A5101559185- Brain Metastases and Treatment
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Lung Cancer Treatments and Mutations
- Advances in Oncology and Radiotherapy
- Ovarian cancer diagnosis and treatment
- Palliative Care and End-of-Life Issues
- Radiopharmaceutical Chemistry and Applications
- BRCA gene mutations in cancer
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Nicotinic Acetylcholine Receptors Study
- Economic and Financial Impacts of Cancer
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Meningioma and schwannoma management
Boston University
2018-2023
Boston Medical Center
2018-2023
Harvard University
2011-2023
Dana-Farber Brigham Cancer Center
2011-2023
Brigham and Women's Hospital
2022
Dana-Farber Cancer Institute
2022
University School
2021
University Medical Center
2019-2020
Radiation Oncology Associates
2015
Massachusetts General Hospital
2007-2012
<h3>Background</h3> Ipilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor and are often treated radiation. Therefore, outcomes following ipilimumab radiation of interest, especially given case reports animal studies suggest combined treatment may generate abscopal responses outside the field. <h3>Findings</h3> We reviewed sixteen consecutive patients who received 1 to 8 courses radiation, a sum...
The declining 5-year overall survival (OS) of patients with laryngeal cancer has been associated increased nonsurgical management stage III/IV disease. To further assess this hypothesis, the authors evaluated recent OS trends and patterns use between larynx-preserving approaches chemoradiation (CRT) or partial laryngectomy (PL) total (TL) stratified by tumor nodal burden.The National Cancer Data Base was used to identify 8703 (excluding T1 tumors) squamous cell carcinoma treated 2003 2011...
Following successful smoking cessation, smokers with schizophrenia are vulnerable to relapse shortly after treatment discontinuation. Our objective was assess the feasibility and effectiveness of a 12-month prevention intervention in recently abstinent schizophrenia.Adult outpatient received weekly cognitive behavioral therapy groups, bupropion slow release, transdermal nicotine patch, gum or lozenge for three months. Subjects seven-day point prevalence abstinence at month 3 an additional 12...
Brain metastases are common in patients with melanoma, and optimal management is not well defined. As melanoma has traditionally been thought of as "radioresistant," the role whole brain radiation therapy (WBRT) particular unclear. We conducted this retrospective study to identify prognostic factors for treated stereotactic radiosurgery (SRS) investigate additional up-front treatment (WBRT).We reviewed records 147 who received SRS part initial their from January 2000 through June 2010....
Objectives/Hypothesis To analyze the impact of hospital safety‐net burden on survival outcomes for laryngeal squamous cell carcinoma (LSCC) patients. Study Design Retrospective cohort study. Methods From 2004 to 2015, 59,733 LSCC patients treated with curative intent were identified using National Cancer Database. Low (LBH) <25th, medium (MBH) 25th–75th, and high (HBH) >75th hospitals defined by percentage quartiles (%) uninsured/Medicaid‐insured treated. Social clinicopathologic...
The aim of this study was to determine if change in stage after neoadjuvant chemoradiation (CRT) associated with improved survival esophageal cancer using a national database.Using the National Cancer Database, patients non-metastatic, resectable who received CRT and surgery were identified. Comparing clinical pathologic stage, classified as complete response (pCR), downstaged, same-staged, or upstaged. Univariable multivariable Cox regression models used identify factors survival.A total...
Men who have sex with men are living HIV at highest risk for anal cancer. Our objective was to use empirical data develop a comprehensive disease simulation model that reflects the most current understanding of carcinogenesis, which is uniquely positioned evaluate future cancer screening strategies and provide insight on unobservable course disease.North America.The individual-based calibrated leveraging primary from studies, such as longitudinal HIV-positive cohort study [Human...
Objective To determine the optimal sequencing of chemoradiotherapy for locally advanced laryngeal cancer. The hypothesis was that concurrent (CCRT) would be associated with improved overall survival (OS) compared to induction chemotherapy followed by radiotherapy (RT)/surgery (IC). Methods National Cancer Database identified 8,154 patients American Joint Commission on stage III/IV (excluding T1) cancer between 2004 and 2013 treated one established organ preservation techniques: CCRT or IC....
Abstract Purpose To develop a knowledge‐based planning (KBP) model that predicts dosimetric indices and facilitates in CyberKnife intracranial stereotactic radiosurgery/radiotherapy (SRS/SRT). Methods Forty SRS/SRT plans were retrospectively used to build linear KBP which correlated the equivalent radius of PTV (r eq_PTV ) volume receives set prescription dose eq_Vi , where V i = 10% 20% … 120% ). evaluate model’s predictability, fourfold cross‐validation was performed for such as gradient...
Primary extraosseous intracranial Ewing's sarcoma, also known as a peripheral primitive neuroectodermal tumor or "small round blue cell tumor," is an extremely rare entity with limited representation in the literature beyond pediatric population.A 67-year-old male suffering occipital headache, nausea, and gait disturbance was found to have large, avidly contrast-enhancing cerebellopontine angle mass extending into cervical spinal canal associated effect on medulla, cerebellum, fourth...
PURPOSE: On-treatment visits (OTVs) for patients undergoing radiotherapy (RT) should occur every five fractions. Compliance with OTVs was identified as a potential issue in safety-net patient population. This study determined if brightly colored placards given to improved OTV compliance. MATERIALS AND METHODS: A retrospective analysis of all lung cancer receiving RT from October 1, 2015 September 30, 2017 evaluated compliance before (No Placard) and after (Placard) the placard introduced...
e18080 Background: TAX-323/324 showed improved response rate and overall survival (OS) with the addition of docetaxel (T) to induction cisplatin/5-FU (PF) prior radiotherapy (ICRT) for stage III/IV laryngeal cancer. However, concomitant chemoradiation (CCRT) is predominant larynx-preserving (LP) technique based on trials comparing it PF-only ICRT. This study evaluates ICRT vs. CCRT utilization outcomes in United States before after publication TAX-323/324. Methods: We identified 8,992...