A5091351888- Glioma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Meningioma and schwannoma management
- Cervical and Thoracic Myelopathy
- Brain Tumor Detection and Classification
- Medical Imaging and Analysis
- Spinal Hematomas and Complications
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Ferroptosis and cancer prognosis
- Neurofibromatosis and Schwannoma Cases
- Anesthesia and Pain Management
- Bone Tumor Diagnosis and Treatments
- Pancreatic and Hepatic Oncology Research
- Vasculitis and related conditions
- Scoliosis diagnosis and treatment
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Central Venous Catheters and Hemodialysis
- Clinical practice guidelines implementation
- Cell Image Analysis Techniques
- Spinal Dysraphism and Malformations
Thomas Jefferson University
2020-2025
Thomas Jefferson University Hospital
2019-2024
Children's Hospital of Philadelphia
2022-2024
Neurological Surgery
2019-2023
Jefferson Hospital for Neuroscience
2020-2023
Jefferson University Hospitals
2022
Stony Brook University
2020
Oxford University Press (United Kingdom)
2020
Rutgers, The State University of New Jersey
2017-2019
Johnson University
2017-2019
We describe the design and results from BraTS 2023 Intracranial Meningioma Segmentation Challenge. The Challenge differed prior Glioma challenges in that it focused on meningiomas, which are typically benign extra-axial tumors with diverse radiologic anatomical presentation a propensity for multiplicity. Nine participating teams each developed deep-learning automated segmentation models using image data largest multi-institutional systematically expert annotated multilabel multi-sequence...
Despite advancements in molecular and histopathologic characterization of pediatric low-grade gliomas (pLGGs), there remains significant phenotypic heterogeneity among tumors with similar categorizations. We hypothesized that an unsupervised machine learning approach based on radiomic features may reveal distinct pLGG imaging subtypes.Multi-parametric MR images (T1 pre- post-contrast, T2, T2 FLAIR) from 157 patients pLGGs were collected 881 quantitative extracted tumorous region. Clustering...
OBJECTIVE The clinical behavior of meningiomas is not entirely captured by its designated WHO grade, therefore other factors must be elucidated that portend increased tumor aggressiveness and associated risk recurrence. In this study, the authors identify multiparametric MRI radiomic signatures using Ki-67 as a prognostic marker outcomes independent grade. METHODS A retrospective analysis was conducted all resected between 2012 2018. Preoperative MR images were used for high-throughput...
The authors compared primary lumbar spine fusions with revision by using patient Oswestry Disability Index (ODI) scores to evaluate the impact of North American Spine Society (NASS) evidence-based medicine (EBM) fusion indications on patient-reported outcome measures surgeries.
Multicenter study.The COVID-19 pandemic has obligated physicians to recur additional resources and make drastic changes regarding the standard physician-patient encounter. In last century, there been a substantial improvement in technology, which over years opened door new form of medical practicing known as telemedicine.Healthcare workers from three hospitals involved care for patients united states were invited share their experience using telemedicine deliver clinical patients.Since...
Degenerative lumbar spondylolisthesis (DS) patients are treated with instrumented fusion, following EBM guidelines, and typically have excellent clinical outcomes. However, not all fusion procedures adhere to due a lack of prospective data.This retrospective study compared outcomes DS according guidelines (EBM concordant) fused that did clear literature supported this treatment, the goal being examine value present guide care.A total 125 were considered concordant, while 21 discordant. Pre-...
Meningiomas are the most common primary intracranial tumor in adults and can be associated with significant morbidity mortality. Radiologists, neurosurgeons, neuro-oncologists, radiation oncologists rely on multiparametric MRI (mpMRI) for diagnosis, treatment planning, longitudinal monitoring; yet automated, objective, quantitative tools non-invasive assessment of meningiomas mpMRI lacking. The BraTS meningioma 2023 challenge will provide a community standard benchmark state-of-the-art...
We describe the design and results from BraTS 2023 Intracranial Meningioma Segmentation Challenge. The Challenge differed prior Glioma challenges in that it focused on meningiomas, which are typically benign extra-axial tumors with diverse radiologic anatomical presentation a propensity for multiplicity. Nine participating teams each developed deep-learning automated segmentation models using image data largest multi-institutional systematically expert annotated multilabel multi-sequence...
