A5100356158- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Photoacoustic and Ultrasonic Imaging
- Immunotherapy and Immune Responses
- Plasmonic and Surface Plasmon Research
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Radiopharmaceutical Chemistry and Applications
- Berberine and alkaloids research
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ultrasound Imaging and Elastography
- Traditional Chinese Medicine Analysis
- Image Processing Techniques and Applications
- Radiation Therapy and Dosimetry
- Immune cells in cancer
- Industrial Vision Systems and Defect Detection
- Advanced Vision and Imaging
- Dendrimers and Hyperbranched Polymers
- Molecular Communication and Nanonetworks
- Nanocluster Synthesis and Applications
- 2D Materials and Applications
Duke University
2014-2024
Sun Yat-sen University
2024
Korea Advanced Institute of Science and Technology
2021
Shanghai University of Engineering Science
2021
Applied Photonics (United Kingdom)
2018
Photonics (United States)
2014
Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved treatment efficacy specificity.In this study, we developed a gold nanostar (GNS) probe for multi-modality theranostics including surface-enhanced Raman scattering (SERS) detection, x-ray computed tomography (CT), two-photon luminescence (TPL) imaging, photothermal (PTT).We performed radiolabeling, as well CT optical investigate the GNS...
Surface-enhanced Raman scattering (SERS)-active plasmonic nanomaterials have become a promising agent for molecular imaging and multiplex detection. To produce strong SERS intensity while retaining the nonaggregated state biocompatibility needed bioapplications, we integrated near-infrared (NIR) responsive gold nanostars with resonant dyes (SERRS). The SERRS on was several orders of magnitude greater than signals from nanospheres nonresonant nanostars. For first time, demonstrated...
Metastatic spread is the mechanism in more than 90 percent of cancer deaths and current therapeutic options, such as systemic chemotherapy, are often ineffective. Here we provide a proof principle for novel two-pronged modality referred to Synergistic Immuno Photothermal Nanotherapy (SYMPHONY) having potential safely eradicate both primary tumors distant metastatic foci. Using combination immune-checkpoint inhibition plasmonic gold nanostar (GNS)-mediated photothermal therapy, were able...
A unique quintuple-modality theranostic nanoprobe (QMT) is developed with gold nanostars for surface-enhanced Raman scattering (SERS), magnetic resonance imaging (MRI), computed tomography (CT), two-photon luminescence (TPL) and photothermal therapy (PTT). The synthesized were tagged a SERS reporter linked an MRI contrast agent Gd3+. In vitro experiments demonstrated the QMT to be potential future biomedical applications.
Cancer is among the leading cause of death around world, causing close to 10 million deaths each year. Significant efforts have been devoted developing novel technologies that can detect and treat cancer early effectively reduce recurrences, treatment costs, mortality. Gold nanoparticles (GNP) given particular attention for its use with photo-induced hyperthermia coupled immunotherapy methods provide a new platform highly selective less invasive treatment. Among various GNP platforms, gold...
Surface‐Enhanced Raman Scattering (SERS) spectrometry provides an excellent tool to characterize chemical constituents in Traditional Chinese Medicines (TCMs) without requiring separation and extraction procedures. This study involved the use of SERS analyze two TCMs, namely Coptis chinensis Phellodendron amurense , their main active constituent, berberine. Using silver nanospheres as SERS‐active probes, decoctions raw TCMs counterfeits were analyzed. Density functional theory (DFT) was used...
Abstract In this work, we present an overview of the development and application surface‐enhanced Raman scattering (SERS) plasmonic nanoplatforms developed in our laboratory recent years. We have a wide variety plasmonics‐active substrates nanoparticle‐based sensing platforms including inverse molecular sentinels (iMS) utilizing gold nanostars (AuNS) nanorattle DNA sensors (NR). These been used for applications, such as monitoring genomic biomarkers plants renewable bioenergy research,...
To develop an innovative 211At nanoplatform with high radiolabeling efficiency and low in vivo deastatination for future targeted alpha-particle therapy (TAT) to treat cancer.Star-shaped gold nanoparticles, nanostars (GNS), were used as the platform radiolabeling. Radiolabeling under different reaction conditions was tested. Uptake thyroid stomach after systemic administration evaluate stability of 211At-labeled GNS. A subcutaneous U87MG human glioma xenograft murine model preliminarily...
