A5055957167- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Advanced Drug Delivery Systems
- Bee Products Chemical Analysis
- Skin Protection and Aging
- Essential Oils and Antimicrobial Activity
- Contact Dermatitis and Allergies
- Acne and Rosacea Treatments and Effects
- Drug Solubulity and Delivery Systems
- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Phytochemicals and Antioxidant Activities
- Pesticide Residue Analysis and Safety
- Effects of Radiation Exposure
- Wound Healing and Treatments
- Psidium guajava Extracts and Applications
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Analytical Methods in Pharmaceuticals
- Coffee research and impacts
- Natural product bioactivities and synthesis
- Nanoparticle-Based Drug Delivery
- Proteins in Food Systems
Universitat de València
2016-2025
Universidad de Navarra
2021
Clinica Universidad de Navarra
2021
Helmholtz Institute for Pharmaceutical Research Saarland
2011-2016
Biomechanics Institute of Valencia
2016
Saarland University
2007-2012
Hospital Virgen del Valle
1989
Abstract Antimicrobial resistance and tolerance (AMR&T) are urgent global health concerns, with alarmingly increasing numbers of antimicrobial drugs failing a corresponding rise in related deaths. Several reasons for this situation can be cited, such as the misuse traditional antibiotics, massive use sanitizing measures, overuse antibiotics agriculture, fisheries, cattle. AMR&T management requires multifaceted approach involving various strategies at different levels, patient’s...
The development of a self-regulated minimally invasive system for insulin delivery can be considered as the holy grail in field diabetes mellitus. A capable releasing response to blood glucose levels would significantly improve quality life diabetic patients, eliminating need frequent finger-prick tests and providing better glycaemic control with lower risk hypoglycaemia. In this context, latest advances glucose-responsive microneedle-based transdermal are here compiled thorough analysis...
Costimulation via CD137 (4-1BB) enhances antitumor immunity mediated by cytotoxic T lymphocytes. Anti-CD137 agonist antibodies elicit mild liver inflammation in mice, and the maximum tolerated dose of Urelumab, an anti-human monoclonal antibody, clinic was defined inflammation-related side effects. A protease-activated prodrug form anti-mouse antibody 1D8 (1D8 Probody therapeutic, Pb-Tx) constructed found to be selectively activated tumor microenvironment. This construct, which encompasses a...
Trans-resveratrol (RES) is a natural polyphenol known for its antioxidant, anti-inflammatory, and anti-aging properties, making it highly valuable in cosmetic applications. Solid lipid nanoparticles (SLNs) offer promising solution to enhance RES’s stability cutaneous availability. This study aimed develop characterize SLNs encapsulating RES enhanced skin delivery. Multiple methodologies were evaluated determine the impact of preparation methods on formulation stability. formulated using...
The deposition of drug-loaded nanoparticles within the skin structure has been a challenge due to inexorable barrier function. Unless specific like liposomes and lipid-based related vesicles, most cannot penetrate epidermal layers by themselves. This is reason why microneedle-based systems are nowadays straightforward in research. They can greatly bypass stratum corneum deposit supramolecular cargo entities dermal layers, which perform features such as drug-controlled release, targeting or...
Atopic dermatitis (AD) and psoriasis are the most common chronic inflammatory skin disorders, which importantly affect quality of life patients who suffer them. Among other causes, nitric oxide has been reported as part triggering factors in pathogenesis both conditions. Cyanocobalamin (vitamin B12) shown efficacy a scavenger some clinical trials have given positive outcomes its use for treating pathologies. Passive diffusion is possible only drugs with low molecular weights intermediate...
<b><i>Aims:</i></b> The influence of nanoencapsulation mometasone furoate (MF) in poly(ε-caprolactone) lipid-core nanocapsules (LNC) on its vitro human skin permeation and penetration was evaluated. <b><i>Methods:</i></b> Semisolid formulations were prepared by increasing the viscosity LNC using a carbomer (Carbopol® Ultrez at 0.5% w/v). Two complementary techniques (the static Franz diffusion cell model Saarbrücken model) used to evaluate...
Guava (Psidium guajava L.) is a native fruit of the American tropics with commercial applications for its taste, flavor and aroma. Numerous pharmacological uses have been described it, such as antiseptic effect leaves, use fresh tea from leaves treatment diarrhea, dysentery, diabetes mellitus, others. However, considering rich composition, guava also potential source antioxidants to be used in development new formulations cosmetic and/or dermatological applications, main focus this research....
Vitamin B12 (cyanocobalamin) deficiency is a widespread condition because of its different aetiologies, like malabsorption syndrome or lifestyles as strict veganism that increasing incidence and prevalence in developed countries. It has important haematological consequences require pharmacological treatment. Current therapy consists oral parenteral supplements cyanocobalamin; however, the route discarded for patients not well accepted generally. Topical treatments have been suggested an...
An increased interest in colonic drug delivery has led to a higher focus on the design of devices targeting this part gastrointestinal tract. Microcontainers have previously facilitated an increase oral bioavailability drugs. The surface texture and shape microcontainers proven influence mucoadhesion ex vivo. In present work, these findings were further investigated using situ closed-loop perfusion technique rat colon, which allowed for simultaneous evaluation as well absorption....