A5062579941- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Essential Oils and Antimicrobial Activity
- Dermatology and Skin Diseases
- Analytical Methods in Pharmaceuticals
- Bee Products Chemical Analysis
- Nail Diseases and Treatments
- Lipid Membrane Structure and Behavior
- Pharmaceutical studies and practices
- Analytical Chemistry and Chromatography
- Phytochemistry Medicinal Plant Applications
- Phytoestrogen effects and research
- Skin Protection and Aging
- Surfactants and Colloidal Systems
- Toxin Mechanisms and Immunotoxins
- RNA Interference and Gene Delivery
- Ginger and Zingiberaceae research
- Protein purification and stability
- Insect Pest Control Strategies
- Contact Dermatitis and Allergies
- Medicinal Plants and Neuroprotection
- Proteins in Food Systems
- Fungal Infections and Studies
- Plant Pathogens and Fungal Diseases
Universidade Federal de Goiás
2015-2024
Ashland (United States)
2022
Weatherford College
2022
Universidade Federal de Sergipe
2022
Ricardo (United Kingdom)
2022
Universidade de Brasília
2016-2022
Universidade Federal do Rio Grande do Norte
2022
Coordenação de Aperfeicoamento de Pessoal de Nível Superior
2016
National Council for Scientific and Technological Development
2016
Fundação de Apoio a Pesquisa do Estado de Goiás
2016
Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate effects process formulation variables on properties via Box-Behnken design. Liquid SMEDDS were developed, carvedilol was used as a class II model drug. Mean size, polydispersity index (PdI) zeta resulting microemulsions...
Abstract Objectives The aim of this study was to investigate in vitro the epidermal targeting potential clobetasol propionate-loaded nanostructured lipid carriers (CP-NLC) when compared that chitosan-coated (CP-NLC-C). Methods CP-NLC were prepared by microemulsion method and characterized dynamic light scattering, transmission electron microscopy, release permeation studies. To verify targeting, studies performed two sets experiments. For first set, skin removed from diffusion cell stratum...
Abstract Clobetasol propionate (CLO) is a potent glucocorticoid used to treat inflammation-based skin, scalp, and hair disorders. In such conditions, follicles (HF) are not only the target site but can also act as drug reservoirs when certain formulations topically applied. Recently, we have demonstrated nanostructured lipid carriers (NLC) containing CLO presenting epidermal-targeting potential. Here, focus was evaluating HF uptake provided by nanoparticles in comparison commercial cream...
The combination of iontophoresis with solid lipid nanoparticles (SLNs) for targeting drug delivery to the epidermis has not been explored. goal this paper was study influence on penetration doxorubicin (DOX) delivered in SLNs (DOX-SLNs). We measured contribution electroosmotic flow transport DOX, and accumulation DOX stratum corneum (SC) viable determined. In addition, we evaluated cytotoxicity DOX-SLNs against skin cancer cells. Iontophoresis unloaded decreased by a factor 5 increased...
To design and evaluate the potential of a topical delivery system for ocular administration voriconazole, based on cationic nanostructured lipid carriers (NLCs).NLC dispersions composed glyceryl behenate/capric caprylic triglyceride, polysorbate 80, sorbitan trioleate, cetylpyridinium chloride were obtained characterized. Ex vivo permeations experiments performed to their drug potential.NLCs presented mean diameter 250.2 ± 03.1 nm, narrow polydispersity index (0.288 0.03), positive zeta...
Topical chemotherapy using doxorubicin, a powerful anticancer drug, can be used as an alternative with reduced systemic toxicity when treating skin cancer. The aim of the present work was to use factorial design-based studies develop cationic solid lipid nanoparticles containing doxorubicin; further investigations into influence these particles on drug's cytotoxicity and cellular uptake in B16F10 murine melanoma cells were performed. A 32 full design applied for two different phases; one...
Clobetasol propionate (CP) is a potent topical corticosteroid that causes several cutaneous and systemic side effects. In the present work, CP was encapsulated in nanostructured lipid carriers (NLCs) to increase drug retention outer skin layers improve safety of therapy. NLCs were prepared using microemulsion technique with mixture lecithin, taurodeoxycholate, stearic acid, oleic acid. vitro penetration studies performed modified Franz-type diffusion cell, porcine ears used as model human...
The isoflavone genistein (GEN) is a natural product with potential applications for skin cancer treatment and chemoprevention; however its high lipophilicity chemical instability limits clinical use. Therefore, attempts towards protecting GEN against degradation increasing penetration in the might be valid approach. In this work, loaded-PLA nanocapsules (GEN-NC) were prepared by interfacial deposition of preformed polymer (nanoprecipitation); physicochemical characterization stability...
Background: Lipid nanoparticles have been extensively studied for drug delivery of antifungal drugs, especially dermatophytosis treatments. They can accumulate in skin appendages and release drugs a controlled manner also increase moisture, due to the formation an occlusive film. Since moisture heavily influences nail permeability, these systems seem pose great potential delivery. Methods: We therefore compare physiopathological structure discuss use lipid managing mycoses, highlighting...