A5030874009- Glioma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Neurofibromatosis and Schwannoma Cases
- Immunotherapy and Immune Responses
- Growth Hormone and Insulin-like Growth Factors
- Sarcoma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Bone Tumor Diagnosis and Treatments
- Advanced Radiotherapy Techniques
- Vascular Malformations Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Neuroblastoma Research and Treatments
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Soft tissue tumor case studies
- Nanoparticle-Based Drug Delivery
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Neuroendocrine Tumor Research Advances
University of Colorado Anschutz Medical Campus
2015-2024
University of Colorado Denver
2015-2024
Color (United States)
2024
University of Colorado Health
2003-2022
University of Colorado Boulder
2014-2022
Oxford University Press (United Kingdom)
2020
University of Colorado System
2020
Neurological Surgery
1993-2019
University of Colorado Hospital
1990-2018
Morgan Adams Foundation
2017
The Glioma Outcomes Project represents a contemporary analysis of the management malignant (Grade III and Grade IV/GBM) gliomas in North America. This observational database was used to evaluate influence resection, as opposed biopsy, on patient outcome measured by length survival. Attempts were made reduce impact selection bias repeating data after omitting patients with major negative prognostic factors.Outcome from 788 accrued multiple sites over 4-year period (1997-2001) analyzed primary...
Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard newly diagnosed glioblastoma.After surgery chemoradiotherapy, patients were randomized (2:1) receive temozolomide plus DCVax-L (n = 232) or placebo 99). Following recurrence, all allowed DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); secondary...
Patients with malignant glioma (grade III or IV) face a poor prognosis, and few evidence-based treatment guidelines are available. There is dearth of prospective data on patterns care for these patients.To provide benchmark to enable comparison individual practice outcomes.The Glioma Outcomes (GO) Project enrolled 788 patients at 52 clinical sites, both academic community practices, between December 1997 July 2000. The enrollment criteria included adult primary grade IV undergoing first...
Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.This phase 3, prospective, externally controlled nonrandomized trial compared overall (OS) in newly diagnosed (nGBM) recurrent (rGBM) treated DCVax-L plus SOC vs contemporaneous matched external...
Object. In many new clinical trials of patients with malignant gliomas surgical intervention is incorporated as an integral part tumor-directed interstitial therapies such gene therapy, biodegradable wafer placement, and immunotherapy. Assessment toxicity a major component evaluating these novel therapeutic interventions, but this must be done in light known complication rates craniotomy for tumor resection. Factors predicting neurological outcome would also helpful patient selection...
Convection-enhanced delivery (CED) is a novel intracerebral drug technique with considerable promise for delivering therapeutic agents throughout the CNS. Despite this promise, Phase III clinical trials employing CED have failed to meet end points. Although may be due inactive or failure rigorously validate targets, authors previously demonstrated that catheter positioning plays major role in distribution using technique. The purpose of present work was retrospectively analyze expected based...
✓ The authors' experience with the intraoperative use of real-time ultrasonography during 21 neurosurgical procedures is reported. These include neoplasm surgery in 18 cases, treatment an arteriovenous malformation one case, and ventricular catheter placement for hydrocephalus two cases. In each tumors were imaged just as well through intact dura on brain surface itself. There no cases which pathology could not easily be identified. portable sterile coverings has proven to extremely useful...
The coexistence of traumatic locked facets the cervical spine and a herniated disc is not well described. authors present series patients with who demonstrated high incidence associated herniation documented on magnetic resonance (MR) imaging. Thirteen either unilateral (four cases) bilateral (nine were analyzed retrospectively. Immediate closed reduction using traction and/or manipulation was attempted in first nine cases treated successful only three; however, procedure abandoned three due...
✓ Primary intraosseous meningioma of the skull is an uncommon lesion often confused preoperatively with a primary bone tumor skull. The case without dural connection or association cranial suture reported that was radiographically diagnosed as Paget's disease and initially treated conservatively. Persistent headache prompted biopsy, yielding benign, heavily ossified, psammomatous meningioma. wide surgical excision acrylic cranioplasty. Subsequent review literature has revealed 35 additional...
