A5101961023- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Neurological disorders and treatments
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Arrest and Resuscitation
- Cardiomyopathy and Myosin Studies
- Anomaly Detection Techniques and Applications
- Heart rate and cardiovascular health
- Ion channel regulation and function
- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Antimicrobial Resistance in Staphylococcus
- Tissue Engineering and Regenerative Medicine
- ECG Monitoring and Analysis
- Long-Term Effects of COVID-19
- Mechanical Circulatory Support Devices
- Diversity and Career in Medicine
- Infective Endocarditis Diagnosis and Management
University of Chicago
2016-2024
University of Chicago Medical Center
2020
University of Illinois Chicago
2018-2020
Septal activation in patients with left bundle-branch block (LBBB) patterns has not been described previously. We performed detailed intracardiac mapping of septal conduction to assess for the presence and level complete (CCB) His-Purkinje system. Response His bundle pacing was assessed without CCB bundle.Left a linear multielectrode catheter consecutive LBBB pattern referred device implantation (n=38) or substrate (n=47). QRS width, duration, His-ventricular (HV) intervals, were analyzed....
Accurate and expedited identification of scar regions most prone to reentry is needed guide ventricular tachycardia (VT) ablation. We aimed prospectively assess outcomes VT ablation guided primarily by the targeting deceleration zones (DZ) identified propagational analysis activation during sinus rhythm.Patients with scar-related were enrolled in University Chicago Ablation Registry between 2016 2018. Isochronal late maps annotated latest local electrogram deflection created high-density...
The circuit boundaries for reentrant ventricular tachycardia (VT) have been historically conceptualized within a 2-dimensional (2D) construct, with their fixed or functional nature unresolved. This study aimed to examine the correlation between localized lines of conduction block (LOB) evident during baseline rhythm lateral isthmus that 3-dimensionally constrain VT as hyperboloid structure.A total 175 activation maps were correlated isochronal late in 106 patients who underwent catheter...
Background: Fast ventricular tachycardias (VTs) have historically been attributed to shorter path lengths with smaller reentrant circuit dimensions in animal models. The relationship between the of VT and tachycardia cycle length (TCL) has not examined humans. This study aimed analyze determinants rate human comparison conduction velocity (CV) across a wide range both stable unstable VTs delineated by high-resolution mapping. Methods: Fifty-four complete delineation (>90% TCL)...
Importance Current left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved would impact referral decisions device type for resynchronization therapy. Objective To develop a simple new criterion LBBB electrophysiological studies human patients, then to validate this in an independent population. Design, Setting, Participants In diagnostic study, the derivation cohort was from...
Clinical factors associated with development of intravascular lead adherence (ILA) are unreliable predictors. Because vascular injury in the superior vena cava-right atrium during transvenous extraction is more likely to occur segments higher degrees ILA, reliable and accurate assessment ILA warranted. We hypothesized that ultrasound (IVUS) could accurately visualize quantify degree correlates difficulty.Serial imaging leads occurred before using IVUS. areas were classified as high or low...
We sought to determine the effectiveness and safety of hydroxychloroquine–azithromycin (HCQ-AZM) therapy in hospitalized patients with COVID-19. This was a retrospective cohort study 613 (integrated health system involving three hospitals) for RT-PCR-confirmed COVID-19 infection between March 1, 2020 April 25, 2020. Intervention treatment HCQ-AZM severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Outcomes interest were in-hospital all-cause mortality, cardiovascular...
We report a 17-year-old boy with large RYR2 exon 3 deletion who has severe catecholaminergic polymorphic ventricular tachycardia (CPVT) phenotype characterized by refractoriness to both nadolol and flecainide which previously not been reported in this subgroup of CPVT patients. Treatment options patient like ours are therefore limited sympathectomy implantable cardioverter-defibrillator implantation should be considered early the treatment course as was done patient. In contrast other...
Abstract Conventional treatment strategies for catecholaminergic polymorphic ventricular tachycardia (CPVT) include avoidance of strenuous exercise and competitive sports, drugs such as ß‐blockers flecainide and, cervical sympathectomy. An implantable cardioverter‐defibrillator (ICD) has been utilized if the response to these is inadequate; however, ICD use in CPVT patients, addition usual complications, associated with an increased risk life‐threatening electrical storm. Ivabradine a...
Cardiovascular implantable electronic device (CIED) infections are associated with significant morbidity and mortality making the identification of causative organism critical. The vast majority CIED caused by Staphylococcal species. atypical pathogens rare have not been systematically investigated. objective this study is to characterize clinical course, management outcome in patients infection secondary pathogens.Medical records all who underwent system extraction at University Chicago...
Although His bundle pacing (HBP) has been shown to improve left ventricular ejection fraction (LVEF), its impact on mitral regurgitation (MR) remains uncertain.
Background The CanGaroo® Envelope (Aziyo Biologics, Silver Spring, MD) is intended to securely hold a cardiovascular implantable electronic device (CIED) create stable environment when implanted in the body. Data on utilization of this newly available product are limited. Objective In study, our objective was describe specific profiles patients who may benefit from use at time CIED implantation. Methods assessed January 2019 October among series were either undergoing de-novo implantation or...
Tabled 1KEY TEACHING POINTS•Ablation failure with AV nodal reentry is uncommon and a left-sided approach useful for refractory cases.•The anatomic relationship between the right left side of septum dictated by offset tricuspid mitral annulus.•Ventricular ablation may be necessary in rare cases to perform slow pathway modification variant reentry. Open table new tab