A5003857089- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Historical Economic and Social Studies
- Chemical Reactions and Isotopes
- Radiopharmaceutical Chemistry and Applications
- Corporate Finance and Governance
- Vascular Malformations Diagnosis and Treatment
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
- Meningioma and schwannoma management
- Microtubule and mitosis dynamics
- Accounting and Organizational Management
- Advanced Proteomics Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Management and Organizational Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer, Hypoxia, and Metabolism
- Global Financial Crisis and Policies
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Research and Treatments
- Optical Imaging and Spectroscopy Techniques
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Mass Spectrometry Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
Brown University
2017-2024
Lifespan
2017-2023
Rhode Island Hospital
2017-2023
Cleveland Clinic
1997-2023
University of Leeds
2009-2023
Providence College
2017-2022
Geisinger Health System
2008-2022
Neurological Surgery
1998-2022
Oxford University Press (United Kingdom)
2020
Geisinger Medical Center
2009-2019
Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric to the tumor.To investigate whether TTFields improves progression-free overall survival of patients glioblastoma, a fatal disease commonly recurs at initial tumor site or in central nervous system.In this randomized, open-label trial, 695 whose was resected biopsied had completed concomitant...
<h3>Importance</h3> Glioblastoma is the most devastating primary malignancy of central nervous system in adults. Most patients die within 1 to 2 years diagnosis. Tumor-treating fields (TTFields) are a locoregionally delivered antimitotic treatment that interferes with cell division and organelle assembly. <h3>Objective</h3> To evaluate efficacy safety TTFields used combination temozolomide maintenance after chemoradiation therapy for glioblastoma. <h3>Design, Setting, Participants</h3> After...
Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard newly diagnosed glioblastoma.After surgery chemoradiotherapy, patients were randomized (2:1) receive temozolomide plus DCVax-L (n = 232) or placebo 99). Following recurrence, all allowed DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); secondary...
Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.This phase 3, prospective, externally controlled nonrandomized trial compared overall (OS) in newly diagnosed (nGBM) recurrent (rGBM) treated DCVax-L plus SOC vs contemporaneous matched external...
OBJECTIVE To demonstrate that the shape of configuration fiducial points is an important factor governing target registration error (TRE) in point-based, rigid registration. METHODS We consider two clinical situations: cranial neurosurgery and pedicle screw placement. For neurosurgery, we apply theoretical results concerning TRE prediction, which have previously derived validated, to three hypothetical marker configurations. illustrate profile expected for each configuration. placement, same...
Abstract Clinical diagnosis and treatment decisions for a subset of primary human brain tumors, gliomas, are based almost exclusively on tissue histology. Approaches glioma can be highly subjective due to the heterogeneity infiltrative nature these tumors depend skill neuropathologist. There is therefore critical need develop more precise, nonsubjective, systematic methods classify gliomas. To this end, mass spectrometric analysis has been applied determine glioma-specific protein patterns....
Abstract Purpose: The purpose of this research was to perform a preliminary assessment protein patterns in primary brain tumors using direct-tissue mass spectrometric technique profile and map biomolecules. Experimental Design: We examined 20 prospectively collected, snap-frozen normal tumor specimens matrix-assisted laser desorption/ionization (MALDI) spectrometry (MS), compared peptide expression nontumor tissues. Results: MS can be used identify human tissue specimens. spectral reliably...
<h3>Importance</h3> Tumor-treating fields (TTFields) therapy improves both progression-free and overall survival in patients with glioblastoma. There is a need to assess the influence of TTFields on patients’ health-related quality life (HRQoL). <h3>Objective</h3> To examine association HRQoL among <h3>Design, Setting, Participants</h3> This secondary analysis EF-14, phase 3 randomized clinical trial, compares temozolomide or alone 695 glioblastoma after completion radiochemotherapy....
Abstract Background Tumor treating fields (TTFields) is a non-invasive, antimitotic therapy. In the EF-14 phase 3 trial in newly diagnosed glioblastoma, TTFields plus temozolomide (TTFields/TMZ) improved progression free (PFS) and overall survival (OS) versus TMZ alone. Previous data indicate ≥ 75% daily compliance improves outcomes. We analyzed from TTFields/TMZ patients study to correlate with PFS OS identify potential lower boundary for clinical Methods Compliance was assessed by usage...
