A5067467531- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Intracranial Aneurysms: Treatment and Complications
- Advanced Radiotherapy Techniques
- Microtubule and mitosis dynamics
- Facial Nerve Paralysis Treatment and Research
- Head and Neck Surgical Oncology
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Herpesvirus Infections and Treatments
- Neurosurgical Procedures and Complications
- Trigeminal Neuralgia and Treatments
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- Cervical and Thoracic Myelopathy
- Glaucoma and retinal disorders
- Cancer-related Molecular Pathways
- Pituitary Gland Disorders and Treatments
- Cancer-related molecular mechanisms research
- Spinal Fractures and Fixation Techniques
Tufts Medical Center
2014-2024
Tufts University
2012-2024
Neurological Surgery
2011-2024
The University of Sydney
2024
Moore College
2024
Boston University
1994-2023
University Medical Center
2023
Baystate Medical Center
1997-2021
Sichuan Cancer Hospital
2021
Beaumont Health
2021
✓ A classification is proposed that unifies and organizes spinal cranial dural arteriovenous fistulous malformations (AVFMs) into three types based upon their anatomical similarities. Type I AVFMs drain directly venous sinuses or meningeal veins. II veins but also have retrograde drainage subarachnoid III do not sinus drainage. The arterial supply in each of these derived from arteries. basis the presented with several cases illustrate AVFMs. rationale for treatment according to...
Standard therapy for glioblastoma includes surgery, radiotherapy, and temozolomide. This Phase 3 trial evaluates the addition of an autologous tumor lysate-pulsed dendritic cell vaccine (DCVax®-L) to standard newly diagnosed glioblastoma.After surgery chemoradiotherapy, patients were randomized (2:1) receive temozolomide plus DCVax-L (n = 232) or placebo 99). Following recurrence, all allowed DCVax-L, without unblinding. The primary endpoint was progression free survival (PFS); secondary...
Signal transducer and activator of transcription 3 (STAT3) regulates diverse cellular processes, including cell growth, differentiation, apoptosis, is frequently activated during tumorigenesis. Recently, putative glioblastoma stem cells (GBM-SCs) were isolated characterized. These can self-renew indefinitely in culture, are highly tumorigenic, retain the ability to differentiate culture. We have found that treatment GBM-SCs with two chemically distinct small molecule inhibitors STAT3...
Glioblastoma is the most lethal primary brain cancer. Clinical outcomes for glioblastoma remain poor, and new treatments are needed.To investigate whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care (SOC) extends survival among patients with glioblastoma.This phase 3, prospective, externally controlled nonrandomized trial compared overall (OS) in newly diagnosed (nGBM) recurrent (rGBM) treated DCVax-L plus SOC vs contemporaneous matched external...
The objective of the Brain Tumor Cooperative Group NIH Trial 87-01 trial was to investigate effect additional implanted radiation therapy in newly diagnosed patients with pathologically confirmed malignant gliomas.The study involved a randomized comparison surgery, external beam radiotherapy, and carmustine (BCNU) versus therapy, interstitial radiotherapy boost, BCNU gliomas. (125)I chosen as best suited for this effort because it allowed preimplantation planning postimplantation quality...
Cell transplantation is safe in animal models and enhances recovery from stroke rats.We studied the safety feasibility of fetal porcine 5 patients with basal ganglia infarcts stable neurological deficits. To prevent rejection, cells were pretreated an anti-MHC1 antibody no immunosuppressive drugs given to patients.The first 3 had adverse cell, procedure, or imaging-defined effects. The fourth patient temporary worsening motor deficits weeks after transplantation, fifth developed seizures 1...
Abstract The epidermal growth factor receptor (EGFR) gene is commonly amplified and rearranged in glioblastoma multiforme leading to overexpression of wild-type mutant EGFRs. Expression EGFR ligands, such as transforming factor-α (TGF-α) or heparin-binding EGF (HB-EGF), also often increased gliomas resulting an autocrine loop that contributes the autonomy glioma cells. Glioblastoma multiformes express a characteristic (EGFRvIII, de 2-7) does not bind ligand, signals constitutively, more...
BACKGROUND: In July 2009, the Accreditation Council for Graduate Medical Education (ACGME) incorporated postgraduate year 1 (PGY1 intern) level training into all U.S. neurosurgery residency programs. OBJECTIVE: To provide a fundamentals curriculum incoming PGY1 residents in ACGME-accredited programs, including skills, knowledge, and attitudes that promote quality, patient safety, professionalism. METHODS: The Society of Neurological Surgeons organized 6 regional "boot camp" courses 2010...
