A5041759168- Mesenchymal stem cell research
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- MicroRNA in disease regulation
- Immune cells in cancer
- Advancements in Transdermal Drug Delivery
- Blood properties and coagulation
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Advanced Drug Delivery Systems
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Diabetic Foot Ulcer Assessment and Management
- Enhanced Recovery After Surgery
- Trauma Management and Diagnosis
- Hemostasis and retained surgical items
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Lattice Boltzmann Simulation Studies
- Burn Injury Management and Outcomes
- Gut microbiota and health
- Medical Research and Treatments
- Drug Solubulity and Delivery Systems
- Ocular Surface and Contact Lens
Munster Technological University
2021-2023
University College Cork
2014-2020
Mesenchymal stem cells (MSCs) are currently under investigation as tools to preserve cardiac structure and function following acute myocardial infarction (AMI). However, concerns have emerged regarding safety of intracoronary (IC) MSC delivery. This study aimed characterize innate prothrombotic activity identify means its mitigation toward safe efficacious therapeutic IC delivery post-AMI. Expression the initiator coagulation cascade tissue factor (TF) on was detected quantified by...
Microneedle-based technologies are the subject of intense research and commercial interest for applications in transdermal delivery diagnostics, primarily because their minimally invasive painless nature, which turn could lead to increased patient compliance self-administration. In this paper, a process fabrication arrays hollow silicon microneedles is described. This method uses just two bulk etches - front-side wet etch define 500 μm tall octagonal needle structure itself, rear-side dry...
Abstract Biomimetics is the interdisciplinary scientific field focused on study and imitation of biological systems, with aim solving complex technological problems. In this paper, we present a new bio-inspired design for microneedles (MNs) MN arrays, intended rapidly coating MNs drug/vaccine. The biomimetic approach consists in ornamenting lateral sides pyramidal structures inspired by external scent efferent systems some European true bugs, which facilitate directional liquid transport. To...
Abstract Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is potent cytokine involved in the recruitment of macrophages. We hypothesised that MSC derived may be therapeutic effect by facilitating macrophage repolarisation. To further delineate this mechanism, isolated from deficient mice (MSC-KO) were applied to excisional wounds wild-type (WT) mice. deficiency completely abrogated response...
To extend the temporal window for cytoprotection in cardiomyocytes undergoing apoptosis after hypoxia and myocardial infarction (MI), a synthetic chemically modified mRNA (modRNA) was used to drive delivery of insulin-like growth factor-1 (IGF1) within area at risk an vivo murine model MI. Delivery IGF1 modRNA, with polyethylenimine-based nanoparticle, augmented secreted cell-associated IGF1, promoting cardiomyocyte survival abrogating cell under hypoxia-induced conditions. Translation...
<b><i>Background:</i></b> A prolonged inflammatory phase is seen in aberrant wound healing and chronic wounds. Macrophages are central to healing. Distinct macrophage subtypes have differing roles both initial inflammation later tissue repair. Broadly, these cells can be divided into M1 M2 macrophages. proliferation differentiation regulated by colony-stimulating factor 1 (CSF-1) signalling blocked GW2580, a competitive cFMS kinase inhibitor, thereby allowing for...
Metabolic syndrome (MetS) is a composite of cardiometabolic risk factors, including obesity, dyslipidemia, hypertension, and insulin resistance, with range secondary sequelae such as nonalcoholic fatty liver disease diastolic heart failure. This has been identified one the greatest global health challenges 21st century. Herein, we examine whether porcine model diet- mineralocorticoid-induced MetS closely mimics cardiovascular, metabolic, gut microbiota, functional metataxonomic phenotype...
Disorders affecting smooth muscle structure/function may require technologies that can generate large scale, differentiated and contractile cells (SMC) suitable for cell therapy. To date no clonal precursor population provides numbers of SMC in culture has been identified a rodent. Identification such also enhance insight into progenitor fate decisions the relationship between precursors disease states implicate SMC. In this study, we used classic expansion techniques to identify novel...
To extend the temporal window for cytoprotection in cardiomyocytes undergoing apoptosis after hypoxia and myocardial infarction (MI), a synthetic modified RNA (modRNA) was used to drive delivery of insulin-like growth factor-1 (IGF1) within area at risk murine model MI. Transient transfection GFP modRNA as an tracking indicator, with polyethylenimine (PEI)-based nanoparticle, showed efficient derived protein minimum cytotoxicity HL-1 (CM; 44±5%). ModRNA-IGF1 expression secreted levels...
Delivery of slow-release local anesthesia has considerable potential for postoperative analgesia. Fibrin gel shown huge drug delivery, but not been fully investigated the delivery anesthetics nor whether incorporation anesthetic drugs into fibrin alters its mechanical properties.This study aimed to evaluate effects bupivacaine inclusion on and kinetic properties as measured by thromboelastography (TEG).Serial dilutions fibrinogen with thrombin were tested TEG identify optimal concentrations...