IntroductionTumor Treating Fields (TTFields) are approved for glioblastoma based on improved overall survival (OS) and progression-free (PFS) in the phase 3 EF-14 trial of newly diagnosed glioblastoma. To test hypothesis that increasing TTFields dose at tumor site improves patient outcomes, we performed a simulation-based study investigating association between (OS PFS) patients treated with EF-14.Methods MaterialsEF-14 cases (N = 340) were included. Realistic head models derived from...
Purpose The purpose of this paper is to examine the determinants volume environmental disclosures and their quality, with particular focus on role audit committees (ACs) effects Smith report recommendations for UK Corporate Governance Code. Design/methodology/approach Quantitative large sample analysis FTSE350 companies period 2007-2011. Findings Firms higher quality ACs make disclosures. Larger firms block shareholders have greater disclosures, whilst AC does not increase disclosure volume....
Chitinase 3-like 1 (Chi3l1) is a secreted protein that highly expressed in glioblastoma. Here, we show Chi3l1 alters the state of glioma stem cells (GSC) to support tumor growth. Exposure patient-derived GSCs reduced frequency CD133+SOX2+ and increased CD44+Chi3l1+ cells. bound CD44 induced phosphorylation nuclear translocation β-catenin, Akt, STAT3. Single-cell RNA sequencing velocity following incubation with showed significant changes GSC dynamics driving towards mesenchymal expression...
The applicability of optical spectroscopy for intraoperative detection brain tumors/tumor margins was investigated in a pilot clinical trial consisting 26 tumor patients. results this suggest that tumors and infiltrating (ITM) can be effectively separated from normal tissues vivo using combined autofluorescence diffuse-reflectance spectroscopy. A two-step empirical discrimination algorithm based on diffuse reflectance at 460 625 nm developed. This yields sensitivity specificity 100 76%,...
Migration of human glioma cells (hGCs) within the brain parenchyma makes glioblastoma one most aggressive and lethal tumors. Studies cellular molecular mechanisms underlying hGC migration are hindered by limitations existing models. Here we developed a dorsal root ganglion axon-oligodendrocyte-hGC co-culture to study in real time interaction hGCs with their microenvironment. interact myelinated non-myelinated axons through formation pseudopodia. Isolation pseudopodia-localized polysome-bound...
I examine the incidence of fraud from c.1720 to 2009 and relate it occurrence significant financial scandals. Focusing on UK, US prior Enron, using a detailed dataset events news content, underpinned by examination specific watershed scandals, paper highlights regulatory response scandals implications for accounting reporting. The evidence reveals scandal be historically contingent skewed towards certain sectors, particularly banking finance, facilitated complex group structures...
The objective of this article is to compare the United States and British systems business organisation corporate governance during last 50 years. Of particular interest contrasti...
The identification of neoplastic tissue within normal brain during biopsy and tumor resection remains a problem in the operative management gliomas. A variety nanoparticles are phagocytized by macrophages vivo. This feature may allow optical nanoparticles, such as quantum dots, to colocalize with tumors serve an aid surgical or tumors.Male Fisher rats (Charles River Labs, Wilmington, MA) were implanted intracranially C6 gliosarcoma cell lines establish tumors. Two weeks after implantation...
Adult gliomas have indistinct borders. As the ratio of neoplastic cells to normal becomes lower, ability detect these diminishes. We describe a device designed augment intraoperative identification both solid tumor and infiltrating margins.A novel, intraoperative, optical spectroscopic tool, using white light reflectance 337-nm excitation fluorescence spectroscopy, is described. Discrimination algorithms been developed segregate tissues from glial neuronal elements. The spectroscopy was used...
Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between brain environment tumor cells take place during development cancer at its new location. The rapid expansion molecular biology genetics has advanced our knowledge underlying mechanisms involved, from invasion final colonization organ tissues. Understanding various events occurring each stage should enable targeted drug delivery...