A5006929927- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cerebrospinal fluid and hydrocephalus
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Neuroblastoma Research and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Pluripotent Stem Cells Research
- Cancer Immunotherapy and Biomarkers
- Virus-based gene therapy research
- Craniofacial Disorders and Treatments
- Fetal and Pediatric Neurological Disorders
- Cancer Genomics and Diagnostics
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Brain Metastases and Treatment
- 3D Printing in Biomedical Research
- Mesenchymal stem cell research
- CNS Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Multiple Myeloma Research and Treatments
- Cardiac Arrest and Resuscitation
- Neurogenesis and neuroplasticity mechanisms
- Head and Neck Surgical Oncology
Children's Hospital of Orange County
2011-2024
Queensland Government
2024
Queensland University of Technology
2024
University of California, Irvine Medical Center
2016-2022
St. Joseph's Hospital
2022
Saint Joseph's Hospital
2022
University of California, Irvine
2008-2019
St. Joseph Hospital
2018
UC Irvine Health
2017
Neurological Surgery
2008-2015
Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard newly diagnosed glioblastoma.After surgery chemoradiotherapy, patients were randomized (2:1) receive temozolomide plus DCVax-L (n = 232) or placebo 99). Following recurrence, all allowed DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); secondary...
Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.This phase 3, prospective, externally controlled nonrandomized trial compared overall (OS) in newly diagnosed (nGBM) recurrent (rGBM) treated DCVax-L plus SOC vs contemporaneous matched external...
The US National Cancer Institute (NCI) and the Human Genome Research (NHGRI) created Atlas (TCGA) Project in 2006. TCGA's goal was to sequence genomes of 10,000 tumors identify common genetic changes among different types for developing genetic-based treatments. TCGA offered great potential cancer patients, but reality has little impact on clinical applications. Recent reports place past approach testing a small tumor mass at single time-point crossroads. This crossroads presents us with...
Object. The goal of this study was to determine whether adenoviral vector—mediated expression human wildtype p53 can enhance the radiosensitivity malignant glioma cells that express native wild-type . gene is thought function abnormally in majority gliomas, although it has been demonstrated be mutated only approximately 30%. This led studies which transduction with investigated an attempt slow tumor cell growth. Recent suggest reconstitution render more susceptible radiation-mediated death,...
✓ The history of the treatment for hydrocephalus dates back to Fertile Crescent thousands years ago. Despite three millennia management, significant advances in surgical disease have been infrequent. During 1950s, a milestone occurred at Children's Hospital Philadelphia, with successful development first working shunt valve hydrocephalus. In this historical vignette, based on recent interviews John Holter, D.Sc. (Hon) and Eugene Spitz, M.D., review available literature, authors narrate...
The cancer stem cell (CSC) hypothesis posits that deregulated neural cells (NSCs) form the basis of brain tumors such as glioblastoma multiforme (GBM). GBM, however, usually forms in cerebral white matter while normal NSCs reside subventricular and hippocampal regions. We attempted to characterize CSCs from a rare involving neurogenic ventricular wall. described isolating GBM lateral ventricles characterized these with vitro molecular biomarker profiling, cellular behavior, ex vivo...
Glioblastoma multiforme (GBM) remains an incurable brain tumor. The highly malignant behavior of GBM may, in part, be attributed to its intraclonal genetic and phenotypic diversity (subclonal evolution). Identifying the molecular pathways driving relapse may provide novel, actionable targets for personalized diagnosis, characterization prognosis improvement precision therapy. We screened single-cell transcriptomes, namely RNA-seq data primary relapsed tumors from a patient, define profile...
✓ Short-term stimulation of nonantigen-primed peripheral blood mononuclear leukocytes with interleukin-2 generates a population oncolytic effectors designated “lymphokine-activated killer” (LAK) cells. These LAK cells express potent lytic activity against wide spectrum fresh or cultured autochthonous (patient's own) and allogeneic (unrelated) tumors, yet specifically spare normal tissues. In this study, derived from primitive neuroectodermal tumors the posterior fossa (PNET-PF) were examined...
Recent evidence indicates that p53 suppression increased the efficiency of induced pluripotent stem cell (iPSC) generation. This occurred even with enforced expression as few two canonical transcription factors, Oct4 and Sox2. In this study, primary human keratinocytes were successfully into a stage plasticity by transient inactivation p53, without any factors previously used in iPSC These cells later redifferentiated neural lineages. The gene plastic morphologically indistinguishable from...
OBJECTIVE: To improve the prognosis for primary malignant tumors of central nervous system, new therapeutic strategies are needed. Antisense oligodeoxynucleotides (ODNs) offer potential to block expression specific genes within cells. The proto-oncogene c-myc has long been implicated in control normal cell growth and its deregulation development neoplasia. We therefore reasoned that a strategy using ODNs complementary messenger ribonucleic acid would be potent inhibitor glioma proliferation....
We report the first case of a pediatric patient with glioblastoma (GBM; WHO grade IV astrocytoma) successfully treated tumor treating fields (TTF). The was diagnosed GBM when 13 years age and progressed through surgical resection, radiotherapy chemotherapy. Discrete growth visualized on MRI stable neurological examination monitored for 6 months subsequent disease observed radiographically clinically 7 while adherent to Optune® TTF thereby played role in forestalling recurrent this young...
Central nervous system (CNS) aspergillosis remains a daunting diagnosis. This opportunistic mycosis historically carries mortality rate approaching 100% in immunocompromised patients, with death ensuing within days after the onset of neurological symptoms. From their literature review, authors concluded that children contracting CNS while undergoing systemic chemotherapy for leukemias represent particularly unfortunate prognostic group. Antifungal medications prove ineffective treating...
Brain tumors are now the leading cause of cancer-related deaths in children under age 15. Malignant gliomas are, for all practical purposes, incurable and new therapeutic approaches desperately needed. One emerging strategy is to use tumor tracking capacity inherent many stem cell populations deliver agents brain cancer cells. Current limitations therapy include that cells treated as a single entity lack uniform technology adopted selection clinically relevant sub-populations Specifically,...
In children, cancers are the deadliest of diseases and second only to accidents as leading cause death. The brain malignant gliomas. Approximately two-thirds children can survive less types cancers, however, in ~67% these survivors recurs under current regimes surgery followed by administration high doses toxic drugs exposure radiation. Even more distressing is that fortunate generally left with life-long cognitive disabilities. A new medical approach desperately needed. Stem cells, their...
Rising concerns about the short- and long-term detrimental consequences of administration conventional pharmacopeia are fueling search for alternative, complementary, personalized, comprehensive approaches to human healthcare. Qigong, a form Traditional Chinese Medicine, represents viable alternative approach. Here, we started with practical, philosophical, psychological background Ki (in Japanese) or Qi Chinese) their relationship Qigong theory clinical application. Noting drawbacks current...