A5074574029- Advancements in Transdermal Drug Delivery
- Advanced MEMS and NEMS Technologies
- Dermatology and Skin Diseases
- Neuroscience and Neural Engineering
- Mechanical and Optical Resonators
- Advanced Sensor and Energy Harvesting Materials
- Ocular Surface and Contact Lens
- ECG Monitoring and Analysis
- Contact Dermatitis and Allergies
- Acoustic Wave Resonator Technologies
- EEG and Brain-Computer Interfaces
- Analytical Chemistry and Sensors
- Toxin Mechanisms and Immunotoxins
- Force Microscopy Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Immunotherapy and Immune Responses
- Human Rights and Development
- Lipid Membrane Structure and Behavior
- Human-Animal Interaction Studies
- Animal Behavior and Welfare Studies
- Advanced Drug Delivery Systems
- Microfluidic and Capillary Electrophoresis Applications
- Transgenic Plants and Applications
- Photonic and Optical Devices
University College Cork
2016-2025
National University of Ireland
2016-2022
Tyndall Centre
2018
Tyndall National Institute
2010-2017
Baylor College of Medicine
2014
University College London
2012
National Microelectronics Applications Centre (Ireland)
2001-2003
A number of reports have suggested that many the problems currently associated with use microneedle (MN) arrays for transdermal drug delivery could be addressed by using drug-loaded MN prepared moulding hot melts carbohydrate materials.In this study, we explored processing, handling, and storage from galactose a view to clinical application.Galactose required high processing temperature (160 degrees C), molten was difficult work with. Substantial losses model drugs 5-aminolevulinic acid...
This article explores recent advances in the development of electrochemical biosensors on microneedle platforms towards on-device sensing biomarkers present dermal interstitial fluid. The integration a biosensor with platform opens possibility for minimally invasive bio-chemical detection or continuous monitoring within An introduction to fluid is provided placing emphasis sampling methods that have been employed extract and/or sample tissue analysis. We look briefly at technologies used...
Microneedle-based technologies are the subject of intense research and commercial interest for applications in transdermal delivery diagnostics, primarily because their minimally invasive painless nature, which turn could lead to increased patient compliance self-administration. In this paper, a process fabrication arrays hollow silicon microneedles is described. This method uses just two bulk etches - front-side wet etch define 500 μm tall octagonal needle structure itself, rear-side dry...
The use of microneedles as a method circumventing the barrier properties stratum corneum is receiving much attention. Although skin disruption technologies and subsequent transdermal diffusion rates are being extensively studied, no accurate data on depth closure kinetics microneedle-induced pores available, primarily due to cumbersome techniques currently required for analysis. We report first optical coherence tomography technology image microneedle penetration in real time vivo. show that...
Human dignity has been the foundational principle of choice both international human rights law and domestic constitutional provisions since end Second World War. However, in spite widespread agreement on importance principle, there is a significant degree confusion regarding what it demands makers adjudicators, considerable inconsistency its formulation application law. This paper will argue that much this stems from loose usage term by judges commentators. The discussion focus two...
Abstract We present “one‐step application” dissolving and hydrogel‐forming microneedle arrays ( MN ) for enhanced delivery of photosensitizers/precursors. (280 μm) prepared from 20% w/w poly(methylvinylether/maelic acid) cross‐linked with glycerol by esterification to form hydrogels upon skin insertion, or allowed dissolve rapidly in skin, were combined patches containing 19 mg cm −2 5‐aminolevulinic acid ALA meso‐tetra (N‐methyl‐4‐pyridyl) porphine tetra tosylate TMP drug delivery. Both...
The advances in information and communication technologies have been largely predicated around the increases computer processor power derived from constant miniaturization (and consequent higher density) of individual transistors. Transistor design has unchanged for many years progress scaling basic CMOS device. Scaling enabled by photolithography improvements (i.e. patterning) secondary processing such as deposition, implantation, planarization, etc. Perhaps most important processes is...
Background Vaccine delivery into the skin has received renewed interest due to ease of access immune system and microvasculature, however stratum corneum (SC), must be breached for successful vaccination. This been achieved by removing SC abrasion or scarification delivering vaccine intradermally (ID) with traditional needle-and-syringes long microneedle devices. Microneedle patch-based transdermal studies have predominantly focused on antibody induction inactivated subunit vaccines. Here,...
Abstract Biomimetics is the interdisciplinary scientific field focused on study and imitation of biological systems, with aim solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) MN arrays, intended rapidly coating MNs drug/vaccine. The biomimetic approach consists in ornamenting lateral sides pyramidal structures inspired by external scent efferent systems some European true bugs, which facilitate directional liquid transport. To...
Abstract Purpose A dissolving microneedle array (dMNA) is a vaccine delivery device with several advantages over conventional needles. By incorporating particulate adjuvants in the form of poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) into dMNA, immune response against antigen might be enhanced. This study aimed to prepare PLGA-NP-loaded dMNA and compare T-cell responses induced by either intradermally injected aqueous-PLGA-NP formulation or mice. Methods PLGA NPs were...
New approaches to enable more effective management of diabetes mellitus, such as continuous glucose monitoring are being developed both prevent unstable episodes hypo or hyper glycaemia and also provide an improved user experience. One emerging approach realize these requirements is fabricate a minimally invasive transdermal sensor for the direct in vivo detection interstitial fluid. Microneedles – sharp, microscopic structures measuring less than 1 mm length have been previously employed...
The purpose of this study was to optimize the manufacturing dissolving microneedles (dMNs) and increase antigen loading in dMNs investigate effect on their physicochemical properties. To achieve this, a novel single-array wells polydimethylsiloxane mold designed, minimizing wastage during fabrication achieving homogeneous distribution among dMN arrays. Using mold, hyaluronan (HA)-based were fabricated tested for maximal ovalbumin (OVA) content. could be with an OVA:HA ratio as high 1:1...
Electroencephalography (EEG) is an important clinical tool for monitoring neurological health. However, the required equipment, expertise, and patient preparation inhibits its use outside of tertiary care. Non-experts struggle to obtain high-quality EEG due low amplitude artefact susceptibility. Wet electrodes are currently used, which require abrasive/conductive gels reduce skin-electrode impedance. Advances in dry electrodes, do not gels, have simplified this process. assessment on...