A5082619307- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Dermatology and Skin Diseases
- HIV Research and Treatment
- Ocular Surface and Contact Lens
- Nanofabrication and Lithography Techniques
- 3D Printing in Biomedical Research
- Advanced Biosensing Techniques and Applications
- HIV/AIDS drug development and treatment
- Lipid Membrane Structure and Behavior
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Advanced Fluorescence Microscopy Techniques
- Additive Manufacturing and 3D Printing Technologies
- Biological Stains and Phytochemicals
- Plant-Derived Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Bone health and treatments
- Bioactive Compounds and Antitumor Agents
- Skin Protection and Aging
- Electrospun Nanofibers in Biomedical Applications
- Osteoarthritis Treatment and Mechanisms
- Bee Products Chemical Analysis
- Natural product bioactivities and synthesis
Queen's University Belfast
2018-2024
University of Ulster
2024
Universidade Estadual de Campinas (UNICAMP)
2018-2024
Queens University
2022
Universidade Estadual Paulista (Unesp)
2012
Centro Universitário de Araraquara
2012
Oral administration and intramuscular (IM) injection are commonly recommended options for human immunodeficiency virus (HIV) treatment. However, poor patient compliance due to daily oral dosing, pain at sites the demand trained healthcare staff injections limit success of these routes, especially in low-resource settings. To overcome limitations, first time, we propose novel bilayer dissolving microneedles (MNs) intradermal delivery long-acting nanosuspensions antiretroviral (ARV) drug...
Abstract Purpose To apply a simple and flexible manufacturing technique, two-photon polymerisation (2PP), to the fabrication of microneedle (MN) array templates with high precision low cost in short time. Methods Seven different MN were produced by 2PP 3D printing, varying needle height (900–1300 μm), shape (conical, pyramidal, cross-shaped pedestal), base width (300–500 μm) interspacing (100–500 μm). Silicone moulds fabricated from these used produce dissolving hydrogel-forming arrays....
A key challenge of HIV treatment with multiple antiretroviral drugs is patient adherence. Thus, there an urgent need for long-acting depot systems delivering over extended duration. Although the parenteral route preferred systems, it associated obvious drawbacks, such as painful injections, potentially-contaminated sharps waste, and necessity trained healthcare personnel administration. Amongst a small number alternatives in development microneedles are versatile delivery enabling systemic...
Abstract Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with over two‐thirds promising new chemical entities failing to enter a clinical setting due solubility issues. Although oral formulations have made some impact, alternative enhancement strategies for administration such molecules are actively sought. Over the last decade, innovation on global scale has enabled expansion frontiers microarray patches (MAPs) further ever before. Initially designed load...
Abstract Injectable long‐acting cabotegravir (CAB LA) is effective and safe for pre‐exposure HIV prophylaxis. It recently approved clinical use in those at high risk of contracting HIV. However, injections are invasive access to trained healthcare personnel administer CAB LA can be limited, especially low‐income countries (LICs). Herein, the first time, development a bilayer microarray patch (MAP) with unique design novel formulation as potential alternative self‐administrated intradermal...
Hydrogel-forming microarray patches (HF-MAPs) offer minimally invasive, pain-free and prolonged drug delivery. These devices are designed to be self-administered self-disabling, avoiding contaminated sharps waste generation. Cabotegravir sodium (CAB-Na) is a poorly soluble anti- human immunodeficiency virus (HIV) for the treatment pre-exposure prophylaxis of HIV infection that lends itself depot formation following intradermal delivery but presents significant challenges when delivered via...
The human immunodeficiency virus (HIV) remains a global health concern, with 37.7 million people currently living the infection and 1.5 new cases every year. Current antiretroviral (ARV) therapies are administered through oral route daily, often in lifelong treatments, leading to pill fatigue poor treatment adherence. Therefore, development of novel formulations for administration ARV drugs using alternative routes is actively sought out. In this sense, microneedle array patches (MAPs) offer...
The lymphatic system possesses the main viral replication sites in body following infection. Unfortunately, current antiretroviral agents penetrate lymph nodes insufficiently when administered orally and, therefore, cannot access sufficiently to interrupt this replication. For reason, novel drug delivery systems aimed at enhancing uptake of drugs are highly desirable. Dissolving polymeric microarray patches (MAPs) may help target intradermally. MAPs intradermal used deliver many types...