Dispersal of glioblastoma (GBM) cells leads to recurrence and poor prognosis. Accordingly, molecular pathways involved in dispersal are potential therapeutic targets. The mitogen activated protein kinase/extracellular signal regulated kinase (MAPK/ERK) pathway is commonly dysregulated GBM, targeting this with MEK inhibitors has proven effective controlling tumor growth. Since also regulates ECM remodeling actin organization − processes crucial cell adhesion, substrate attachment, motility –...
INTRODUCTION: Pathomics is an emerging data science technique that may be used to extract intricate, sub-visual histopathologic features using high-throughput digital image analysis. METHODS: Using the Children’s Brain Tumor Network database, pediatric medulloblastoma patients were evaluated for inclusion in study. After tumor segmentation, 49 quantitative pathomic extracted a pathology software package (Qupath). LASSO cox proportional hazard model with stratified 5-fold cross-validation was...
Abstract In this study, we present a comprehensive radiogenomic analysis of pediatric low-grade gliomas (pLGGs), combining treatment-naïve multiparametric MRI and RNA sequencing. We identified three immunological clusters using XCell enrichment scores, highlighting an ‘immune-hot’ group correlating with poorer prognosis, suggesting potential benefits from immunotherapies. A radiomic signature predicting profiles showed balanced accuracies 81.5% 84.4% across discovery replication cohorts,...
Abstract BACKGROUND Pediatric medulloblastoma is an aggressive brain tumor and tailored treatment has the potential to lead better patient outcomes. The WHO 2021 classification of involves integrated diagnosis that incorporates genetically defined characteristics, including molecular subgroups (WNT-activated, SHH-activated TP53 wildtype, TP53-mutant, non-WNT/non-SHH). Clinically acquired radiology (MRI) imaging characteristics could provide a non-invasive, pre-treatment biomarker for such...
Glioblastoma is highly aggressive. Early dispersal of the primary tumor renders localized therapy ineffective. Recurrence always occurs and leads to patient death. Prior studies have shown that can be significantly reduced by Dexamethasone (Dex), a drug currently used control brain related edema. However, due high doses significant side effects, treatment tapered discontinued as soon edema has resolved. analyses inhibitory effects Dex were performed on tissue culture plastic, or polystyrene...
Narrative Review.The increasing cost of healthcare overall and for spine surgery, coupled with the growing burden spine-related disease rising demand have necessitated a shift in practice standards new emphasis on value-based care. Despite multiple attempts to reconcile discrepancy between national recommendations appropriate use patterns employed clinical practice, resources continue be overused-often absence any demonstrable benefit. The following discussion illustrates 10 areas further...
Purpose . To describe a case of peripheral ulcerative keratitis in the setting autoimmune hepatitis and possible overlap syndrome with primary sclerosing cholangitis. Case Report A 48-year-old African American female cholangitis presented tearing, irritation, injection left eye that was determined to be keratitis. The patient treated topical systemic steroids, immunosuppressant drugs (azathioprine mycophenolate mofetil), biologic (rituximab), surgery (conjunctival resection), epithelialized...
OBJECTIVE Posterior cervical decompression and fusion (PCDF) is a commonly performed procedure to address myelopathy. A significant number of these patients require revision surgery for adjacent-segment disease (ASD) or pseudarthrosis. Currently, there no consensus among spine surgeons on the inclusion proximal thoracic instrumentation. This study investigates benefits extension in long-segment fusions potential drawbacks. The authors compare outcomes subaxial degenerative myelopathy with...
Spinal synovial cysts are lesions that most commonly occur in the lumbar region. The need for an instrumented spinal fusion addition to decompression with removal of cyst is unknown.To test hypothesis select patients who underwent would be less likely have subsequent surgery (SS) a 2-year period than treated laminectomy alone.This retrospective cohort study was performed using IBM MarketScan Commercial Claims and Encounters Database. Patients had diagnosis or without were included this...
BACKGROUND Subependymal giant cell astrocytoma (SEGA) is a benign intraventricular tumor classically arising near the Foramen of Monro. SEGAs almost always present as component tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by lesions in multiple organs. OBSERVATIONS A 22-year-old female with no past medical history presented new-onset right-eye pressure, floaters right visual field, and pulsatile tinnitus. Imaging revealed avidly enhancing mass abutting...
Abstract BACKGROUND AND IMPORTANCE Carotid-cavernous fistulas (CCF) are pathological connections between carotid artery branches and the cavernous sinus. They can lead to a variety of symptoms, such as chemosis double vision, or more insidious events, vision loss intracranial hemorrhage. Although these patients often treated by endovascular means, we describe case in which patient's CCF was not able be accessed usual methods required an open surgical approach. CLINICAL PRESENTATION The...