A5014956350- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Food Allergy and Anaphylaxis Research
- Inflammatory mediators and NSAID effects
- Esophageal and GI Pathology
- Allergic Rhinitis and Sensitization
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood groups and transfusion
- Food Safety and Hygiene
- Gut microbiota and health
- Chronic Disease Management Strategies
- Liver Disease and Transplantation
- Diverticular Disease and Complications
- Platelet Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Oral microbiology and periodontitis research
Sutter Health
2022-2025
Palo Alto Institute
2018-2024
Kaohsiung Medical University
2024
Harvard University
2009-2014
Massachusetts General Hospital
2009-2014
Brigham and Women's Hospital
2011-2012
Dana-Farber Cancer Institute
2011-2012
MGH Institute of Health Professions
2010
Importance A safe and effective treatment for recurrent Clostridioides difficile infection (CDI) is urgently needed. Antibiotics kill toxin-producing bacteria but do not repair the disrupted microbiome, which promotes spore germination recurrence. Objectives To evaluate safety rate of CDI recurrence after administration investigational microbiome therapeutic SER-109 through 24 weeks. Design, Setting, Participants This phase 3, single-arm, open-label trial (ECOSPOR IV) was conducted at 72 US...
Geographical variation in the incidence of Crohn's disease (CD) and ulcerative colitis (UC) according to latitude residence has been reported Europe. However, there are no comparable data USA. The CD UC relation was assessed a geographically diverse population women enrolled two large prospective studies USA.A study undertaken Nurses' Health Study I (NHS) 1976 NHS II 1989. Information on state at time birth, age 15 years 30 collected 1992 1993 II. Reported diagnoses incident or end 2003 were...
Abstract Background: Recent studies have shown an association between non-O blood group and risk of pancreatic cancer. It is unclear whether this observed with other gastrointestinal malignancies, including colorectal cancers. Methods: We examined the relationship ABO incident cancer in two large prospective cohorts. calculated HR using Cox proportional hazard modeling while adjusting for known factors Results: During 996,779 person-years follow-up, we documented 1,025 cases Compared to...
Abstract Background Patients experiencing ≥1 recurrence of CDI are at elevated risk for subsequent recurrences and complications versus those with an initial episode. Treatment selection recurrent (rCDI) is influenced by the number a patient has experienced. Fecal microbiota spores, live-brpk (VOWST™; formerly SER-109, hereafter referred to as VOS Vowst Oral Spores) oral microbiota-based therapeutic prevent rCDI in adults after antibacterial treatment rCDI, thought work enabling rapid...
OBJECTIVES: Periodontal disease has been associated with higher circulating levels of inflammatory markers and conditions chronic inflammation, including vascular disease, diabetes mellitus, cancer. Limited data exist on the relationship between periodontal gastric duodenal ulcer. METHODS: We conducted a prospective cohort study 49,120 men in Health Professionals Follow-up Study, aged 40–75 years at enrollment 1986. Biennially, we assessed tooth loss, other risk factors for validated...
Background and Aims Data regarding the influence of dose duration aspirin use on risk gastrointestinal bleeding are conflicting. Methods We conducted a prospective cohort study 32,989 men enrolled in Health Professionals Follow-up Study (HPFS) 1994 who provided biennial data. estimated relative major requiring hospitalization or blood transfusion. Results During 14 years follow-up, 707 reported an episode over 377,231 person-years. After adjusting for factors, regular (≥2 times/week) had...
Bisphosphonates are used for the treatment of bone metastases and have been associated with a lower risk breast cancer. A recent case-control study showed an inverse association between bisphosphonate use colorectal Data from prospective cohorts lacking.We prospectively examined relationship cancer among 86,277 women enrolled onto Nurses Health Study (NHS). Since 1998, participants returned biennial questionnaires in which they were specifically queried about regular bisphosphonates. We Cox...
Despite advances in cross-sectional imaging and the use of molecular markers, distinguishing between benign malignant cysts remains a clinical challenge.To identify both preoperative cyst characteristics at time EUS that predict malignancy.A retrospective analysis was performed on consecutive patients with pancreatic who underwent endoscopic ultrasound (EUS) surgical resection from May 1996 to December 2007 tertiary centre. Clinical history, characteristics, cytology, tumour markers...
The purpose of our study was to identify the clinical and radiologic factors associated with a positive culture during image-guided hip joint aspiration.We performed retrospective analysis 167 consecutive aspirations for septic arthritis at large tertiary medical center. Chart review on following factors: serum WBC count≥11×10(3)/μL, erythrocyte sedimentation rate (ESR)≥20 mm/h, C-reactive protein (CRP)≥100 mg/L, synovial fluid count, polymorphonuclear (PMN) leukocytes≥90%, fever,...
Abstract Background: Gastric adenocarcinoma (GAC) is often diagnosed at advanced stages and portends a poor prognosis. We hypothesized that electronic health records (EHR) could be leveraged to identify individuals highest risk for GAC from the population seeking routine care. Methods: This was retrospective cohort study, with endpoint of incidence as ascertained through linkage an institutional tumor registry. utilized 2010 2020 data Palo Alto Medical Foundation, large multispecialty...
INTRODUCTION: Adenoma detection rate (ADR) is an accepted benchmark for screening colonoscopy. Factors driving ADR and its relationship with sessile serrated lesions (SSLDR) over time remain unclear. We aim to explore patient, physician, procedural influences on SSLDR trends. METHODS: Using a large healthcare system in northern California from January 2010 December 2020, total of 146,818 colonoscopies performed by 33 endoscopists were included. calculated using natural language processing....
Shrimp allergy is a serious public health problem. Epidemiological studies indicated the main cause of food ingestion shrimp and crab. Consequently, reducing risk crab major research focus. Few have demonstrated effect enzyme hydrolysis on reduction allergens in food. In this study, we used papain, commonly industry, as an ingredient to decrease levels allergen tropomyosin shrimp. 0–50U papain was treat meat, then heated measure tropomyosin, determined change protein secondary structure. The...