A5022339157- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Chemical Synthesis and Analysis
- Proteoglycans and glycosaminoglycans research
- Biochemical and Molecular Research
- Marine Sponges and Natural Products
- Helicobacter pylori-related gastroenterology studies
- RNA Interference and Gene Delivery
- Adenosine and Purinergic Signaling
- Pancreatic function and diabetes
- Advanced Polymer Synthesis and Characterization
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Synthetic Organic Chemistry Methods
- Organometallic Complex Synthesis and Catalysis
- RNA and protein synthesis mechanisms
- Drug Transport and Resistance Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Peptidase Inhibition and Analysis
- HIV/AIDS drug development and treatment
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Alzheimer's disease research and treatments
- Amino Acid Enzymes and Metabolism
- Phytochemical Studies and Bioactivities
Chongqing Medical University
2023-2025
Wayne State University
2019-2025
Dalian Medical University
2023-2024
Second Affiliated Hospital of Chongqing Medical University
2023-2024
Ocean University of China
2024
University of Florida
2017-2020
Gainesville Obstetrics & Gynecology
2020
Sichuan University
2010-2016
State Key Laboratory of Biotherapy
2013
Alzheimer's disease (AD) is the most common form of dementia, marked by progressive brain degeneration and cognitive decline. A major pathological feature AD accumulation hyperphosphorylated tau (p-tau) in neurofibrillary tangles (NFTs), which leads to neuronal death neurodegeneration. P-tau also induces endoplasmic reticulum (ER) stress activates unfolded protein response, causing inflammation apoptosis. Additionally, p-tau spreads through interactions with heparan sulfate (HS)...
The first total synthesis of a major component marine glycolipid vesparioside B (Scheme 1, R1 = n-C22H45, R2 n-C14H29) has been accomplished through convergent [4 + 3] coupling strategy. Key steps included stereoselective installment set challenging 1,2-cis-glycoside bonds. A 2-quinolinecarbonyl-assisted α-galactosylation and novel β-arabinosylation were developed, respectively, to synthesize the α-galactofuranosidic β-arabinopyranosidic linkages. Furthermore, 4,6-O-benzylidene-controlled...
Studies of<italic>S</italic>-linked glycoconjugates have attracted growing interest because of their enhanced chemical stability and enzymatic resistance over<italic>O</italic>-glycoside counterparts.
PD-1/PD-L1 monoclonal antibodies exhibit promising therapeutic effectiveness in multiple cancers. However, developing a simple and efficient non-antibody treatment strategy using the signaling pathway still remains challenging. In this study, we developed flow cytometry assay to screen bioactive compounds with PD-L1 inhibitory activity. A total of 409 marine natural products were screened, sokotrasterol sulfate (SKS) was found efficiently suppress IFN-γ-induced expression. SKS sensitizes...
A new strategy has been developed for GPI glycan-peptide conjugate synthesis based upon a traceless Staudinger reaction between peptide phosphinothioester and glycan azide. The was first studied optimized with simple peptides glycans, which offered excellent yields of the desired conjugates in both organic aqueous solvents. It then used to successfully synthesize an analogue human CD52 antigen containing whole sequence conserved trimannose motif all anchors.
The total synthesis of batatoside L (1), a resin glycoside possessing cytotoxicity against laryngeal carcinoma cells, has been completed in highly convergent manner. most crucial step this was the efficient construction 18-membered macrolactone framework through Corey−Nicolaou macrolactonization approach.
The first total synthesis of batatin VI, an architecturally novel resin glycoside dimer, has been achieved via a convergent [5 + 3] glycosidic coupling approach. An improved protocol for the construction key 18-membered macrolactone core using Keck macrolactonization method was introduced. However, synthesized compound not identical to natural VI.
Heparanase cleaves polymeric heparan sulfate (HS) molecules into smaller oligosaccharides, allowing for release of angiogenic growth factors promoting tumor development and autoreactive immune cells to reach the insulin-producing β cells. Interaction heparanase with HS chains is regulated by specific substrate sulfation sequences. We have synthesized 11 trisaccharides that are highly tunable in structure pattern, us determine how recognizes selects a favorable cleavage site. Our study shows...
Two myo-inositol derivatives having an Nα,Nε-diacetyl-l-lysine (Ac2Lys) moiety linked to the inositol 1-O-position through a self-cleavable linker and metabolically stable 2-azidoethyl group 3-O- 4-O-positions, respectively, were designed synthesized. The Ac2Lys blocking required for GPI biosynthesis was expected be removable by combination of two enzymes, histone deacetylase (HDAC) cathepsin L (CTSL), abundantly expressed in cancer cells, but not normal transform these into biosynthetically...
Solute carrier (SLC) transport proteins play a crucial role in maintaining cellular nutrient and metabolite homeostasis are implicated various human diseases, making them potential targets for therapeutic interventions. However, the study of SLCs has been limited due to lack suitable tools, particularly cell-based substrate uptake assays, necessary understanding their biological functions drug discovery purposes.