A5007348475- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Meningioma and schwannoma management
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Cancer Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Protein Degradation and Inhibitors
- Cell Image Analysis Techniques
- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- CRISPR and Genetic Engineering
- Management of metastatic bone disease
- Brain Tumor Detection and Classification
- DNA Repair Mechanisms
- Lung Cancer Diagnosis and Treatment
- 3D Printing in Biomedical Research
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Spine and Intervertebral Disc Pathology
- Cancer Immunotherapy and Biomarkers
Duke University
2016-2025
Duke Medical Center
2016-2025
Duke Cancer Institute
2020-2024
Massachusetts Institute of Technology
2013-2023
Duke University Hospital
2019-2023
Durham VA Medical Center
2021
Allen Institute
2020
Duke University Health System
2017-2019
Beth Israel Deaconess Medical Center
2008-2018
Harvard University
2005-2017
Endophilin 1 is a presynaptically enriched protein which binds the GTPase dynamin and polyphosphoinositide phosphatase synptojanin. Perturbation of endophilin function in cell-free systems living synapse has implicated endocytic vesicle budding (Ringstad, N., H. Gad, P. Low, G. Di Paolo, L. Brodin, O. Shupliakov, De Camilli. 1999. Neuron. 24:143–154; Schmidt, A., M. Wolde, C. Thiele, W. Fest, Kratzin, A.V. Podtelejnikov, Witke, W.B. Huttner, H.D. Soling. Nature. 401:133–141; H., N. Ringstad,...
Effective treatment for glioblastoma (GBM) is limited by the presence of blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized nanoparticle (Tf-NP) that can deliver dual combination Using intravital imaging, show ability Tf-NPs traverse intact BBB in mice as well achieve direct tumor binding two intracranial orthotopic models GBM. Treatment tumor-bearing with loaded temozolomide bromodomain inhibitor JQ1...
BackgroundThe dismal survival of glioblastoma (GBM) patients urgently calls for the development new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy, but preclinical and clinical studies in GBM have shown that heterogeneous expression antigens targeted so far causes tumor escape, highlighting need identification targets. We explored if B7-H3 is a valuable target CAR-T GBM.MethodsWe compared mRNA using TCGA data, validated by immunohistochemistry. then tested...
<h3>Background</h3> Ipilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor and are often treated radiation. Therefore, outcomes following ipilimumab radiation of interest, especially given case reports animal studies suggest combined treatment may generate abscopal responses outside the field. <h3>Findings</h3> We reviewed sixteen consecutive patients who received 1 to 8 courses radiation, a sum...
Abstract A significant proportion of patients with brain metastases experience a seizure event during their disease course, which can impact morbidity and long-term outcomes. host factors elevate the risk for seizures in metastases, including patient factors, metabolic imbalances, tumor burden, treatment modality. While reducing burden via local systemic therapies remains critical component to mitigating events, select may remain at risk. The use prophylactic anti-seizure medications be...
We describe the design and results from BraTS 2023 Intracranial Meningioma Segmentation Challenge. The Challenge differed prior Glioma challenges in that it focused on meningiomas, which are typically benign extra-axial tumors with diverse radiologic anatomical presentation a propensity for multiplicity. Nine participating teams each developed deep-learning automated segmentation models using image data largest multi-institutional systematically expert annotated multilabel multi-sequence...
This cohort study evaluates whether immune-checkpoint inhibition therapy concurrent with radiosurgery is associated risk of symptomatic radionecrosis among US patients brain metastases.
Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity cell survival. Dysregulation these systems can lead conflicts between the machinery, causing DNA damage death. BRD4 allows efficient transcriptional elongation by stimulating phosphorylation RNA polymerase II (RNAPII). We report that bromodomain extra-terminal domain (BET) protein loss function (LOF) causes RNAPII pausing on chromatin affecting cells in S-phase....
To develop a neural ordinary differential equation (ODE) model for visualizing deep network behavior during multi-parametric MRI-based glioma segmentation as method to enhance learning explainability.
A key modality of non-surgical cancer management is DNA damaging therapy that causes double-strand breaks are preferentially toxic to rapidly dividing cells. Double-strand break repair capacity recognized as an important mechanism in drug resistance and therefore a potential target for adjuvant chemotherapy. Additionally, spontaneous environmentally induced DSBs known promote cancer, making DSB evaluation tool epidemiology, clinical the development novel pharmaceuticals. Currently available...
Utilization of stereotactic radiosurgery (SRS) for brain metastases (BM) has increased, prompting reassessment whole radiation therapy (WBRT). A pattern care analysis SRS and WBRT dose-fractionations was performed in patients presenting with BM at the time cancer diagnosis.Adults diagnosis between 2010 to 2015 no prior malignancy were identified National Cancer Database. defined using published thresholds. Short (ShWBRT), standard (StWBRT), extended (ExWBRT) as 4 9, 10 15, >15 fractions....
Functional precision medicine platforms are emerging as promising strategies to improve pre-clinical drug testing and guide clinical decisions. We have developed an organotypic brain slice culture (OBSC)-based platform multi-parametric algorithm that enable rapid engraftment, treatment, analysis of uncultured patient tumor tissue patient-derived cell lines. The has supported engraftment every tested this point: high- low-grade adult pediatric rapidly establishes on OBSCs among endogenous...
Abstract Meningiomas are the most common primary intracranial tumors and can be associated with significant morbidity mortality. Radiologists, neurosurgeons, neuro-oncologists, radiation oncologists rely on brain MRI for diagnosis, treatment planning, longitudinal monitoring. However, automated, objective, quantitative tools non-invasive assessment of meningiomas multi-sequence MR images not available. Here we present BraTS Pre-operative Meningioma Dataset, as largest multi-institutional...