A5015537570- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Head and Neck Cancer Studies
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Neuroscience and Neural Engineering
- Cancer, Stress, Anesthesia, and Immune Response
- Endometrial and Cervical Cancer Treatments
- Protein Degradation and Inhibitors
- Neural dynamics and brain function
- Esophageal Cancer Research and Treatment
- Oral health in cancer treatment
- Lung Cancer Research Studies
- Polyomavirus and related diseases
- Ovarian cancer diagnosis and treatment
- Epigenetics and DNA Methylation
- HIV/AIDS drug development and treatment
- Ear and Head Tumors
- Transplantation: Methods and Outcomes
- Uterine Myomas and Treatments
- Cancer-related Molecular Pathways
- Pharmacological Receptor Mechanisms and Effects
Tianjin Metallurgical Vocational Technical College
2025
Boston University
2024
Providence College
2024
Boston Medical Center
2018-2023
Brown University
2023
Rhode Island Hospital
2023
First Affiliated Hospital Zhejiang University
2023
Stanford University
2023
Singapore General Hospital
2023
NYU Langone Health
2018-2022
Development of drug resistance from mutations in the targeted viral proteins leads to continuation production by chronically infected cells, contributing HIV-mediated immune dysfunction. Targeting a host cell protein essential for reproduction, rather than protein, may minimize problem as observed with HIV protease inhibitors. We report here development novel class N1-aryl-propane-1,3-diamine compounds using structure-based approach that selectively inhibit activity bromodomain human...
Introduction: Locally advanced non-small cell lung cancer (NSCLC) is highly resistant to chemoradiotherapy, and many patients experience chronic stress. Studies that suggest stimulation of β-adrenergic receptors (β-AR) promotes tumor invasion therapy resistance. We investigated whether β-AR inhibition with beta-blockers acts as a chemotherapy radiation sensitizer in vitro treated chemoradiation for locally NSCLC. Methods: the effects non-selective beta-blocker propranolol on two human...
HPV infections have become the main culprit of thousands deaths by triggering development cervical cancer (approximately 620,000 female cases in 2019, according to data provided WHO) due oncoproteins E6 and E7 expressed high-risk types (for example 16 & 18). To reduce impact brought, other than physical prevention, three prophylactic vaccines- bivalent vaccine (Ceravix), Gardasil 4 vaccine, newest 9 were developed for available uses. Diagnosis screening processes including both molecular...
Breast cancer subtype, determined by expression of estrogen/progesterone receptor (ER/PR) and human epidermal growth factor (HER)-2, is predictive for prognosis. The importance subtype to locoregional recurrence (LRR) following neoadjuvant chemotherapy (NAC) unknown, particularly after adjuvant radiotherapy (RT).We retrospectively identified 160-breast patients registered at Columbia University Medical Center from 1999 2012 treated with NAC, surgery RT.Patients were grouped status: hormone...
Membrane-anchored adaptor proteins FRS2α/β (also known as SNT-1/2) mediate signaling of fibroblast growth factor receptors (FGFRs) and neurotrophin (TRKs) through their N-terminal phosphotyrosine binding (PTB) domains. The FRS2 PTB domain recognizes tyrosine-phosphorylated TRKs at an NP<i>X</i>pY (where pY is phosphotyrosine) motif, whereas its constitutive association with FGFR involves a receptor juxtamembrane region lacking Tyr Asn residues. Here we show by isothermal titration...
INTRODUCTION: Adenoma detection rate (ADR) is an accepted benchmark for screening colonoscopy. Factors driving ADR and its relationship with sessile serrated lesions (SSLDR) over time remain unclear. We aim to explore patient, physician, procedural influences on SSLDR trends. METHODS: Using a large healthcare system in northern California from January 2010 December 2020, total of 146,818 colonoscopies performed by 33 endoscopists were included. calculated using natural language processing....
Epithelioid glioblastoma is an unusual histologic variant of malignant glioma. The present study investigates both the genomic and transcriptomic determinants that may promote development this tumor.Whole-exome sequencing (WES) whole-transcriptome (WTS) were performed on epithelioid glioblastoma, along with a specific bioinformatic pipeline to generate electronic karyotyping investigate tumor immune microenvironment. Microdissected sections containing typical features morphology analyzed...
The aim of this study was to determine if change in stage after neoadjuvant chemoradiation (CRT) associated with improved survival esophageal cancer using a national database.Using the National Cancer Database, patients non-metastatic, resectable who received CRT and surgery were identified. Comparing clinical pathologic stage, classified as complete response (pCR), downstaged, same-staged, or upstaged. Univariable multivariable Cox regression models used identify factors survival.A total...
Two commonly used whole breast irradiation (WBI) techniques, deep inspiration breath hold (DIBH) and prone positioning, are compared with regard to dosimetry estimated late cardiac morbidity secondary lung cancer mortality using published models. Forty patients left-sided DCIS or who underwent lumpectomy required adjuvant WBI were enrolled on a prospective trial comparing supine DIBH (S-DIBH) free breathing (P-FB) planning. Patients CT simulation in both positions; two plans generated for...
Objectives To investigate the efficacy and safety of lung stereotactic body radiation therapy (SBRT) for non-small cell cancer (NSCLC) including oligorecurrent oligoprogressive disease. Methods Single-institution retrospective analysis 60 NSCLC patients with 62 discrete lesions treated SBRT between 2008 2017. Patients were stratified into three groups, early stage, locally recurrent, Group 1 included stage local disease no prior therapy. 2 recurrent after treatment a primary lesion, group 3...