A5041756550- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Lower Extremity Biomechanics and Pathologies
- Bone and Joint Diseases
- Musculoskeletal pain and rehabilitation
- Breast Cancer Treatment Studies
- Musculoskeletal synovial abnormalities and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition and Health in Aging
- Glaucoma and retinal disorders
- Primary Care and Health Outcomes
- Advanced Radiotherapy Techniques
- Retinal Diseases and Treatments
- Acute Ischemic Stroke Management
- Liver Disease and Transplantation
- Retinal Imaging and Analysis
- Stroke Rehabilitation and Recovery
- Organ Transplantation Techniques and Outcomes
- Breast Implant and Reconstruction
- Transplantation: Methods and Outcomes
- Muscle metabolism and nutrition
- Renal Transplantation Outcomes and Treatments
Tufts Medical Center
2016-2025
Tufts University
2016-2025
Stryker (United States)
2023-2024
Institute of Clinical Research
2011-2023
University of Oxford
2023
Apple (United States)
2023
Bellevue Hospital Center
2023
Park University
2022
Indiana University – Purdue University Indianapolis
2019-2021
Indiana University School of Medicine
2019-2021
<h3>Importance</h3> Synovitis is common and associated with progression of structural characteristics knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage damage synovitis but might have adverse effects on periarticular bone. <h3>Objective</h3> To determine the intra-articular injection 40 mg triamcinolone acetonide every 3 months loss pain. <h3>Design, Setting, Participants</h3> Two-year, randomized, placebo-controlled, double-blind trial vs saline for symptomatic...
purpose. The measurement reproducibility of the third generation commercial optical coherence tomography, OCT-3 (StratusOCT, software ver. A2, Carl Zeiss Meditec Inc., Dublin, CA) was investigated. nerve fiber layer (NFL) thickness, macula thickness map, and optic head (ONH) parameters in normal eyes were studied. methods. Ten subjects imaged six times (three before three after dilation) per day, series repeated on different days. order scans pupil dilation randomized each 3 days scanning....
<h3>Objectives</h3> To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness measurements and to compare these across time with clinical status automated perimetry. <h3>Methods</h3> Retrospective evaluation of 64 eyes (37 patients) glaucoma suspects or patients participating in a prospective longitudinal study. All participants underwent comprehensive assessment, visual field (VF) testing, OCT every 6 months. Field progression was...
<h3>Importance</h3>Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.<h3>Objective</h3>To determine whether supplementation reduces symptom progression knee OA.<h3>Design, Setting, Patients</h3>A 2-year randomized, placebo-controlled, double-blind, clinical trial involving 146 participants with symptomatic OA (mean age,...
<h3>Abstract</h3> <h3>Objectives</h3> To determine the effectiveness of tai chi interventions compared with aerobic exercise, a current core standard treatment in patients fibromyalgia, and to test whether depends on its dosage or duration. <h3>Design</h3> Prospective, randomized, 52 week, single blind comparative trial. <h3>Setting</h3> Urban tertiary care academic hospital United States between March 2012 September 2016. <h3>Participants</h3> 226 adults fibromyalgia (as defined by American...
The type and severity of chronic liver disease may have different effects on health-related quality life (HRQL). aim our study was to determine whether HRQL in patients with differs by identify which clinical physiological factors affect this impairment.In study, measured a generic (Short Form 36) disease-specific (Chronic Liver Disease Questionnaire) questionnaire. Clinical, demographic, laboratory data were collected at office visits. Patient's scores compared the published norms...
The goals were to determine how frequently primary care clinicians reported suspected physical child abuse, the levels of suspicion associated with reporting, and what factors influenced reporting protective services.In this prospective observational study, 434 collected data on 15003 injury visits, including information about injury, child, family, likelihood that was caused by abuse (5-point scale), whether services. Data 327 indicating some for 1683 injuries analyzed.Clinicians 95 (6%)...
Women experience worse outcomes after stroke compared with men. Prior work has suggested sex-based differences in coagulation and fibrinolysis markers subjects acute stroke. We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on patients ischemic
OBJECTIVES. Primary care clinicians participating in the Child Abuse Reporting Experience Study did not report all suspected physical child abuse to protective services. This evaluation of study data seeks (1) identify factors weighed when deciding whether injuries they might have been caused by abuse; (2) describe clinicians’ management strategies for children with from that were reported; and (3) how explained reporting high-suspicion injuries. METHODS. From 434 pediatric primary who...
In Brief Purpose: The purpose of this study was to report normal macular thickness measurements and assess reproducibility retinal acquired by a time-domain optical coherence tomography (OCT) (Stratus, Carl Zeiss Meditec, Inc., Dublin, CA) three commercially available spectral/Fourier domain OCT instruments (Cirrus HD-OCT, Inc.; RTVue-100, Optovue, Fremont, CA; 3D OCT-1000, Topcon, Paramus, NJ). Methods: Forty randomly selected eyes 40 normal, healthy volunteers were imaged. Subjects scanned...
Few remedies effectively treat long-term pain and disability from knee osteoarthritis. Studies suggest that Tai Chi alleviates symptoms, but no trials have directly compared with standard therapies for To compare physical therapy patients Randomized, 52-week, single-blind comparative effectiveness trial. (ClinicalTrials.gov: NCT01258985). An urban tertiary care academic hospital. 204 participants symptomatic osteoarthritis (mean age, 60 years; 70% women; 53% white). (2 times per week 12...
Abstract Racism and discrimination can have significant implications for health, through complex biopsychosocial interactions. Latino groups, particularly Puerto Ricans, are an understudied population in the United States terms of prevalence its relevance to health. Participants our study were 45‐ 75‐year‐old (N = 1122) Ricans. The measures perceived discrimination, depressive symptomatology (CES‐D), stress (PSS), self‐rated medical conditions, blood pressure, smoking drinking behaviours,...
To determine survival time for dogs with splenic hemangiosarcoma treated splenectomy alone, identify potential prognostic factors, and evaluate the efficacy of adjuvant chemotherapy.Retrospective case series.208 dogs.Medical records were reviewed, long-term follow-up information was obtained, data analyzed statistically.154 surgery 54 chemotherapy. Twenty-eight received conventional chemotherapy, 13 cyclophosphamide-based metronomic both Median alone 1.6 months. Clinical stage only factor...
Abstract Introduction Bone marrow lesion (BML) size may be an important imaging biomarker for osteoarthritis-related clinical trials and reducing BML therapeutic goal. However, data on the interrelationships between size, pain, structural progression are inconsistent rarely examined in same cohort. Therefore, we evaluated cross-sectional longitudinal associations of volume with knee pain joint space narrowing (JSN). Methods A assessment was performed magnetic resonance images collected at...
The psychometric properties of Patient Reported Outcomes Measurement Information System (PROMIS) instruments have been explored in a number general and clinical samples. No study, however, has evaluated the function these measures individuals with symptomatic knee osteoarthritis (KOA). aim this project was to evaluate construct (structural) validity floor/ceiling effects four PROMIS population. We conducted secondary analysis baseline data from randomized trial comparing Tai Chi physical...