A5058330774- Advancements in Transdermal Drug Delivery
- Immunotherapy and Immune Responses
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Dermatology and Skin Diseases
- Ocular Surface and Contact Lens
- Bee Products Chemical Analysis
- Botulinum Toxin and Related Neurological Disorders
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical Chemistry and Sensors
- Nonmelanoma Skin Cancer Studies
- 3D Printing in Biomedical Research
- Skin Protection and Aging
- Hydrogels: synthesis, properties, applications
- Advanced biosensing and bioanalysis techniques
- Advanced Fluorescence Microscopy Techniques
- Phytoestrogen effects and research
- Silk-based biomaterials and applications
- Polysaccharides and Plant Cell Walls
- SARS-CoV-2 and COVID-19 Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Slime Mold and Myxomycetes Research
- Protein Interaction Studies and Fluorescence Analysis
- Contact Dermatitis and Allergies
- Immune Cell Function and Interaction
De Montfort University
2021-2025
Universidade de Santiago de Compostela
2012-2021
Center for Research in Molecular Medicine and Chronic Diseases
2012-2021
Queen's University Belfast
2018-2020
Instituto de Investigación Sanitaria de Santiago
2015
Servicio Gallego de Salud
2015
Universidade do Porto
2012
Abstract Purpose To apply a simple and flexible manufacturing technique, two-photon polymerisation (2PP), to the fabrication of microneedle (MN) array templates with high precision low cost in short time. Methods Seven different MN were produced by 2PP 3D printing, varying needle height (900–1300 μm), shape (conical, pyramidal, cross-shaped pedestal), base width (300–500 μm) interspacing (100–500 μm). Silicone moulds fabricated from these used produce dissolving hydrogel-forming arrays....
The development of a self-regulated minimally invasive system for insulin delivery can be considered as the holy grail in field diabetes mellitus. A capable releasing response to blood glucose levels would significantly improve quality life diabetic patients, eliminating need frequent finger-prick tests and providing better glycaemic control with lower risk hypoglycaemia. In this context, latest advances glucose-responsive microneedle-based transdermal are here compiled thorough analysis...
Abstract: Despite vaccination representing one of the greatest advances modern preventative medicine, there remain significant challenges in vaccine distribution, delivery and compliance. Dissolvable microarray patches or dissolving microneedles (DMN) have been proposed as an innovative platform that could potentially revolutionize circumvent many faced with current strategies. DMN, due to their ease use, lack elicitation pain response, self-disabling nature transport offer attractive option...
The focus on novel systems for transdermal delivery of therapeutic agents has increased considerably over recent years, as this administration route comes with many advantages. Polymeric microarray patches (MAPs) are minimally invasive devices that enable systemic a wide range drugs by overcoming the outer skin barrier. Conventionally, MAPs fabricated micromoulding have low needle density. In study, performance hydrogel-forming cast using industrially manufactured micromoulds high density...
Polymer-based nanocarriers have shown potential for enhancing the immunological response of antigens. However, key drivers this not been fully elucidated. The objective work was to evaluate influence particle size (≈100 versus 200 nm) and surface composition polymeric nanocapsules (chitosan, polyarginine carboxymethyl-β-glucan) on their ability target specific immune cells in lymphatics. For purpose, we used a powerful imaging technique, two-photon intravital microscopy, which minimises...
We report, for the first time, crosslinked polymeric microneedle (MN) arrays and single needles (2 mm 4.5 length) coated with gold nanorods (GnRs) to induce deep hyperthermia in a 3 mm-thickness skin model upon near infrared (NIR) laser irradiation.
Two groups of single polymeric needles (crosslinked Gantrez®S-97 and poly(ethylene glycol)) different lengths (2 mm 4.5 mm) with defined base widths were fabricated tested in terms their mechanical strength insertion abilities using two skin models (Parafilm® porcine skin). For the shorter needles, application an axial force (32 N) resulted a height reduction approximately 80%. Nonetheless, around 80% total needle length was successfully inserted both models. Optical coherence tomography...
Current strategies for the treatment of superficial non-melanoma skin cancer (NMSC) lesions include topical imoquimod, 5-fluorouracil, and photodynamic therapy. Although these treatments are effective, burning pain, blistering, dermatitis have been reported as frequent side effects, making therapies far from ideal. Plasmonic materials investigated induction hyperthermia use in treatment. In this sense, effectiveness intratumorally systemically injected gold nanorods (GnRs) inducing cell...