A5031984228- Carbohydrate Chemistry and Synthesis
- NMR spectroscopy and applications
- Glycosylation and Glycoproteins Research
- Molecular spectroscopy and chirality
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Advanced NMR Techniques and Applications
- Surfactants and Colloidal Systems
- Advanced Drug Delivery Systems
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Chemical Synthesis and Analysis
- Supramolecular Chemistry and Complexes
- Concrete and Cement Materials Research
- Proteins in Food Systems
- Ocular Surface and Contact Lens
- Computational Drug Discovery Methods
- Molecular Sensors and Ion Detection
- Ionic liquids properties and applications
- Bee Products Chemical Analysis
- Monoclonal and Polyclonal Antibodies Research
- Crystallization and Solubility Studies
- Advanced MRI Techniques and Applications
- Prion Diseases and Protein Misfolding
- Drug Solubulity and Delivery Systems
Universidade de Santiago de Compostela
2013-2023
Universidade da Coruña
2019
Centro Singular de Investigación en Química Biológica y Materiales Moleculares
2011-2016
Center for Research in Molecular Medicine and Chronic Diseases
2016
Universidad de Santiago de Chile
2015
Instituto de Investigación Sanitaria de Santiago
2012
Complejo Hospitalario Universitario de Santiago
2012
Universidade Estadual de Campinas (UNICAMP)
2010
Universidade Federal da Bahia
2010
Leipzig University
2002-2010
This report describes the synthesis of ionic liquids that incorporate N-methyl-2-hydroxyethylammonium cation with various carboxylic acid anions and study some their physical properties, including self-diffusion coefficients, density, speed sound, viscosity, refractive index. 1H 13C NMR spectra were used to characterize chemical structure species in concordance FT-IR spectra. DOSY was determine coefficients components, which consistent formation a lamellar or micellar liquid-crystal phase...
Abstract Recent computational advancements in the simulation of biochemical processes allow investigating mechanisms involved protein regulation with realistic physics-based models, at an atomistic level resolution. These techniques allowed us to design a drug discovery approach, named Pharmacological Protein Inactivation by Folding Intermediate Targeting (PPI-FIT), based on rationale negatively regulating levels targeting folding intermediates. Here, PPI-FIT was tested for first time...
The main purpose of the present work was to apply NMR techniques characterize nanostructural organization a new drug nanocarrier composed tripalmitin, lecithin, and poly(ethylene glycol) (PEG)-stearate. These nanocarriers were prepared by an emulsification−solvent evaporation technique characterized for their composition architecture. results showed that in core nanoparticles, is component these systems, whereas PEG-stearate firmly attached surface forming hydrated polymeric layer....
NMR is a powerful tool to study the dynamics of dendrimers. By analogy linear polymers, shorter T1 relaxation times have been traditionally associated less mobile nuclei and hence, dendrimers described with reduced local motions at either core or periphery. Herein we report [1H 13C T1, T2; 13C{1H}NOE; various fields temperatures] which reveals profound differences between behavior polymers. Dendrimers show slower internal layers on increasing generation may display in slow motional regime...
A new type of sugar-amino acid hybrid, which is comprised a sugar unit (gluco-, galacto-, or mannopyranose) linked through C-glycosidic linkage to the β-position an α-unsubstituted β-amino unit, presented. It hypothesized that these compounds, oligomeric peptides derived therefrom, might possess structural features oligomers and chemical enzymatic resistance C-glycosides hydrolysis. The synthetic strategy based on Mannich-type reaction between chiral acetate enolate equivalent α-amido...
The self-aggregation of five amphiphilic p-sulfonatocalix[n]arenes bearing alkyl chains at the lower rim was investigated by NMR spectroscopy and electrical conductivity. critical micelle concentration determined, tendency this special class surfactants to self-aggregate in aqueous solution analyzed as a function chain length number aromatic units macrocyclic ring. structure monomeric micellized states elucidated means (1)H and, case calix[6]arene derivative, with 2D experiments. While all...
In this work, we have studied the interactions between water-soluble p-sulfonatocalix[6]arene and cationic surfactants octyltrimethylammonium bromide below cmc dodecyltrimethylammonium above cmc, by saturation transfer difference (STD) NMR spectroscopy. From STD build-up curves, obtained T1 independent cross relaxation rates, results show that established headgroup of surfactant OMe group macrocycle play an important role in stabilization complex, both cmc.
Biodegradable poly(lactic-co-glycolic acid) microspheres (PLGA MSs) are attractive delivery systems for site-specific maintained release of therapeutic active substances into the intravitreal chamber. The design, development, and characterization idebenone-loaded PLGA by means an oil-in-water emulsion/solvent evaporation method enabled obtention appropriate production yield, encapsulation efficiency loading values. MSs revealed spherical shape, with a size range 10-25 μm smooth non-porous...
The conformational behavior of the synthetic glycosidase inhibitor C-lactose (1) has been studied in different solvents (water, N,N-dimethylformamide, dimethyl sulfoxide, pyridine) using NMR spectroscopy and molecular mechanics calculations. obtained results have compared to those previously for its natural analogue, methyl α-lactoside (2). It is shown that C- O-lactoses only similar around glycosidic bond, but not aglyconic bond. In addition, extent flexibility β(1→4) linkage much larger...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular Recognition of Carbohydrates Using a Synthetic Receptor. A Model System to Understand the Stereoselectivity Carbohydrate-Carbohydrate Interaction in WaterJesus Jimenez-Barbero, Elena Junquera, Manuel Martin-Pastor, Sunil Sharma, Cristina Vicent, and Soledad PenadesCite this: J. Am. Chem. Soc. 1995, 117, 45, 11198–11204Publication Date (Print):November 1, 1995Publication History Published online1 May 2002Published inissue 1 November...
Abstract The conformations of the histo‐blood group carbohydrate antigens Lewis X (Le x ) and A a were studied by NMR measurements one‐bond C—H residual dipolar couplings in partially oriented liquid crystal solutions. strategy for rapid calculation difference between theoretical experimental large number model structures generated computer simulations was developed, resulting an accurate structure compounds. Monte Carlo used to generate models trisaccharides, orientations each sought that...
1H−13C one-bond dipolar coupling values were measured for natural abundance samples of the human milk oligosaccharides "lacto-N-fucopentaose" (LNF-1 LNF-2, and LNF-3), "lacto-N-difucohexaose" (LND-1), "lacto-N-tetraose" (LNT), "lacto-N-neo-tetraose" (LNnT), four which have Lewis blood group epitopes. Each oligosaccharide was dissolved in a 7.5% solution 1,2-dimyristoyl-sn-glycero-3-phosphocholine/1,2-dihexanoyl-sn-glycero-3-phosphocholine (DMPC/DHPC) bicelle liquid crystals oriented NMR...
This study aimed to monitor the effect of temperature and addition nanosilica on nanostructure C – S H gel forming during tricalcium silicate ( 3 ) hydration. Two types paste were prepared from a synthesized T 1 . The first consisted blend deionized water at water/solid ratio 0.425. In second, 90 wt% + 10 was mixed with 0.7. pastes stored in closed containers 100% RH 25°C, 40°C, or 65°C. hydration reaction detained after 1, 14, 28, 62 d acetone, then studied by 29 Si magic angle spinning...