A5005854046- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Spinal Dysraphism and Malformations
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Mitochondrial Function and Pathology
- Neurofibromatosis and Schwannoma Cases
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Epigenetics and DNA Methylation
- Pituitary Gland Disorders and Treatments
- Multiple Sclerosis Research Studies
- Bone Tumor Diagnosis and Treatments
- Advanced Glycation End Products research
- Fibroblast Growth Factor Research
- Inflammatory Myopathies and Dermatomyositis
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Herpesvirus Infections and Treatments
- Peripheral Neuropathies and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Cancer-related gene regulation
Brown University
2015-2024
Rhode Island Hospital
2015-2024
Providence College
2004-2023
Missouri Department of Transportation
2006-2022
Neurology, Inc
2021
Maine Medical Center
2013
Lifespan
2010
Seton Hall University
2005
John F. Kennedy Medical Center
2000
Regeneron (United States)
1999
Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to accumulation in Alzheimer disease. Amyloid efflux transport is via endothelial low-density lipoprotein receptor-related protein 1 (LRP-1) and P-glycoprotein (P-gp), whereas Aβ influx receptor for advanced glycation end products. Because age major risk factor developing disease, we measured LRP-1 P-gp expression associated transporter with aging rats. Quantitative microvessel was by immunohistochemistry...
In Alzheimer's disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood-cerebrospinal fluid barrier could provide further insight into epithelial and stromal responses neurodegenerative disease states.Transcriptome-wide Affymetrix microarrays were used determine disease-related human CP. RNA from post-mortem samples of entire lateral ventricular was extracted 6 healthy controls (Ctrl), 7...
The frequent co-occurrence of Alzheimer's disease (AD) pathology in patients with normal pressure hydrocephalus suggests a possible link between ventricular dilation and AD. If enlarging ventricles serve as marker faulty cerebrospinal fluid (CSF) clearance mechanisms, then relationship may be demonstrable increasing volume decreasing levels amyloid-beta peptide (Abeta) CSF preclinical early biomarker data (Abeta, tau, phosphorylated tau) well direct measurements whole brain volumes were...
Aging is the most important single risk factor for developing Alzheimer disease. We measured amyloid-β peptide (Aβ) levels in rat cerebral cortex and hippocampus during normal aging of Brown-Norway/Fischer rats. Amyloid-β accumulation was associated with expression Aβ influx transporter, receptor advanced glycation end-products (RAGEs) at blood-brain barrier. Rats selected ages from 3 to 36 months were analyzed by 1) immunohis-tochemistry amyloid deposition quantitative microvessel surface...
The purpose of this study was to determine whether the preoperative MRI findings enhanced diffusivity, macrocyst content, and internal hemorrhage in pituitary macroadenomas are predictive successful transsphenoidal hypophysectomy.We retrospectively reviewed postoperative sella protocol MR images 28 patients who underwent hypophysectomy for chiasm-compressing macroadenoma. Chiasmatic decompression defined surgical success. Two neuroradiologists differentiated nonsolid (macrocystic...
The content and composition of cerebrospinal fluid (CSF) is determined in large part by the choroid plexus (CP) specifically, a specialized epithelial cell (CPe) layer that responds to, synthesizes, transports peptide hormones into out CSF. Together with ventricular ependymal cells, these CPe relay homeostatic signals throughout central nervous system (CNS) regulate CSF hydrodynamics. One new candidate signal augurin, newly recognized 14 kDa protein encoded esophageal cancer related gene-4...
This paper describes a framework for controlling heterogeneous wireless robotic network consisting of aerial and ground vehicles. By use the term heterogeneous, we imply synergy multiple platforms characterized by different dynamics specialized sensing capabilities. Two main scenarios concerning communications are presented: 1) decentralized connectivity strategy in which mesh mobile routers swarms cluttered environment maintaining communication constraints based on spring-mass virtual...