Interferon-β (IFN-β) is a pleiotropic cytokine with antitumoral activity. In an effort to improve the therapeutic index of IFN-β by providing local, sustained delivery gliomas, safety and biological activity human (hIFN-β)-expressing adenovirus vector (Ad.hIFN-β) was evaluated in patients malignant glioma stereotactic injection, followed 4–8 days later surgical removal tumor additional injections Ad.hIFN-β into bed. Eleven received cohorts 2 × 1010, 6 or 1011 particles (vp). The most common...
Epithelioid and rhabdoid glioblastomas are rare entities that share some overlapping morphologic features, but remain poorly characterized at the immunohistochemical genetic level. We report 10 examples: 8 epithelioid (E-GBMs) 2 GBMs (R-GBMs). E-GBMs tended to be superficially located, circumscribed, supratentorial tumors composed of monotonous, discohesive sheets small rounded cells mimicked metastatic malignant melanoma. R-GBMs showed tumor with classic features arising as a subpopulation...
Gonadotrope and null cell pituitary tumors cause significant morbidity, often presenting with signs of hypogonadism together visual disturbances due to mass effects. Surgery radiation are the only therapeutic options date. To identify dysregulated genes pathways that may play a role in tumorigenesis and/or progression, molecular profiling was performed on 14 gonadotrope tumors, nine normal human pituitaries obtained at autopsy serving as controls. Bioinformatic analysis identified putative...
This prospective clinical trial was undertaken to assess the rate of tumor recurrence in patients with endocrine-inactive pituitary macroadenomas who underwent gross total surgical resection their tumors and did not receive adjuvant radiotherapy.Between December 1987 July 1994, 45 transsphenoidal surgery. In 38 (84%) these patients, achieved confirmed by postoperative magnetic resonance imaging (n = 37) or computed tomography 1). After receiving counseling from neurosurgeon concerning risks...
PURPOSE A retrospective analysis was performed to evaluate the role of surgery in management patients with solitary and multiple brain metastases. PATIENTS AND METHODS Between 1980 1990, 46 underwent surgical resection metastases at University Colorado Health Sciences Center. All but two received postoperative whole-brain radiotherapy a median total dose 30 Gy (range, 11.4 50.0 Gy). Lung most common (56%) primary site adenocarcinoma (46%) tumor histology. Twenty-eight (61%) had metastases,...
Between August 1986 and October 1987, the Denver Brain Tumor Research Group conducted a clinical trial using autologous human recombinant interleukin-2 (rIL-2)-activated lymphocytes to treat 20 patients with recurrent high-grade gliomas. The involved surgical resection and/or decompression followed by intracavitary implantation of lymphokine-activated killer (LAK) cells stimulated (ASL) along rIL-2 in plasma clot. One month later, were infused through Rickham reservoir attached catheter...
Abstract Between August 1986 and October 1987, the Denver Brain Tumor Research Group conducted a clinical trial using autologous human recombinant interleukin-2 (rIL-2)-activated lymphocytes to treat 20 patients with recurrent high-grade gliomas. The involved surgical resection and/or decompression followed by intracavitary implantation of lymphokine-activated killer (LAK) cells stimulated (ASL) along rIL-2 in plasma clot. One month later, were infused through Rickham reservoir attached...
Unlike primary central nervous system lymphomas (PCNSLs) in patients with AIDS or organ transplants, PCNSLs the elderly are usually not considered to be mediated by Epstein Barr virus (EBV); hence, diagnostic studies for EBV routinely performed. We encountered 4 patients, 65 years older, who developed EBV-associated and had been treated a variety of immunosuppressive drugs different autoimmune/collagen vascular disorders, including autoimmune polyneuropathy (mycophenolate mofetil 5 years),...