A5101910331- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Diabetes Treatment and Management
- Diabetes Management and Research
- Renal Transplantation Outcomes and Treatments
- Chronic Disease Management Strategies
- Acute Kidney Injury Research
- Hemodynamic Monitoring and Therapy
- Central Venous Catheters and Hemodialysis
- Diverticular Disease and Complications
- Blood Pressure and Hypertension Studies
- Gastrointestinal disorders and treatments
- Vascular Procedures and Complications
- Ultrasound in Clinical Applications
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Health and Disease Prevention
- Health Systems, Economic Evaluations, Quality of Life
- Body Composition Measurement Techniques
- Pelvic floor disorders treatments
- Healthcare Systems and Reforms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Liver Disease Diagnosis and Treatment
- Medicinal Plants and Neuroprotection
- Radiation Dose and Imaging
Khoo Teck Puat Hospital
2016-2025
Nanyang Technological University
2022-2025
Johns Hopkins University
2019-2020
Johns Hopkins Medicine
2019-2020
University of Miami
2014
Austin Hospital
2011
Queen Elizabeth Hospital
2005-2009
Harvard University
2009
Harvard University Press
2008
Brigham and Women's Hospital
2008
Abstract Introduction During critical illness, oliguria is often used as a biomarker of acute kidney injury (AKI). However, its relationship with the subsequent development AKI has not been prospectively evaluated. Methods We documented urine output and daily serum creatinine concentration in patients admitted for more than 24 hours seven intensive care units (ICUs) from six countries over period two to four weeks. Oliguria was defined by < 0.5 ml/kg/hr. Data were collected until...
IVERTICULAR DISEASE IS A COMmon and costly digestive disorder in Western countries.2][3] Complications, including diverticulitis diverticular bleeding, occur an estimated 10% to 35% of persons with diverticulosis. 4,5Treatment these complications frequently necessitates hospitalization invasive procedures, surgery.At least $2.4 billion direct health care costs 3400 deaths are attributed disease the United States each year, 6,7 medical economic impact this is likely increase substantially as...
OBJECTIVES: Little is known about the effect of physical activity on diverticular complications. This study prospectively examined associations between and bleeding diverticulitis. METHODS: We studied 47,228 US males in Health Professionals Follow-up Study cohort who were aged 40-75 years free disease, gastrointestinal cancer, inflammatory bowel disease at baseline 1986. Men reporting newly diagnosed biennial follow-up questionnaires sent supplemental outlining details diagnosis treatment....
Summary We proposed that many Intensive Care Unit (ICU) patients would be hypothermic in the early postoperative period and hypothermia associated with increased mortality. retrospectively reviewed admitted to ICU after surgery. recorded lowest temperature first 24 h surgery using tympanic membrane thermometers. defined as < 36 °C, severe 35 °C. studied 5050 consecutive patients: 35% were 6% severely hypothermic. In‐hospital mortality was 5.6% for normothermic patients, 8.9% all (p...
Background. To evaluate the prevalence of chronic kidney disease (CKD) in Chinese HIV-infected population.
A renal vascular coordinator (RVC) is a single point-of-contact allied health professional in the early detection and timely intervention of flow dysfunction. In Khoo Teck Puat Hospital (KTPH), RVC performs access ultrasonography assessment assists reviewing direct referrals about dysfunctional arteriovenous fistula (AVF)/arteriovenous graft (AVG) from community dialysis centres plans for appointments with interventional nephrologists surgeons. We conducted prospective study April 2020 to...
Blood pressure is an important determinant of renal perfusion and acute kidney injury (AKI) common in hospital patients. However, there limited knowledge concerning the incidence relative hypotension prior to its development general wards.We compared blood recordings a cohort consecutive patients with no change function changes according RIFLE classes R, I F for AKI. We assessed over 3-day period before AKI index similar controls. excluded absolute [systolic (SBP) <90 mmHg].Patients were old...
