A5029740930- Essential Oils and Antimicrobial Activity
- Ethnobotanical and Medicinal Plants Studies
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Pharmacological Effects of Medicinal Plants
- Analytical Chemistry and Chromatography
- Microbial Natural Products and Biosynthesis
- Phytochemicals and Antioxidant Activities
- Phytochemicals and Medicinal Plants
- Phytochemistry and Bioactive Compounds
- Phytochemistry and Biological Activities
- Pomegranate: compositions and health benefits
- Bee Products Chemical Analysis
- Marine Sponges and Natural Products
- Plant-Derived Bioactive Compounds
- Research on Leishmaniasis Studies
- Natural Antidiabetic Agents Studies
- Chemical synthesis and alkaloids
- Sesquiterpenes and Asteraceae Studies
- Phytochemical Studies and Bioactivities
- Toxin Mechanisms and Immunotoxins
- Ginkgo biloba and Cashew Applications
- Antimicrobial agents and applications
- Morinda citrifolia extract uses
- Heavy Metals in Plants
Universidade Estadual Paulista (Unesp)
2017-2025
Universidade de São Paulo
2023-2024
Universidade Federal de Alfenas
2023
University of Strathclyde
2023
Natura (Brazil)
2023
Centro Universitário de Araraquara
2017-2022
Hospital São Vicente
2018
The Feature-based Molecular Networking (FBMN) is a well-known approach for mapping and identifying structures analogues. However, in the absence of prior knowledge about molecular class, assessing specific fragments clusters requires time-consuming manual validation. This study demonstrates that combining FBMN Mass Spec Query Language (MassQL) an effective strategy accelerating decoding mass fragmentation pathways molecules with comparable patterns, such as beauvericin its To accomplish this...
Seasonality is one of the major environmental factors that exert influence over synthesis and accumulation secondary metabolites in medicinal plants. The application metabolomics approach for quality control plant extracts essentially important because it helps to establish a standard metabolite profile analyze affect effectiveness Brazilian Cerrado flora characterized by rich diversity native species, number these species have been found suitable properties. Some include Byrsonima...
Phenolic compounds have been scientifically recognized as beneficial to intestinal health. The cactus Nopalea cochenillifera, used anti-inflammatory in traditional medicine, is a rich source of these bioactive compounds. present study aimed investigate the phytochemical profile N. cochenillifera extract and evaluate its acute toxicity effect on 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis rats. total phenolic content per gram dry was 67.85 mg. Through HPLC-IES-MSn, 25 such...
Byrsonima intermedia is a species of bush popularly used to treat gastrointestinal disorders, such as gastric ulcers, gastritis, and diarrhea. Previous studies have revealed that the methanolic crude extract B. leaves has gastroprotective healing properties. In this new study, we specifically investigated two purified partitions, ethyl acetate (EtOAc) water (AcoAq), obtained from characterize antiulcer effects these partitions mechanisms action medicinal plant. The on duodenal mucosa were...
Croton urucurana Baill. (Euphorbiaceae) is a plant used in Brazilian popular medicine for the treatment of wound healing, inflammatory diseases, gastritis, infections, and hemorrhoids.The present study aimed to evaluate vivo healing activity an ointment based on ethanolic extract C. stem bark, at concentrations 5% 10%, relate it with compounds that could be associated this activity.Analyses by FIA-ESI-IT-MSn were carried out investigate chemical composition urucurana. Knockout IL-10 (n = 60)...
The guided tissue regeneration (GTR) technique can be applied in dentistry and other medical specializations, such as orthopedics. In modern dentistry, GTR has been used periodontics implantology to treat periodontal defects, reconstruct lost, damaged atrophied bone dental implant procedures, preserve alveolar bases after tooth extraction. order create improve new therapies develop biomaterials that restore, prevent aggravation of compromised function, poly (ϵ-caprolactone) (PCL) polymer...
Commiphora leptophloeos (Burseraceae) is a medicinal plant native to Brazil which popularly used for treating oral and vaginal infections. There has been no scientific evidence pointing its efficacy in the treatment of these Thus, this study sought investigate cytotoxic, antifungal, antibiofilm activity C. against Candida spp. isolate, identify, quantify content B-type oligomeric procyanidins (BDP) extract stem bark. The n -butanol fraction were obtained by maceration liquid-liquid...
Seed exudates are plant-derived natural bioactive compounds consisting of a complex mixture organic and inorganic molecules. Plant seed have been poorly studied against parasite nematodes. This study was undertaken to identify proteins in the Myracrodruon urundeuva assess anthelmintic activity Haemonchus contortus, an important small ruminants. M. (SEX) obtained after immersion seeds sodium acetate buffer. SEX fractionated with ammonium sulfate at 0–90% concentration generate ressuspended...