Dynamic alterations in the unique brain extracellular matrix (ECM) are involved malignant tumors. Yet studies of ECM roles tumor cell behavior have been difficult due to lack access human brain. We present a tunable 3D bioengineered tissue platform by integrating microenvironmental cues native brain-derived ECMs and live imaging systematically evaluate patient-derived responses. Using pediatric ependymoma adult glioblastoma as examples, ECM-containing microenvironment with balance cell-cell...
Brain metastases are an increasingly frequent and serious clinical problem for cancer patients, especially those with advanced melanoma. Given the extensive tropism of neural stem/progenitor cells (NSPCs) pathological areas in central nervous system, we expanded investigations to determine whether NSPCs could also target multiple sites brain a syngeneic experimental melanoma model. Using cytosine deaminase-expressing (CD-NSPCs) systemic 5-fluorocytosine (5-FC) pro-drug administration,...
Gamma Knife surgery (GKS) has been shown to be effective in treating trigeminal neuralgia (TN). Existing studies have demonstrated success rates of 69.1-85% with median follow-up intervals 19-60 months. However, series uniform long-term data for all patients lacking. In the present study authors examined outcomes a TN who underwent single GKS treatment followed by minimum 36 They used clinical scale that simplifies reporting outcome TN.Fifty-three consecutive typical, intractable received...
Abstract BACKGROUND Methotrexate‐based and alkylator‐based chemotherapy regimens are associated with renal bone marrow toxicities, which limit their use in patients central nervous system (CNS) lymphomas. The authors report experience an immunochemotherapy regimen consisting of rituximab temozolomide primary or metastatic CNS lymphoma. METHODS Seven who had received were identified from the database brain tumor clinic at authors' institution: three developed recurrent lymphoma (PCNSL), one...
INTRODUCTION: Arteriovenous malformations (AVMs) may cause intracranial hemorrhaging and are usually identifiable by either non-invasive vascular imaging, such as computed tomography angiography (CTA) or magnetic resonance (MRA), with 2- 3-dimensional angiography. However, some rare micro-AVMs (<1cm) not visible on standard METHODS: We identified all patients undergoing diagnostic for suspected brain AVM. Imaging was reviewed cases were in which a micro-AVM diagnosed exclusively CBCT...
The retrovirus-mediated transfer of the herpes simplex virus-thymidine kinase (HSV-tk) gene into tumor cells renders them sensitive to cytocidal effect antiviral drug ganciclovir. This method has shown promising results as a treatment for experimental brain tumors. These experiments indicate that major mechanism effectiveness HSV-tk retroviral therapy may be bystander tumoricidal effect. was hypothesized explain eradication, given efficacy in vivo less than 100%. We demonstrate, this report,...
Abstract OBJECTIVE The objective of the Brain Tumor Cooperative Group NIH Trial 87-01 trial was to investigate effect additional implanted radiation therapy in newly diagnosed patients with pathologically confirmed malignant gliomas. METHODS study involved a randomized comparison surgery, external beam radiotherapy, and carmustine (BCNU) versus therapy, interstitial radiotherapy boost, BCNU 125I chosen as best suited for this effort because it allowed preimplantation planning...
To reach the upper thoracic vertebrae, a number of extensive approaches have been proposed combining thoracotomy, sternotomy, or clavicle resection with anterior dissection into superior mediastinum. We present simple cervical approach for patients disease limited to one vertebral level, in which midline ventral decompression is goal surgery. Regardless used, caudal extent exposure T3 by great vessels mediastinum, whereas angle cervicothoracic junction dictated manubrium. In approach,...
Mutations in the p53 tumor suppressor gene are most common genetic alterations found diverse types of human cancer, including primary malignant brain tumor, glioblastoma multiforme. To estimate frequency mutations tumors, we screened 120 tumors (59 astrocytic; 61 nonastrocytic) by polymerase chain reaction-single-strand conformation polymorphism technique. Six astrocytic (one anaplastic astrocytoma and five multiforme) were to have putative mutations. Direct sequencing reaction-amplified...
Matrix metalloproteinases (MMPs) are enzymes that promote tumor invasion and angiogenesis by enzymatically remodeling the extracellular matrix. MMP-2 MMP-9 most abundant forms of MMPs in malignant gliomas, while a 130 kDa MMP is thought to be complexed other proteinases. This study determined whether doxycycline can block activity vitro. We also measured levels cerebrospinal fluid (CSF) from patients with recurrent gliomas.To determine activity, we extent doxycyline-mediated inhibition vitro...