Randomized controlled trials have demonstrated the benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2is) in people with type diabetes mellitus (T2DM) and chronic kidney disease (CKD). However, real-world data on CKD progression development end-stage (ESKD) remains scarce. Our aim was to study renal outcomes diabetic (DKD) using SGLT2is a highly prevalent DKD population.Between 2016 2019 we recruited T2DM patients clinics regional hospital Singapore. Patients prescribed were...
In the present study, we examined association between HbA1c variability and renal disease progression based on estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes mellitus (T2DM) Singapore.Glycemic burden function were retrospectively assessed 1628 2002-2014. Multivariable logistic regression was used to assess relationships (expressed as coefficient of variation [HbA1c-CV] quartiles), intrapersonal mean (HbA1c-IM), eGFR decline, adjusted for baseline...
Abstract Background Fluid assessment is challenging, and fluid overload poses a significant problem among dialysis patients, with pulmonary oedema being the most serious consequence. Our study aims to develop simple objective strategy using lung ultrasound (LUS) artificial intelligence (AI) assess status of patients. Methods This was single-centre 76 hemodialysis peritoneal patients carried out between July 2020 May 2022. The assessed via simplified 8-point LUS method portable handheld...
Glomerular hyperfiltration usually occurs early in development of kidney complications diabetes. To understand as a marker renal disease progression type 2 diabetes mellitus, we aimed to examine association between glomerular (estimated filtration rate ⩾ 120 mL/min/1.73 m2) and rapid decline (annual estimated loss 3 m2).This was prospective cohort comprising 1014 patients with mellitus attending Diabetes Centre regional hospital 2002-2014. A separate cohort, 491 who attended or primary-care...
Cognitive impairment is common in haemodialysis patients and associated with adverse health outcomes. This may be due to cognitive impairments interfering daily functioning self-care, but evidence limited. cross-sectional study aims explore the interrelationships between cognition functional outcomes patients.
The first prospective, randomized trial with paired kidney analysis was conducted to compare the efficacy and safety of tacrolimus cyclosporine-based immunosuppressive therapy in renal transplant recipients. This paper reports long-term follow-up results authors' previously published study, main focus on graft survival function.Chinese patients transplanted our centre between June 1998 2005 their deceased were included. Patients included if both kidneys received by centre, thus allowing a...
Fluctuation of kidney function may signify intra-glomerular microvascular hemodynamic instability. We aim to examine the association long-term serum creatinine and estimated glomerular filtration rate variability with diabetic retinopathy.We included type 2 diabetes mellitus patients who attended Diabetes Centre in 2011-2014 were followed up (median = 3.2 years). Digital colour fundus photographs assessed for retinopathy at follow-up. Diabetic severity was categorized into non-proliferative...
ABSTRACT Aim We aim to examine difference in incremental direct medical costs between non‐progressive and progressive chronic kidney disease (CKD) type 2 diabetes mellitus (T2DM) Singapore. Methods This was a prospective study on 676 patients with T2DM attending centre regional hospital. Annual were extracted from the administrative database. Ordinary least squares regression used estimate contribution of CKD progression annual costs, adjusting for demographics baseline clinical covariates....
To characterize haemoglobin A1c (HbA1c) trajectories and examine their associations with chronic kidney disease (CKD) progression.This was a prospective cohort study on 770 patients type 2 diabetes mellitus (T2DM) attending centre in 2002-2017. Group-based trajectory modelling used to identify HbA1c trajectories. Cox proportional hazards models were association between the CKD progression which defined as deterioration across Kidney Disease: Improving Global Outcomes estimated glomerular...
Background . Acute kidney injury (AKI) is common in hospitalised patients. The relationship between body mass index (BMI) and the risk of having AKI for patients acute hospital setting not known, particularly Asian population. Methods This was a retrospective, single-centre, observational study conducted Singapore, multiethnic All aged ≥21 years from January to December 2013 were recruited. Results A total 12,555 eligible analysis. BMI <18.5 kg/m 2 independently associated with...