (Steamplicity) enables patients theory to meet their energy...
Abstract Background and Aims Anti-tumour necrosis factor [anti-TNF] therapy is widely used for the treatment of inflammatory bowel disease, yet many patients are primary non-responders, failing to respond induction therapy. We aimed identify blood gene expression differences between responders non-responders anti-TNF monoclonal antibodies [infliximab adalimumab], predict response status from clinical data. Methods The Personalised Anti-TNF Therapy in Crohn’s Disease [PANTS] study a UK-wide...
Intussusception is the most common cause of preschool intestinal obstruction. International data suggest that a 4-hour observation with prompt return to oral diet safe, following uncomplicated enema reduction. We aimed investigate rate and timing intussusception recurrence across Aotearoa New Zealand, compared cost routine post-reduction observation. performed national 15-year retrospective, multicenter cohort study all children treated for between 01 Jan 2007 2022 AoNZ. A robust clinical...
SUMMARY An inexpensive and efficient method for estimating mean section thickness based on an estimate of the sectioning depth is presented. This value required estimation particle number using disector.