A5077186859- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- CNS Lymphoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Musculoskeletal pain and rehabilitation
- Meningioma and schwannoma management
- Health Systems, Economic Evaluations, Quality of Life
- Ocular Oncology and Treatments
- Biochemical Analysis and Sensing Techniques
- Advanced MRI Techniques and Applications
- Anesthesia and Pain Management
- Lanthanide and Transition Metal Complexes
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Opioid Use Disorder Treatment
- Infrared Thermography in Medicine
- Photodynamic Therapy Research Studies
- Optical Imaging and Spectroscopy Techniques
- Spine and Intervertebral Disc Pathology
- Pain Management and Opioid Use
- Neuroscience and Neuropharmacology Research
- Clinical practice guidelines implementation
Duke Medical Center
2019-2024
Duke University
2021-2024
Duke University Hospital
2024
Tulane University
2000
In Brief Study Design. Retrospective analysis of inpatient and outpatient medical insurance claims data from a database containing >100 million individuals. Objective. The aim this study was to quantify the health care resource utilization (HCRU) nonsurgical treatments in first 2 years after chronic, refractory low back pain (CRLBP) diagnosis. Summary Background Data. Patients with persistent (LBP) despite conventional management who are not candidates for spine surgery considered have CRLBP...
BACKGROUND: The management of intracranial oncological disease remains a significant challenge despite advances in systemic cancer therapy. Laser interstitial thermal therapy (LITT) represents novel treatment for local control brain tumors through photocoagulation with stereotactically implanted laser fiber. Because the use continues to increase within neurosurgery, characterization LITT is necessary improve outcomes. OBJECTIVE: To quantify risk tumor seeding along fiber tract patients...
Abstract Purpose: Laser interstitial thermal therapy (LITT) is an effective minimally invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within tumors and amplify the ablative capacity of LITT. Experimental Design: The impact GNS on LITT coverage was tested in ex vivo models using clinical equipment agarose gel–based phantoms control GNS-infused central “tumors.” In accumulation amplification...
Abstract BACKGROUND Laser interstitial thermal therapy (LITT) has clinical utility in treating radiographically progressive brain metastases (BM) following stereotactic radiosurgery (SRS), while resection been reserved for large, symptomatic lesions the upfront setting. Resection-associated morbidity eloquently-located may hinder definitive management. METHODS Patients receiving or LITT BM associated with primary motor cortex (PMC) from 2015-2023 were retrospectively reviewed....
Abstract BACKGROUND Tumor-related epilepsy is a common sequela of both primary and metastatic brain tumors, as well radiation necrosis (RN). Laser interstitial thermal therapy (LITT) an effective option for lesional cytoreduction but induces transient peritumoral edema that typically resolves within 3 months the procedure. Accordingly, we quantified risk seizure development early post-LITT in patients with tumors or RN diverse histologies. METHODS Patients treated LITT at high-volume center...
Abstract BACKGROUND For brain metastases (BM), resection remains a mainstay for the upfront management of large, symptomatic lesions, while laser interstitial thermal therapy (LITT) has become key treatment radiographically progressive BM following stereotactic radiosurgery (SRS). Compared to LITT, resection-associated morbidity may delay systemic therapies. We evaluated functional outcomes versus LITT primary motor cortex (PMC)-associated metastases. METHODS Patients receiving or associated...
The economic burden of cancer in the United States is substantial, and better understanding it essential informing health care policy innovation. Leptomeningeal carcinomatosis (LC) represents a late complication primary spreading to leptomeninges.The IBM MarketScan Research databases were queried for adults diagnosed with LC from 2001 2015, secondary 4 cancers (breast, lung, gastrointestinal, melanoma). Health resource utilization (HCRU) treatment quantified at baseline (1-year pre-LC...
Abstract Introduction Laser interstitial thermal therapy (LITT) is a minimally-invasive treatment option for radiographically-progressive (RP) brain metastases. This study compares the functional outcomes of LITT vs resection (RS) lesions in or near primary motor cortex (PMC). Methods Retrospective review was performed patients treated PMC by RS. Functional were graded relative to pre-treatment symptoms and categorized as improved, stable, worsened at 30, 90, 180 days post-LITT/RS. Results...
