A5048375860- Birth, Development, and Health
- Hormonal and reproductive studies
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Effects and risks of endocrine disrupting chemicals
- Tissue Engineering and Regenerative Medicine
- Sexual Differentiation and Disorders
- Insect and Arachnid Ecology and Behavior
- Sperm and Testicular Function
- Insect and Pesticide Research
- Prostate Cancer Treatment and Research
- Pregnancy and preeclampsia studies
- Protease and Inhibitor Mechanisms
- Bone health and treatments
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Cancer Cells and Metastasis
- Reproductive Biology and Fertility
- Renal and related cancers
- Digestive system and related health
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
Universidade Estadual Paulista (Unesp)
2016-2025
Fox Chase Cancer Center
2022-2025
Instituto de Biología Subtropical
2019
Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown various antitumor properties. Herein, we investigated influence of therapy on energy metabolism mitochondrial integrity in SKOV-3 cells tested whether its effects depended MT1 receptor activation. were exposed to different concentrations, experimental groups divided as presence receptors (melatonin groups) or absence by RNAi silencing (siRNA MT1+melatonin). Intracellular levels increased after treatment...
ABSTRACT Parabens are chemicals used as preservatives in food, personal care products, and pharmaceuticals. Detectable paraben levels found water, air, soil, making human animal exposure unavoidable. This study evaluated the effects of methylparaben, propylparaben, their mixture on prostate gonads male female gerbils. Gerbils aged 90 days were assigned to groups: (M) 10 mg/kg/day methylparaben; (P) propylparaben; (M + P) 5 methylparaben plus (C) control group. The animals treated orally for...
To evaluate whether the joint use of autologous platelet-rich plasma (aPRP) and rosuvastatin (RSV) in biopsies dermal wounds induced rabbits results an additive effect on immunoexpression collagens type I III, optimizing healing process increasing collagen production during proliferative phase to improve quality tissue repair. Thirty-two biopsy samples from eight clinically healthy adult male New Zealand were used. They treated with aPRP, RSV, or aPRP + RSV analyzed zero, three, seven, ten,...
Carcinogenesis is frequently linked to genetic background, however, exposure environmental risk factors has gained attention as the etiologic agent for several types of cancer, including prostate. The intrauterine microenvironment been described a preponderant factor offspring health; and maternal insult chronic disease in older offspring. Using model low-protein diet (LPD; 6% protein), we demonstrated that impairment rat prostatic growth on postnatal day (PND) 21 was associated with...
Abstract Understanding pancreatic cancer biology is fundamental for identifying new targets and developing more effective therapies. In particular, the contribution of stromal microenvironment to tumorigenesis requires further exploration. Here, we report roles synaptic protein Netrin G1 Ligand (NGL-1) in cancer, uncovering its pro-tumor functions cancer-associated fibroblasts immune cells. We observed that expression NGL-1 inversely correlated with patients’ overall survival. Moreover,...
The developmental origins of health and disease concept links adult diseases with early-life exposure to inappropriate environmental conditions. Intrauterine postnatal malnutrition may lead an increased incidence type 2 diabetes, obesity, cardiovascular diseases. Maternal (MM) has also been associated prostate carcinogenesis. However, the molecular mechanisms this condition remain poorly understood. Using a proteomic analysis, we demonstrated that MM changed levels proteins growth factors,...
We investigated the impact of diabetes with simultaneous and late insulin replacement on rat prostate growth during puberty, paying special attention to different prostatic lobes. Diabetes was induced by administration streptozotocin (STZ) in 40-day-old male Wistar rats. A subset diabetic rats underwent (3 days after STZ administration), another a (20 administration). The ventral, dorsolateral, anterior lobes were weighed processed for histological, immunohistochemical, morphometric...
Summary Despite recent advances in understanding the biological basis of prostate cancer ( PC a), management this disease remains a challenge. Chemoprotective agents have been used to protect against or eradicate malignancies. Here, we investigated protective effect γ‐tocopherol on N ‐methyl‐ ‐nitrosourea MNU )‐induced epithelial dysplasia rat ventral VP ). Thirty‐two male Wistar rats were divided into four groups n = 8): control CT ): healthy animals fed standard diet; control+γ‐tocopherol...
The gerbil female prostate undergoes morphological and physiological changes resulting from hormonal fluctuations that occur during the reproductive cycle. These repetitive cycles of glandular growth regression are followed by an extensive reconstruction remodeling stroma throughout life gerbil. objective this study was to evaluate effect cycle have on stromal expression activity matrix metalloproteinases MMP-2 -9 in adult prostate. For this, serological, ultrastructural, immunohistochemical...
The interaction between bacteriophages and integrins has been reported in different cancer cell lines, efforts have undertaken to understand these interactions tumor cells along with their possible role gene alterations, the aim develop new therapies. Here, we report that non-specific of T4 M13 human PC-3 results differential migration varied expression integrins. (at 70% confluence) were exposed 1 × 107 pfu/mL either lytic bacteriophage or filamentous bacteriophage. After 24 h exposure,...
Abstract The possibility of chemical contamination is an important issue to consider when designing a cell therapy strategy. Both bisphenol A (BPA) and 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) are among the most environmentally relevant endocrine disrupting chemicals (EDCs, compounds with high affinity for adipose tissue) recently studied. Adipose‐derived stem cells (ASCs) mesenchymal stromal (MSCs) obtained from tissue widely used in regenerative medicine prevent treat diseases several...