A5015526001- Ethics and Legal Issues in Pediatric Healthcare
- Childhood Cancer Survivors' Quality of Life
- Ethics in medical practice
- Palliative Care and End-of-Life Issues
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
- Patient Dignity and Privacy
- Genomics and Rare Diseases
- Patient-Provider Communication in Healthcare
- Economic and Financial Impacts of Cancer
- COVID-19 and healthcare impacts
- BRCA gene mutations in cancer
- Biomedical Ethics and Regulation
- Neuroblastoma Research and Treatments
- Innovations in Medical Education
- Acute Lymphoblastic Leukemia research
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Treatments and Mutations
- Diversity and Career in Medicine
- Artificial Intelligence in Healthcare and Education
- Child and Adolescent Health
- Prenatal Screening and Diagnostics
- HER2/EGFR in Cancer Research
- Glioma Diagnosis and Treatment
- LGBTQ Health, Identity, and Policy
Boston Children's Hospital
2016-2025
Dana-Farber Cancer Institute
2016-2025
Harvard University
2016-2025
Dana-Farber/Boston Children's Cancer and Blood Disorders Center
2015-2024
Boston Children's Museum
2016-2024
Center for Practical Bioethics
2017-2024
Cancer Trials Ireland
2024
Children's Cancer Center
2024
Vanderbilt University Medical Center
2022
Palmetto Hematology Oncology
2019-2021
Artificial intelligence (AI) tools are rapidly integrating into cancer care. Understanding stakeholder views on ethical issues associated with the implementation of AI in oncology is critical to optimal deployment.
This report presents the American Society of Clinical Oncology's (ASCO's) evaluation adaptations in care delivery, research operations, and regulatory oversight made response to coronavirus pandemic recommendations for moving forward as recedes. ASCO organized its clinical around five goals ensure lessons learned from COVID-19 experience are used craft a more equitable, accessible, efficient system that protects patient safety, ensures scientific integrity, maintains data quality. The...
Oncologist well-being is critical to initiating and maintaining the physician-patient relationship, yet many oncologists suffer from symptoms of burnout. Burnout has been linked poor physical mental health, as well increased medical errors, patient dissatisfaction, workforce attrition. In this Call Action article, we discuss causes interventions for burnout moral distress in oncology, highlight existing interventions, provide recommendations addressing improving at individual organizational...
Genomic tumor profiling (GTP) plays an important role in the care of many adult cancer patients. Its pediatric oncology is still evolving, with only a subset patients currently expected to receive clinically significant results. Little known about perspectives patients/parents on GTP.We surveyed individuals who previously underwent GTP through iCat (Individualized Cancer Therapy) pilot study molecular children relapsed, refractory, and high-risk solid tumors at four centers. Following return...
CRISPR/Cas9 is a rapidly developing gene editing technology that will soon have many clinical applications. As with other new technologies, somatic raises concerns about equitable access to therapies by historically disenfranchised racial and ethnic minorities. We describe justice related CRISPR/Cas9, including its potential impact on mistreated populations through underrepresentation of minorities in genomic databases the for disparate when they become clinically available. then ongoing...
BACKGROUND The majority of patients desire all available prognostic information, but some physicians hesitate to discuss prognosis. objective the current study was examine outcomes disclosure among parents children with cancer. METHODS authors surveyed 353 newly diagnosed cancer at 2 tertiary centers, and each child's oncologist. Using multivariable logistic regression, assessed associations between parental report elements prognosis discussions oncologist (quality information/communication...
In contrast to clinical biopsies, where tissue is collected inform patient care, research biopsies are performed for scientific purposes potentially enhance understanding of the biologic bases cancer and drug action, thereby improving diagnosis treatment, but they may offer no direct benefit participants have known risks. The widespread use that do not potential directly has come under scrutiny, with critics raising ethical concerns related adequacy participant protections, informed consent,...
Paediatric precision oncology aims to match therapeutic agents driver gene targets. We investigated whether parents and patients regret participation in medicine trials, particularly when their hopes are unfulfilled.Parents adolescent completed questionnaires at trial enrolment (T0) after receiving results (T1). Parents opted-in an interview T1. Bereaved a questionnaire 6-months post-bereavement (T1B). analysed quantitative data with R qualitative thematically NVivo, before integrating all...
2][3] The use of AI in cancer care is rapidly expanding: a May 2022 PubMed search the term cross-referenced with revealed approximately 26,000 citations, more than 60% published past five years.4][5] Relative to other parts medicine, implications oncology are outsized, and some idiosyncratic.Oncology tools apply not one but two genomes (germline somatic); can greatly complicate existing weight bias, discrimination, structural racism care; subtly undermine patient physician autonomy, leading...
Advances in genomic testing have been pivotal moving childhood cancer care forward, with now a standard diagnostic tool for many children, adolescents, and young adults cancer. Beyond oncology, the role of pediatric research clinical is growing, including children developmental differences, cardiac abnormalities, epilepsy. Despite more use their patients, pediatricians limited guidance on how to communicate this complex information or engage parents decisions related precision medicine....
Background Esthesioneuroblastoma (ENB) is a rare cancer of the nasal cavity in children. Radical surgery followed by postoperative radiation considered standard care adults. A similar approach children can lead to significant long-term morbidity. Procedure retrospective multi-institutional review patients less than 21 years age diagnosed with ENB between 1990 and 2014 was performed. Clinical features, treatment, outcome were obtained from medical records. Results Twenty-four identified...
AbstractThere is societal consensus that cancer clinical trial participation unjust because some sociodemographic groups have been systematically underrepresented. Despite this, neither a definition nor an ethical explication for the justice norm of equity has clearly articulated in this setting, leading to confusion over its application and goals. Herein we define as acknowledging circumstances apportioning resource opportunity allocation eliminate disparities outcomes, explore issues...
An anthropocentric scope for clinical medical ethics (CME) has largely separated this area of bioethics from environmental concerns. In article, we first identify and reconcile the ethical issues imposed on CME by climate change including dispersion related causes effects, transdisciplinary transhuman nature change, historic divorce environment. We then establish how several moral theories undergirding modern CME, such as virtue ethics, feminist justice, promote both a flourishing human...
Purpose Increasing use of genomic tumor profiling may blur the line between research and clinical care. We aimed to describe perspectives participants about purpose in pediatric oncology. Methods surveyed 45 (response rate, 85%) a pilot study solid tumors at four academic cancer centers after return sequencing results. defined understanding according one-item (basic) definition (recognition that primary was not improve patient’s treatment) four-item (comprehensive) (primary treatment;...
Oncologists face ethical challenges when patients use potentially harmful complementary and alternative medicine in addition to or instead of conventional treatments for their cancer. For example, a patient may forego effective cancer treatment favor therapies suffer significant harm as result. Similarly, false beliefs about the efficacy complicate process shared decision making treatment. In this vignette, we discuss clinicians’ obligations provide recommendations ethically sound...