A5048341814- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Tuberculosis Research and Epidemiology
- Cancer therapeutics and mechanisms
- Mycobacterium research and diagnosis
- Sulfur-Based Synthesis Techniques
- Biochemical and Molecular Research
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Pain Mechanisms and Treatments
- Chemical Synthesis and Analysis
- RNA and protein synthesis mechanisms
- Phenothiazines and Benzothiazines Synthesis and Activities
- Chemical Synthesis and Reactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Receptor Mechanisms and Effects
- Crystallography and molecular interactions
- Synthesis and Catalytic Reactions
- Neuroscience and Neuropharmacology Research
- Glycosylation and Glycoproteins Research
- Catalytic Alkyne Reactions
- Neurological diseases and metabolism
- Infectious Diseases and Tuberculosis
Wayne State University
2018-2023
Indian Institute of Technology Bombay
2018-2021
Birla Institute of Technology and Science, Pilani
2013-2018
Birla Institute of Technology and Science - Hyderabad Campus
2016
Peptides are steadily gaining importance as pharmaceutical targets, and efficient, green methods for their preparation critically needed. A key deficiency in the synthetic toolbox is lack of an industrially viable peptide desulfurization method. Without this tool, powerful native chemical ligation reaction typically used to assemble polypeptides proteins remains out reach industrial drug targets. Current require very large excesses phosphine reagents thiol additives or low-abundance metal...
Studies of<italic>S</italic>-linked glycoconjugates have attracted growing interest because of their enhanced chemical stability and enzymatic resistance over<italic>O</italic>-glycoside counterparts.
Abstract The pantothenate biosynthetic pathway is essential for the persistent growth and virulence of Mycobacterium tuberculosis ( Mtb ) one enzymes in pathway, synthetase (PS, EC: 6.3.2.1), encoded by panC gene, has become an appropriate target new therapeutics to treat tuberculosis. Herein, we report nanomolar thiazolidine inhibitors PS developed a rational inhibitor design approach. compounds were discovered using energy‐based pharmacophore modelling subsequent vitro screening, which...
Phosphines and phosphites are critical tools for non-metal desulfurative methodologies due to the strength of P[double bond, length as m-dash]S bond. An overarching premise in these methods has been that stoichiometric (or excess) P(iii) reagent is required reactivity. Despite decades research, a process catalytic phosphine/phosphite not reported. Here, we report successful merging two thermal radical processes: desulfurization unactivated activated alkyl thiols reduction P(v) = S by...
5-exo, 5-exo Cyclizations of conformationally unbiased propargylic aminyl radicals proceed with excellent yield, chemoselectivity, and diastereoselectivity under tin-free reductive cyclization conditions, regardless the electronic environments intermediate radical stabilization resulting from various olefin substituents. These conditions avoid need for slow addition initiator reductant. By contrast, analogous 6-exo, cyclizations require substituents capable to premature reduction products....
The objective of this study is to synthesize and evaluate 1-(4-chlorophenyl)-4-(4-hydroxy-3-methoxy-5-nitrobenzylidene) pyrazolidine-3,5-dione (CD59) analogues establish structure-activity relationship mechanism action. Thirty reported antitubercular CD59 were prepared by two-step synthetic protocols characterized. compounds evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity RAW 264.7 cells. molecules also three mycobacterial enzymes the Among compounds,...
Synthesis and isolation of highly unstable azirinobenzoxazole benzoxazines in a chemodivergent fashion from aryl azido vinylogous carbonates by simple change transition metal acetate is described. Thermal or rhodium(II) acetate-mediated decomposition these azides gave dihydroazirino benzoxazole. Their nickel(II) acetate-promoted reaction 4-dihydro-2H-benzoxazines, whereas copper(II) led to the corresponding oxidized imine derivatives. Benzaoxazine derivative could be kinetically resolved...
Background and Objective: The objective of present study is to explore multiple effects the compound MG17 relate them achieve better therapeutic potential against neuroinflammation related disorders. We examined whether our acting through regulating neuroinflammatory mediators. Methods: have done some preliminary behavioral studies shortlist derivatives using rodent models peripheral nerve injury in earlier publication now we extended screening test compounds efficacy on other neurological...
In the present manuscript, we report synthesis of new 3 and 5 substituted 2-imino thiazolidine-4-ones by three step synthetic protocols from 3-trifluormethyl aniline or 2-amino heterocycle. The compounds were evaluated for in vitro activities against Mycobacterium tuberculosis (MTB) presence absence efflux pump inhibitor, cytotoxicity RAW 264.7 cells. Among thirty six compounds, 2-imino-3-(5-nitrothiazol-2-yl)-5-(3,4,5-trimethoxybenzylidene)thiazolidin-4-one ( 5g ) was found to be most...
Trimethylsilyl trifluoromethanesulfonate mediated dimerization reaction of vinylogous carbamates carbazoles gave highly fluorescent pyridocarbazoles through a Povarov-type formal [4 + 2] cycloaddition-retro-aza-Michael cascade. The developed strategy was used to access indolo pyridocarbazole and quinolizinocarbazolone in an expeditious manner. Various coupling reactions were successfully performed on synthesized study the effect electronics substitution photophysical properties. Synthesized...