High‐resolution tracking of stem cells remains a challenging task. An ultra‐bright contrast agent with extended intracellular retention is suitable for in vivo high‐resolution following the implantation. Here, plasmonic‐active nanoplatform was developed mesenchymal stromal (MSCs) mice. The consisted TAT peptide‐functionalized gold nanostars (TAT‐GNS) that emit two‐photon photoluminescence capable MSCs under optical imaging. In vitro experiment showed TAT‐GNS‐labeled retained similar...
Aim: To quantitatively and sensitively investigate the biodistribution of immune cells after systemic administration. Methods: Immune were loaded with plasmonic gold nanostars (GNS) tracking probes. Inductively coupled plasma mass spectrometry (ICP-MS) was used for quantitative measurement two-photon photoluminescence (TPL) high-resolution sensitive optical imaging. Results: GNS nanoparticles successfully into without negative effect on cellular vitality. Liver spleen identified to be major...
Abstract Purpose: Laser interstitial thermal therapy (LITT) is an effective minimally invasive treatment option for intracranial tumors. Our group produced plasmonics-active gold nanostars (GNS) designed to preferentially accumulate within tumors and amplify the ablative capacity of LITT. Experimental Design: The impact GNS on LITT coverage was tested in ex vivo models using clinical equipment agarose gel–based phantoms control GNS-infused central “tumors.” In accumulation amplification...
The rapid development of industry 4.0 has promoted the extensive adoption big data analytics for manufacturing industry. In this domain, virtual metrology is a critical technique that able to reduce cost over large amount practical applications. paper, we propose novel tree-based approach simultaneous feature selection and predictive modeling facilitate efficient metrology. proposed method accurately identifies multiple sets then chooses best candidate minimize error. As demonstrated by...
A cell-embedded transparent tissue-mimicking phantom was developed to study high intensity focused ultrasound (HIFU) induced gene activation in vitro. The constructed by using agarose hydro-gel dispersed with rat mammary carcinoma (Mac) cells that were stably transfected GFP plasmid under the control of hsp70B promoter. Thermally sensitive bovine serum albumin (BSA) proteins also incorporated so both lesion formation and could be quantified simultaneously following HIFU exposure. Both...
Cancer has become one of most significant death reasons and causes approximately 7.9 million human deaths worldwide each year. The challenge to detect cancer at an early stage makes cancer-related biomarkers sensing attract more research interest efforts. Surface-enhanced Raman scattering (SERS) provides a promising method for various (DNA, RNA, protein, et al.) detection due its high sensitivity, specificity capability multiple analytes detection. spectroscopy is non-destructive...
Surface-enhanced Raman scattering (SERS) provides a non-destructive sensing method with high sensitivity and multiplex detection capability since SERS takes advantage of enhancement from surface plasmon resonance unique “fingerprint” spectral signature using spectroscopy. Our group has developed plasmonics-active nanoparticle, gold nanostars, tunable plasmonics in near-infrared (NIR) “tissue optical window” without toxic surfactant. We present their applications for chemical biological as...
Surface-enhanced Raman scattering (SERS) is emerging as an alternative non-invasive detection method in many applications. We recently show the use of SERS nanoprobes to detect tumors vivo mice, well sensors plants for mIRNA. In spite these advancements, translation real-world settings has been limited due issues with observing signal over complex background. For example, it remains challenging observe under sunlight or strong illumination (e.g., operating room), using a conventional setup....
Gold nanostars (GNS) have increasingly seen usage in photothermal treatment of diseases such as cancer. Owing to their flexible synthesis, GNS can be easily tuned absorption wavelengths that bypass the non-target tissue. The particles also coupled with other sensing modalities molecular imaging using surface-enhanced Raman spectroscopy (SERS) and Immunotherapy a synergistic manner. We developed combination for cancer therapy called Synergistic Immuno Photo Nanotherapy (SYMPHONY) effectively...