A5021838474- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Spinal Hematomas and Complications
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Orthopaedic implants and arthroplasty
- Glioma Diagnosis and Treatment
- Shoulder Injury and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Electrospun Nanofibers in Biomedical Applications
- Infectious Diseases and Tuberculosis
- Veterinary Orthopedics and Neurology
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Pain Management
- Spinal Dysraphism and Malformations
- Clinical practice guidelines implementation
- Pelvic and Acetabular Injuries
- Gout, Hyperuricemia, Uric Acid
- Intracerebral and Subarachnoid Hemorrhage Research
BG Klinikum Bergmannstrost Halle
2016-2025
Orthopaedic Research Group
2024
University of Applied Health Sciences
2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2008
Thomas Jefferson University
2005
Freie Universität Berlin
1995-1996
Franklin University
1996
Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard newly diagnosed glioblastoma.After surgery chemoradiotherapy, patients were randomized (2:1) receive temozolomide plus DCVax-L (n = 232) or placebo 99). Following recurrence, all allowed DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); secondary...
Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.This phase 3, prospective, externally controlled nonrandomized trial compared overall (OS) in newly diagnosed (nGBM) recurrent (rGBM) treated DCVax-L plus SOC vs contemporaneous matched external...
In Brief Study Design. Therapeutic treatment of intervertebral disc repair using cells. Objective. The goal the study was to test hypothesis that a damaged is possible autologous adipose tissue derived stem and regenerative cells (ADRCs). Summary Background Data. Degradation resulting from either acute or chronic repetitive injury leads degeneration. However, if could be repaired in early stages, before onslaught degradation, then degeneration process may slowed down. Methods. Twelve dogs...
Plastics have become omnipresent in healthcare but quantitative data on mass flows are scarce. This study, therefore, performed a material flow analysis of single-use medical plastics and their packaging surgical hospital Germany. We quantified the eight different polymers across six product categories consumables, based evaluation consumption for 2018 2019. A total 619 g consumables were used per patient day, which 86% (531 g/patient/day). Plastic contributed an additional 16 g/patient/day....
Multicenter, prospective observational cohort study. 109 patients with lumbar spine stenosis (LSS) undergoing minimally invasive decompression in 6 different centers (Germany, Italy, USA). The demographic, surgical and clinical data was collected. Patients were examined preoperatively, immediately postoperatively, at 12 months after surgery regard to pain (back legs) functional outcomes (ODI, SF-36, EQ5D). mean age of the 67 ± 11 years, a BMI 31.8 6.6 kg/m². Most (93%) underwent single-level...
Study Design Cross-sectional study. Objectives To assess global practices and preferences in the use of osteobiologics for anterior cervical discectomy fusion (ACDF) identify factors influencing choice specific osteobiologics. Methods An online survey developed by AO Spine was distributed to spine surgeons worldwide. The captured demographic characteristics, osteobiologic related information (i.e., previous training, practice patterns, etc.), ACDF. Descriptive statistics, Chi-square tests,...
Degenerated intervertebral discs (IVDs) were treated with autologous adipose-derived stem cells (ASC) loaded into an injectable collagen scaffold in a sheep model to investigate the implant's therapeutic potential regarding progression of degeneration previously damaged discs. In this study, 18 merino subjected 3-step minimally invasive injury and treatment model, which consisted surgically induced disc degeneration, IVDs ASC-loaded hydrogel 6 weeks post-operatively, assessment influence on...
Guideline.
Spinal arteriovenous shunts affect all age groups from neonates to the elderly in connection with different entities. The authors present 7 illustrative cases of spinal and cord vascular lesions etiology, angioarchitecture, symptoms, risks, prognosis, but similar pathophysiology: AVM, multifocal AVM venous impairment, paraspinal fistulas children, dural AV fistula, an malformation filum terminale. Therapy was consistent demonstrated benefit combined treatment. Specific endovascular...
The study presented evaluated the first clinical use of a new multiparameter catheter measuring intracranial pressure (ICP), partial brain tissue oxygen (ptiO2), and temperature (TBr) (Neurovent PTO). To assess validity measured ptiO2 second probe, which represents current golden standard measurement, was implanted (Licox system).Thirty patients with indicated invasive measurement ICP under intensive care unit conditions were included. Using double lumen bolt, simultaneously Licox Neurovent...
Since 2000/2001, no large-scale prospective studies addressing traumatic brain injury (TBI) epidemiology in Germany have been published. Our aim was to look for a possible shift TBI described other European countries, changes management and identify predictors of 1-year outcome especially patients with mild TBI.Observational cohort study.All suffering from any degree between 1 October 2014 30 September 2015, who arrived one the seven participating BG hospitals within 24 hours after trauma,...