Microarray patches (MAPs) have shown great potential for efficient and patient-friendly drug delivery through the skin; however, improving their efficiency long-acting release remains a significant challenge. This research provides an overview of novel strategies aimed at enhancing MAP micronized cabotegravir sodium (CAB Na) HIV pre-exposure prophylaxis (PrEP). The refinement microneedle design parameters, including needle length, shape, density, arrangement, formulation properties, such as...
Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both humans and animals' lives. Current treatment of CE oral administration albendazole (ABZ) hampered several limitations. The poor aqueous solubility the rapid metabolism ABZ in liver are main issues, leading to lack efficacy treatment. In present study, we developed nanocrystalline (NC) formulation be delivered intradermally using dissolving microneedles (DMNs). NC was milling an ultrasmall-scale device....
Implantable drug delivery systems offer an alternative for the treatments of long-term conditions (i.e. schizophrenia, HIV, or Parkinson's disease among many others). The objective present work was to formulate implantable devices loaded with model hydrophobic olanzapine (OLZ) using robocasting 3D-printing combined a pre-formed rate controlling membrane. OLZ selected as molecule due its nature and because is good example used treat chronic condition schizophrenia. resulting implants...
Melanoma remains a global concern, but current therapies present critical limitations pointing out the urgent need for novel strategies. Among these, cutaneous delivery of drugs selectively damaging cancer cells is highly attractive. Rose Bengal (RB) dye exhibiting selective cytotoxicity towards melanoma, high water solubility and low permeability hinder its therapeutic potential. We previously developed RB-loaded transfersomes (RBTF) to mediate RB dermal delivery; however, platform...
Implantable drug-eluting devices that provide therapeutic cover over an extended period of time following a single administration have potential to improve the treatment chronic conditions. These eliminate requirement for regular and frequent drug administration, thus reducing pill burden experienced by patients. Furthermore, use modern technologies, such as 3D printing, during implant development manufacture renders this approach well-suited production highly tuneable can deliver regimens...
Transdermal drug delivery is an alternative route of administration that offers avoidance the associated drawbacks orally and parenterally administered hydrophobics. However, owing to extremely specific set physicochemical characteristics required for passive transdermal permeation, development marketed products containing poorly soluble drugs has been severely limited. Microarray patches (MAPs) are a type patch differ from traditional design due presence tiny, micron-sized needles permit...
Malaria is a global parasitic infection that leads to substantial illness and death. The most commonly-used drugs for treatment of malaria vivax are primaquine chloroquine, but they have limitations, such as poor adherence due frequent oral administration gastrointestinal side effects. To overcome these we developed nano-sized solid dispersion-based dissolving microarray patches (MAPs) the intradermal delivery drugs. In vitro testing showed systems can deliver skin receiver compartment up...
The retinoid fenretinide (FENR) is a promising compound for preventing breast cancer recurrence but faces challenges due to poor solubility and low bioavailability. This study explores the development of dissolving microneedles (MNs) containing FENR-loaded ethosomes minimally invasive chemoprevention, aiming enhance local drug distribution. Ethosomes were formulated using ethanol, propylene glycol, soya lecithin, water, polysorbate 80 micelles. MNs created from poly(vinyl alcohol)...
Whilst significant progress has been made to defeat HIV infection, the efficacy of antiretroviral (ARV) therapy in paediatric population is often hindered by poor adherence. Currently, two long-acting (LA) intramuscular injectable nanosuspensions rilpivirine (RPV) and cabotegravir (CAB) are clinical development for populations. However, administration requires access healthcare resources, painful, can result needle-stick injuries end user. To overcome these barriers, this proof-of-concept...
The role of microneedle array patches (MAPs) and, in particular, dissolving MAPs transdermal drug delivery has increased exponentially over the last decade. are able to form depots viable skin from where poorly soluble drugs dissolve a long-acting fashion, showing promise management multiple diseases. manufacture these systems can present some challenges, including presence bubbles baseplates and consequent lack uniformity formation content. Here, we simple method based on ring inserts...