A5068952758- Neuroblastoma Research and Treatments
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer, Hypoxia, and Metabolism
- Testicular diseases and treatments
- Bone Tumor Diagnosis and Treatments
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Tumors and Oncological Cases
- Childhood Cancer Survivors' Quality of Life
- Renal cell carcinoma treatment
- Lymphoma Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Adrenal and Paraganglionic Tumors
- Genetics, Aging, and Longevity in Model Organisms
- Genetics and Neurodevelopmental Disorders
- Trauma and Emergency Care Studies
- Glioma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Congenital Diaphragmatic Hernia Studies
- Bone Metabolism and Diseases
- Polyomavirus and related diseases
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- Emergency and Acute Care Studies
Children's Hospital of Orange County
2018-2025
Children's Center
2014-2016
University of Southern California
2011-2016
Children's Hospital of Los Angeles
2013-2016
Amherst College
2011
Purpose There is a lack of data regarding pediatric trauma patients with cancer diagnosis. The purpose our study to analyze demographics, ED admissions, procedures, and characteristics pertaining this population. Methods NTDB database was queried from 2007 2022. This collected 1,726,681 admissions ≤18. Of these patients, 397 were identified diagnosis had received chemotherapy within 30 days their admission. Results median age 9 years old vs 12 for non-cancer ( P = 0.14), but longer length...
In the United States, approximately 850-900 children and adolescents each year are diagnosed with soft tissue sarcomas (STS). STS divided into rhabdomyosarcoma (RMS) non-rhabdomyosarcoma (NRSTS). RMS NRSTS risk stratified low-, intermediate-, high-risk categories, 5-year survival rates of 90%, 50%-70%, 20%, respectively. Recent key achievements from Children's Oncology Group (COG) Committee include identification new molecular prognostic factors for RMS, development validation a novel...
ABSTRACT Background Prognostic factors are crucial in tailoring treatments for patients with rhabdomyosarcoma (RMS). The European paediatric Soft tissue sarcoma Study Group (EpSSG) and the Children's Oncology (COG) employ similar prognostic factors, but utilize them differently resulting diverse stratification systems. This diversity may result dissimilar treatment approaches comparable hinder comparison of clinical trial results. Procedure We reclassified 1993 enrolled EpSSG RMS 2005 MTS...
Background Esthesioneuroblastoma (ENB) is a rare cancer of the nasal cavity in children. Radical surgery followed by postoperative radiation considered standard care adults. A similar approach children can lead to significant long-term morbidity. Procedure retrospective multi-institutional review patients less than 21 years age diagnosed with ENB between 1990 and 2014 was performed. Clinical features, treatment, outcome were obtained from medical records. Results Twenty-four identified...
Little is known about the risk of post-COVID-19 multisystem inflammatory syndrome in children (MIS-C) setting childhood cancer.
The potential role of osteoblasts in bone and marrow (BM) metastases neuroblastoma (NBL) remains unclear. In this study, we examined the effect NBL cells on osteoblastic differentiation BM-derived mesenchymal stromal (BMMSC). We show that presence enhanced BMMSC driven by morphogenetic protein (BMP)-4, absence any cell proliferation. Expression profiles toward revealed an increase vascular endothelial growth factor A (Vegfa) expression cells. demonstrated increased BMMSC-derived VEGFA mRNA...
10029 Background: Immune checkpoint inhibitors targeting PDL-1 have shown clinical benefit in adults with cancer. We conducted a first pediatrics, phase 1 trial to assess safety, pharmacokinetics (PK), and pharmacodynamics of durvalumab children solid central nervous system malignancies. Methods: This single center investigator-initiated enrolled eligible patients considered incurable measurable/evaluable disease (exception: osteosarcoma 3 rd remission), no prior exposure adequate organ...
Notch signaling pathways can be regulated through a variety of cellular mechanisms, and genetically compromised systems provide useful platforms from which to search for the responsible modulators. The Caenorhabditis elegans gene aph-1 encodes component γ-secretase, is essential events throughout development. By looking suppressors incompletely penetrant aph-1(zu147) mutation, we identify new gene, sao-1 (suppressor aph-one), that negatively regulates activity in early embryo. novel protein...
Encephalopathy is a common side effect of ifosfamide, occurring in up to 30% patients. Although self-resolving most cases, death secondary severe encephalopathy has been reported. Methylene blue and thiamine have occasionally successful as treatment. We report case an 11-year-old girl with relapsed neuroblastoma who developed grade 4 ifosfamide-induced encephalopathy. She showed no initial response methylene thiamine. remained neurologically impaired continuous veno-venous hemodiafiltration...
Abstract Background The survival of patients with localized embryonal rhabdomyosarcoma (RMS) completely resected at diagnosis is greater than 90%. Most have paratesticular, uterine, or vaginal RMS, limiting specific analyses RMS in other anatomic regions. This international study was conducted to define the outcome for sites primary sites. Methods A total 113 aged 0–18 years were identified who enrolled from January 1995 December 2016 Children's Oncology Group (COG) (64 patients) and...
Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal with widespread distribution throughout the body and unpredictable clinical behavior. Recently, a subset of these has been reported to harbor Transcription Factor E3 (TFE3) gene rearrangement distinct morphologic immunophenotypic features. Although limited, may represent separate entity from conventional PEComas require different treatment approaches. Surgery is main option no clear consensus on systemic therapy. Here, we...
PURPOSE Unlike most childhood cancers, therapy for ALL includes a prolonged maintenance phase during which children typically resume regular activities. Physicians need data regarding the persistent impact of COVID-19 in this population to help guide families after pandemic. METHODS The Pediatric Oncology Case Report (POCC) collects deidentified (sociodemographics, clinical [cancer, course]) on children, adolescents, and young adults with cancer from 104 US pediatric oncology institutions....
Abstract Bone metastasis in patients with neuroblastoma often heralds a poor prognosis despite intensive therapy. We previously reported that cells interact osteoclasts and bone marrow mesenchymal stem (BMSC), the nature of this interaction is both osteolytic pro-tumorigenic. In many cancers, suppression osteoblastogenesis plays part increased osteolysis. However, little known about between osteoblasts within microenvironment. have examined context BMSC differentiation to by morphogenetic...
The survival of patients with localized embryonal rhabdomyosarcoma (RMS) completely resected at diagnosis is above 90%. Most them have paratesticular, uterus, or vaginal RMS, limiting specific analyses on RMS in other anatomic regions. To define the outcome for sites than paratesticular/uterine/vaginal primary sites, we conducted this international study.Methods: We identified 113 patients, aged 0-18 years, enrolled from 1/1995 to 12/2016 Children’s Oncology Group (COG) (64 patients) and...