A5048870250- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Pharmaceutical studies and practices
- Advanced Drug Delivery Systems
- Antibiotics Pharmacokinetics and Efficacy
- Mechanical Circulatory Support Devices
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Cystic Fibrosis Research Advances
- Anesthesia and Sedative Agents
- Advancements in Transdermal Drug Delivery
- Salivary Gland Disorders and Functions
- Sinusitis and nasal conditions
- Botulinum Toxin and Related Neurological Disorders
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory mediators and NSAID effects
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Olfactory and Sensory Function Studies
- Antimicrobial Resistance in Staphylococcus
- COVID-19 epidemiological studies
- Histone Deacetylase Inhibitors Research
- Ferrocene Chemistry and Applications
- Chemical Synthesis and Analysis
- Cardiac Arrhythmias and Treatments
University of Utah
2015-2025
Roseman University of Health Sciences
2013-2024
Texas A&M Health Science Center
2009-2013
South Dakota State University
2007-2008
Indian Institute of Chemical Technology
2007
Global incidence of superficial fungal infections caused by dermatophytes is high and affects around 40 million people. It the fourth most common cause infection. Clotrimazole, a broad spectrum imidazole antifungal agent widely used to treat infections. Conventional topical formulations clotrimazole are intended effective penetration drugs into stratum corneum. However, drawbacks such as poor dermal bioavailability, penetration, variable drug levels limit efficiency. The present study aims...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pathogen of immense public health concern. Efforts to control the disease have only proven mildly successful, and will likely continue cause excessive fatalities until effective preventative measures (such as vaccine) are developed. To develop management strategies, better understanding SARS-CoV-2 pathogenesis population susceptibility infection needed. this end, mathematical modeling can provide robust in silico tool...
Sotalol, a class III antiarrhythmic agent, is used to maintain sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL). Despite its efficacy, sotalol's use limited by potential cause life-threatening ventricular arrhythmias due QT interval prolongation. Traditionally, sotalol administration required hospitalization monitor these risks. The FDA approval of intravenous (IV) for loading before oral maintenance aims reduce duration facilitating an expedited dose, transitioning...
Objectives: Voriconazole is a triazole antifungal used to treat fungal infections in children with cancer. However, previous research reports by our group1 and others2 have shown that voriconazole pharmacokinetics (PK) highly variable this population, many patients fail achieve therapeutic target levels. Subtherapeutic levels of immunocompromised population can be fatal. This study aims develop pediatric PBPK model incorporates observed interpatient variability as well cytochrome P450 (CYP)...
Aim To prepare and characterise lutein-loaded polylactide-co-glycolide–polyethylene glycol–folate (PLGA-PEG-FOLATE) nanoparticles evaluate enhanced uptake in SK-N-BE(2) cells.Methods Nanoparticles were prepared using O/W emulsion solvent evaporation characterised DLS, SEM, DSC, FTIR in-vitro release. Lutein-uptake cells was determined flow-cytometry, confocal-microscopy HPLC. Control lutein PLGA nanoparticles.Results The size of PLGA-PEG-FOLATE 189.6 ± 18.79 nm 188.0 4.06 nm, respectively....
Upper Gastrointestinal Cancers (UGCs) are a leading cause of cancer‐related deaths worldwide. Paclitaxel (PTX) is frequently used for the treatment UGCs; however, low bioavailability, reduced solubility, and dose‐dependent toxicity impede its therapeutic use. PAMAMG 4.0 ‐NH 2 ‐DHA synthesized by linking amine‐terminated fourth‐generation poly(amidoamine) (PAMAMG ) dendrimers with omega‐3 fatty acid docosahexaenoic (DHA). Next, ‐DHA‐PTX (DHATX) ‐PTX (PAX) conjugates subsequent covalent...
Abstract Sialorrhea or drooling is a common problem in children and adults with neurodevelopmental disorders. It can negatively impact the quality of life due to its physical psychological manifestations. Providers commonly prescribe atropine eye drops for topical administration oral mucosa, as an off‐label treatment manage sialorrhea. However, use be associated medication dosing errors systemic side effects. To address these limitations treatment, we developed mucoadhesive gel formulation...
A knowledge gap exists in infant tetrahydrocannabinol (THC) data to guide breastfeeding recommendations for mothers who use cannabis. In the present study, a paired lactation and physiologically based pharmacokinetic (PBPK) model was developed verified. The verified used simulate one hundred virtual lactating (mean age: 28 years, body weight: 78 kg) smoked 0.32 g of cannabis containing 14.14% THC, either once or multiple times. simulated conditions included one-hour post smoking subsequently...