IGV-001 is a type of cellular immunotherapy currently being investigated for treating glioblastoma (NCT04485949). It uses the patient's tumor to elicit an autologous immune response. The process involves (i) craniotomy maximum safe resection glioblastoma, (ii) ex-vivo treatment with anti-sense oligodeoxynucleotide against insulin-like growth factor 1 receptor followed by irradiation, (iii) placement treated in multiple bio-diffusion chambers, which are implanted into abdominal sheath...
Agrin is a heparan sulfate proteoglycan that widely expressed in neurons and microvascular basal lamina the rodent avian central nervous system. induces differentiation of nerve-muscle synapses, but its function either normal or diseased brains not known. Alzheimer’s disease (AD) characterized by loss changes architecture, formation neurofibrillary tangles senile plaques. Here we have asked whether AD causes distribution biochemical properties agrin. Immunostaining normal, aged human system...
By virtue of its ability to regulate the composition cerebrospinal fluid (CSF), choroid plexus (CP) is ideally suited instigate a rapid response traumatic brain injury (TBI) by producing growth regulatory proteins. For example, Esophageal Cancer Related Gene-4 (Ecrg4) tumor suppressor gene that encodes hormone-like peptide called augurin present in large concentrations CP epithelia (CPe). Because thought senescence, neuroprogenitor cell and differentiation CNS, we evaluated kinetics Ecrg4...
Converging evidence suggests a possible link between thyroid state and Alzheimer's disease (AD), including higher probability of dementia in individuals with TSH levels two-fold risk AD patients hypothyroidism. Thyroid hormones modulate factors associated AD, amyloid precursor protein expression the brain, suggesting role for hormone pathology. The present study is first to directly evaluate brain AD. Triiodothyronine (T(3)) thyroxine (T(4)) were measured radioimmunoassay (RIA) post-mortem...
Paclitaxel poliglumex (PPX), a drug conjugate that links paclitaxel to poly-L-glutamic acid, is potent radiation sensitizer. Prior studies in esophageal cancer have demonstrated PPX (50 mg/m/wk) can be administered with concurrent acceptable toxicity. The primary objective of this study was determine the safety combination temozolomide and for high-grade gliomas. Eligible patients were required WHO grade 3 or 4 Patients received weekly combined standard daily (75 mg/m) 6 weeks concomitant...
Patients with hypermobile Ehlers-Danlos syndrome (hEDS), a heritable connective tissue disorder, present frequently symptoms of tethered cord (TCS) but without low-lying conus. Currently, surgical treatment such cases is controversial. Because disorder affects fibrous structures, we hypothesized that diseased filum terminale (FT) might cause TCS in hEDS, justifying transection for treatment. We investigated FT pathology, biomechanics, clinical presentation, and outcome following excision 78...
The craniocervical junction (CCJ) is anatomically complex and comprises multiple joints that allow for wide head neck movements. thecal sac must adjust to such Accordingly, the not rigidly attached bony spinal canal but instead tethered by fibrous suspension ligaments, including myodural bridges (MDBs). authors hypothesized pathological cord motion due laxity of bands in patients with connective tissue disorders, e.g., hypermobile Ehlers-Danlos syndrome (EDS).
Primitive round- or spindle-cell EWSR1-negative undifferentiated sarcomas harboring CIC-DUX4 gene fusion are the most common form of Ewing-like sarcomas. These tumors primarily occur in peripheral soft tissues, but examples have been described within viscera and brain. As far as we aware, positive primary epidural spinal sarcoma has not reported. Herein, describe a T5–T6 tumor 15-year-old girl which many neoplastic cells had moderate focally abundant cytoplasm, including plasmacytoid...
Meningioma is the most common intracranial neoplasm, yet there no effective therapy for recurrent/refractory meningiomas after surgery and radiation. Prostate-specific membrane antigen (PSMA) an enzyme upregulated on endothelial cells of multiple neoplasms being investigated as a theranostic target. Until now, PSMA has not been studied in meningiomas. We aimed to verify expression meningiomas, detect tumor grade variability, investigate relationship signal with recurrence. analyzed 96...