A5108031387- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- melanin and skin pigmentation
- Urticaria and Related Conditions
- Spondyloarthritis Studies and Treatments
- Skin Protection and Aging
- Circadian rhythm and melatonin
- Asthma and respiratory diseases
- CAR-T cell therapy research
- Autoimmune Bullous Skin Diseases
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Allergic Rhinitis and Sensitization
- Biochemical Analysis and Sensing Techniques
- Cutaneous Melanoma Detection and Management
- Colorectal Cancer Treatments and Studies
- Photoreceptor and optogenetics research
- Protein Degradation and Inhibitors
- Diagnosis and Treatment of Venous Diseases
- Arsenic contamination and mitigation
- Tryptophan and brain disorders
- Melanoma and MAPK Pathways
- Effects of Vibration on Health
- Herpesvirus Infections and Treatments
Kaohsiung Medical University
2016-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2016-2025
National Taiwan University
2006-2025
South China University of Technology
2024
Tzu Chi Foundation
2024
Kaohsiung Municipal Ta-Tung Hospital
2017-2023
Zhejiang Cancer Hospital
2023
Chinese Academy of Sciences
2023
Institute of Clinical Research
2022
University of California, Davis
2018-2020
A cross-sectional study was conducted among fish-processing workers to evaluate the prevalence of shoulder and upper-limb discomforts assess associated ergonomic risk factors. prestructured interview, a medical check-up, job analyses were performed determine musculoskeletal disorders 207 in eight factories. The results showed girdle pain (30.9%), epicondylitis (14.5%), carpal tunnel syndrome (15.0%) as three most common soft-tissue disorders. odds ratio 1.6 (95% CI 1.1-2.5) who tasks with...
Hidradenitis suppurativa (HS), recognized as a chronic and debilitating skin disease, presents significant challenges in both diagnosis treatment. This review explores the clinical manifestations, genetic landscape, molecular mechanisms underlying HS. The disease’s association with predisposing background, obesity, smoking, occlusion underscores complexity of its etiology. Genetic heterogeneity manifests sporadic, familial, syndromic forms, focus on mutations γ-secretase complex genes,...
Adult-onset atopic dermatitis (AD) has recently been recognized as a distinct disease entity, but its risk factors have not yet clearly defined. Although gestational and perinatal exposure to tobacco smoking may be associated with the development of classic AD, association between active/passive adult-onset AD remains controversial.To determine if smoking, including environmental smoke (ETS), is AD.Tobacco ETS were measured in case-control analysis 83 patients physician-diagnosed 142 age-...
Itch is the cardinal symptom of atopic dermatitis (AD). β-Endorphin, a neuropeptide, increased in both AD skin and sera. Interleukin (IL)-31, an itch-relevant cytokine, activates IL-31 receptors keratinocytes. However, how β-endorphin interact remains elusive.To investigate mechanistic interaction AD.This was prospective cross-sectional study. We recruited adult patients with controls according to Hanifin's criteria. Serum levels were measured by enzyme-linked immunosorbent assay....
Abstract Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening skin disease characterized by relapsing and remitting flares of sterile neutrophilic pustules systemic inflammation. The definition GPP inconsistent globally, with large discrepancies in clinical management. To provide guidance on managing GPP, we conducted systematic literature search for articles published within the last decade PubMed Cochrane Library October 2022 held four consensus meetings 12...
Psoriatic arthritis (PsA) is a common comorbidity in patients with psoriasis (PsO) that leads to significant disease burden. Biologic therapies targeting the interleukin (IL)-23/IL-17 axis have been widely used for PsO, but their comparative effectiveness preventing PsA remains unclear. The study objective was compare occurrence of developing incidental among PsO treated interleukin-23 inhibitors (IL23is) or interleukin-17 (IL17is). A retrospective cohort conducted using real-world data from...
The prevalence of selected psychiatric disorders, such as depression and anxiety, is higher in patients with psoriasis. However, the association between psoriasis schizophrenia less clear. Here, we investigated whether In this cross-sectional study, analyzed 1-million-person cohort enrolled from Taiwan's National Health Insurance Research Database. Psoriasis, schizophrenia, comorbidities were ascertained by International Classification Diseases, 9th revision, Clinical Modification coding....
Transient receptor potential ankyrin 1 (TRPA1), a membrane protein ion channel, is known to mediate itch and pain in skin. The function of TRPA1, however, psoriasiform dermatitis (PsD) uncertain. Herein, we found that expression TRPA1 highly up-regulated human psoriatic lesional To study the role PsD, assessed Psoriasis Severity Index (PSI) scores, transepidermal water loss (TEWL), skin thickness pathology, examined dermal inflammatory infiltrates, Th17-related genes itch-related c57BL/6 as...
The main objective of this study was to investigate aluminum, gallium, indium, arsenic, and antimony exposures on blood urine levels in the optoelectronic workers. One hundred seventy subjects were enrolled cohort study. Whole determined by inductively coupled plasma-mass spectrometry. Blood indium gallium arsenic 103 workers significantly higher than that 67 controls during follow-up period. In regression models, significant risk factors exposure job title, preventive equipment, Quetelet's...
To investigate the effects of vibration on peripheral nerves, rabbits were exposed to 60 cycles/s frequency with 0.35 mm amplitude (acceleration: 51 m/s2) for two hours daily. After 150, 250, 450, and 600 vibration, thin sections saphenous median nerves examined under electron microscope. Vibration was found induce following changes: (1) disruption myelin sheath constriction axon, (2) accumulation vacuoles in nodal gap paranodal region, (3) disorganisation end loops detachment from axolemma,...
Psoriasis is a chronic inflammatory disease that affects the skin, joints, and cardiovascular system. Although potential association of end-stage renal (ESRD) with psoriasis has been demonstrated in patients, for use cyclosporin these patients modulation course ESRD remains doubted. Furthermore, between diseases general unclear. This study aimed to investigate risk psoriatic or without cyclosporin. We performed retrospective cohort using National Health Insurance Database Taiwan from 1996...