A5050987415- Sulfur-Based Synthesis Techniques
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Synthesis and biological activity
Wayne State University
2023
Peptides are steadily gaining importance as pharmaceutical targets, and efficient, green methods for their preparation critically needed. A key deficiency in the synthetic toolbox is lack of an industrially viable peptide desulfurization method. Without this tool, powerful native chemical ligation reaction typically used to assemble polypeptides proteins remains out reach industrial drug targets. Current require very large excesses phosphine reagents thiol additives or low-abundance metal...
Phosphines and phosphites are critical tools for non-metal desulfurative methodologies due to the strength of P[double bond, length as m-dash]S bond. An overarching premise in these methods has been that stoichiometric (or excess) P(iii) reagent is required reactivity. Despite decades research, a process catalytic phosphine/phosphite not reported. Here, we report successful merging two thermal radical processes: desulfurization unactivated activated alkyl thiols reduction P(v) = S by...