Abstract Laser interstitial thermal therapy (LITT) has become increasingly common, particularly in the treatment of progressive lesions after stereotactic radiosurgery for brain metastases. Previous work illustrated sensitivity to its use near critical structures, including corticospinal white matter tracts. A single-surgeon retrospective study was performed patients who underwent LITT or open resection located primary motor cortex, with functional outcomes graded relative pre-treatment...
Abstract Laser interstitial thermal therapy (LITT) is a minimally-invasive technique for the treatment of intracranial tumors that uses stereotactically-guided laser ablation. Magnetic resonance imaging used to monitor ablation progress by measuring cumulative heat energy exposure in both tumor and surrounding tissue calculate damage thresholds.Previous applications GNS have studied extracranial only utilized externally administered near infrared radiation cannot penetrate cranial...
Abstract Laser interstitial thermal therapy (LITT) is a minimally-invasive technique for the treatment of intracranial tumors that uses stereotactically-guided laser and real-time magnetic resonance imaging (MRI) to monitor ablation progress. Previous applications gold nanostars (GNS) in have studied extracranial only utilized externally administered near infrared radiation cannot penetrate cranial compartment. Herein, we present novel platform employing GNS tumors. We developed non-toxic...
INTRODUCTION: The economic burden of low back pain (LBP) in the US is estimated between $84.1 and $624.8 billion. Some patients with LBP that persists despite conventional medical management are ineligible for spine surgery considered to have non-surgical refractory (NSRBP). We investigated healthcare resource utilization (HCRU) NSRBP. METHODS: IBM MarketScan® Research databases were queried adult a diagnosis LBP, excluding instability (eg, spondylolisthesis) non-mechanical etiologies,...
Abstract INTRODUCTION Leptomeningeal carcinomatosis (LC) represents a late complication of primary cancer spreading to the leptomeninges. METHODS The IBM MarketScan® Research databases were queried for adult patients diagnosed with LC between 2001 and 2015, secondary four solid tumors (breast, lung, gastrointestinal, melanoma). outcome was overall healthcare resource utilization (HCRU) each subgroup, quantified as total cost at baseline (1-year pre-LC diagnosis) 30, 90, 365 days post-LC...
Abstract Laser interstitial thermal therapy (LITT) is a growing minimally-invasive approach for treatment of intracranial tumors. Stereotactic placement the laser catheter within target lesion carries theoretical risk tract seeding, which could lead to disease progression. A retrospective analysis patients treated with LITT biopsy-confirmed tumor from 2016-2020 was conducted characterize post-LITT seeding. Forty-two met inclusion criteria, whom 23 (54.7%) had primary brain tumors and 19...
Abstract Laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality for intracranial tumor and radiation necrosis (RN). A transient increase in edema following LITT typically resolves within three months post-procedure. We sought to characterize the short-term seizure outcomes during this period patients undergoing or RN. retrospective analysis of 86 consecutive treated with from 2015-2019 at single institution was conducted. Data on baseline demographics, details,...
Abstract INTRODUCTION Laser interstitial thermal therapy (LITT) is a minimally-invasive treatment option for radiographically-progressive (RP) brain metastases. This study compares the functional outcomes of LITT vs resection (RS) lesions in or near primary motor cortex (PMC). METHODS Retrospective review was performed patients treated PMC by RS. Functional were graded relative to pre-treatment symptoms and categorized as improved, stable, worsened at 30, 90, 180 days post-LITT/RS. RESULTS...
Abstract INTRODUCTION Stereotactic radiosurgery (SRS) is a highly effective therapy for newly diagnosed brain metastases. Risk factors new-onset seizures after SRS have not been well established. In this study, we aimed to characterize the variables predictive of seizure risk. METHODS Patients treated with metastases were retrospectively reviewed at single institution. Data on baseline demographics, radiation parameters, and clinical courses collected. RESULTS 120 patients without previous...