Virola elongata is a tree species belonging to the Myristicaceae family, distributed in North and Midwest regions of Brazil, phytogeographic domain Amazon. The aqueous infusion or hydroethanolic macerate stem bark V. are used Brazilian Ecuadorian indigenous folk medicine for several ethnopharmacological purposes, principally, treatment stomach pain, indigestions, gastric ulcers. This study was aimed investigate gastroprotective activity this plant order support its popular use with...
Terminalia catappa L. (Combretaceae) is a medicinal plant that part of the Brazilian biodiversity; this popularly used for treatment wide range diseases. To better understand chemical composition T. in different seasons, we conducted thorough study using LC-MS and NMR data analysis techniques. The helped obtain profile ethanolic extracts seasons year (spring, summer, autumn, winter). dereplication LC-HRMS allowed annotation 90 compounds (hydrolyzable tannins, ellagic acid derivatives,...
Terminalia catappa L. (Combretaceae), known as "amendoeira da praia" in Brazil, has been recognized a medicinal plant folk medicine for the treatment of gastrointestinal disorders and other inflammatory conditions. The present study aimed to investigate preventive healing effects infusion leaves T. (ILTC) against gastric lesions caused by ischemia reperfusion (I/R) injury characterize its mechanism action mucosa rats. Different doses (30, 100, 300 mg/kg) ILTC were orally administered acute...
Summary Plant biodiversity is a source of potential natural products for the treatment many diseases. One ways discovering new drugs through cytotoxic screening extract libraries. The present study evaluated 196 extracts prepared by maceration Brazilian Atlantic Forest trees with organic solvents and distilled water antimetastatic activity. MTT assay was used to screen activity in MCF‐7, HepG2 B16F10 cancer cells. highest had activity, as determined vitro assays melanoma murine model. leaves...
Several medicinal plants have drawn the attention of researchers by its phytochemical composition regarding their potential for treating chronic complications diabetes mellitus. In this context, Myrtaceae family popularly used in Brazil treatment mellitus, including Eugenia sonderiana, shown beneficial effects due to presence phenolic compounds and saponins chemical constitution. Thus, present work aimed perform characterization hydroethanolic extract E. sonderiana leaves using...
Rationale Actinocephalus divaricatus (Eriocaulaceae) is an important source of income for rural communities as it sold ornamental plant. To date, no investigation has been conducted concerning the chemical composition and biological studies aerial parts A. . Methods The methanolic extract this species was chemically characterized. We applied analytical dereplication approach based on Liquid Chromatography coupled to High‐Resolution Orbitrap Mass Spectrometry in order develop, identify define...
Abstract Introduction Soybean is one of the most important crops in world, an source isoflavones, and used to treat various chronic diseases. High‐performance liquid chromatography (HPLC), associated with multivariate experiments green solvents, increasingly develop comprehensive elution methods for quality control plants derivatives. Objective The work aims establish a HPLC fingerprinting method soybean seeds employing Green Chemistry Principles, sustainable solvent low toxicity,...
Athenaea velutina is a promising Brazilian shrub with cytotoxic and antimigratory properties against cancer cells. However, the mechanism of induction cell death compounds involved remain unknown. To ascertain these bioactive compounds, bioassay-guided fractionation was performed, alongside appropriate in vitro tests. A withanolide-rich fraction (FAv_5) from dichloromethane extract increased activity by 1.5-fold (IC50 = 2.1 µg/mL). Fourteen withanolide steroids were tentatively identified...
The analysis by HPLC-PDA of the hydroalcoholic extract leaves M. eriocarpum together with injection fractions containing already identified metabolites allowed detection at least 5 flavonoids, which two are derived from apigenin and three luteolin. After isolating larger amounts isovitexin (I), assays were performed to evaluate allelopathic activity crude extract. results show that initial inhibition indexes very similar those observed in treatments F17 (Fraction enriched isovitexin) F18...
Solanum paniculatum L. is widely used in Brazilian folk medicine for the treatment of liver and gastrointestinal disorders as well culinary purposes beverage production. Fractionation hydroalcoholic [ethanol (EtOH) 70%] tincture from S. leaves led to isolation six new spirostanic saponins which included 6- O-α-l-rhamnopyranosyl-(1''→3')-β-d-quinovopyranosyl-(22 S,23 R,25 S)-3β,6α,23-trihydroxy-5α-spirostane (1), O-β-d-xylopyranosyl-(1''→3')-β-d-quinovopyranosyl-(22...