A5084422354- Neutropenia and Cancer Infections
- Blood groups and transfusion
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Sarcoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Lipid metabolism and disorders
- Parvovirus B19 Infection Studies
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- RNA modifications and cancer
- Tumors and Oncological Cases
- Neuroblastoma Research and Treatments
- Polyomavirus and related diseases
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Cancer therapeutics and mechanisms
UCSF Benioff Children's Hospital
2022-2025
University of California, San Francisco
2022-2025
ABSTRACT Background Thrombopoietin receptor agonists (TPO‐RAs) have demonstrated efficacy in treating clinically significant thrombocytopenia, including chemotherapy‐induced thrombocytopenia adults. However, data regarding their safety and pediatric, adolescents, young adult (AYA) patients with hematologic malignancies are limited. Methods We retrospectively identified 15 pediatric AYA aged 25 years or younger treated a TPO‐RA at UCSF Benioff Children's Hospitals between 2015 2023. Platelet...
Venetoclax is frequently used as salvage treatment in pediatric, adolescent, and young adult (AYA) patients with advanced hematologic malignancies. However, more data are needed from real-world studies to guide the safe appropriate use of venetoclax this population.
Abstract Background The development of tyrosine kinase inhibitors (TKIs) has significantly improved survival rates among patients with Philadelphia chromosome (Ph+) B cell acute lymphoblastic leukemia (B‐ALL). Ph‐like B‐ALL lack the BCR::ABL1 translocation but share gene expression profiles Ph+ B‐ALL. role TKIs for pre‐ and post‐hematopoietic stem transplantation (HSCT) is not yet clear. Case Here we present five cases pediatric, adolescent, young adult who presented or CML in blast phase...
Abstract Pediatric cancer patients are commonly profiled with gene-panel sequencing tests that yield few actionable results, in part due to the complex genomic alterations define these malignancies. We hypothesized integration of whole-genome (WGS) and RNA (RNAseq), would lead a more comprehensive understanding diseases. Our study is uniquely focused on metastatic relapsed disease, whereas previous studies primary cases. also prioritized longitudinal profiling, including deep sequencing,...
Background: V e netoclax is frequently used as salvage treatment in pediatric, adolescent, and young adult (AYA) patients with advanced hematologic malignancies. However, more robust data are needed from real-world studies to guide the safe appropriate use of venetoclax this population. Procedure: We retrospectively reviewed medical records all diagnosed malignancies less than 30 years age treated outside clinical trials at University California San Francisco (UCSF) Benioff Children’s...