A5089832034- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Electrospun Nanofibers in Biomedical Applications
- Coronary Interventions and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Acute Myocardial Infarction Research
- SARS-CoV-2 and COVID-19 Research
- Diabetes Management and Research
- Mesenchymal stem cell research
- Protease and Inhibitor Mechanisms
- Medical Imaging and Pathology Studies
- COVID-19 epidemiological studies
- Vaccine Coverage and Hesitancy
- Diabetes Treatment and Management
- Genetic Associations and Epidemiology
- Immunotherapy and Immune Responses
- Tissue Engineering and Regenerative Medicine
- Atrial Fibrillation Management and Outcomes
- Diabetic Foot Ulcer Assessment and Management
- COVID-19 Clinical Research Studies
- Metabolism, Diabetes, and Cancer
- Angiogenesis and VEGF in Cancer
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Cancer Treatment and Pharmacology
Hamad Medical Corporation
2019-2025
University of Tübingen
2022
Cork University Hospital
2018
Massachusetts General Hospital
2014-2016
Harvard University
2016
University College Cork
2013-2015
Mesenchymal stem cells (MSCs) are currently under investigation as tools to preserve cardiac structure and function following acute myocardial infarction (AMI). However, concerns have emerged regarding safety of intracoronary (IC) MSC delivery. This study aimed characterize innate prothrombotic activity identify means its mitigation toward safe efficacious therapeutic IC delivery post-AMI. Expression the initiator coagulation cascade tissue factor (TF) on was detected quantified by...
Background Electrocardiography is one of the most valuable noninvasive diagnostic tools in determining presence many cardiovascular diseases. Genetic factors are important ECG abnormalities and their link to Genome‐wide association studies polygenic risk scores (PRSs) have been conducted for various traits such as QT interval QRS duration. However, these mainly focused on cohorts European descent. Methods In this cohort study, genome‐wide 6 (RR, PR, corrected [QTc], QRS, JT, P wave duration)...
Aim The combination of anthracyclines ( AC ) and trastuzumab TRZ is highly effective in patients with aggressive HER ‐2 + breast cancer, but has a significant risk cardiotoxicity CT ). Trastuzumab‐induced may be reversible. aim this study was to identify echocardiographic parameters associated recovery left ventricular ejection fraction LVEF who developed after treatment. Methods Results Women newly diagnosed cancer treated followed by monitored serial echocardiograms were retrospectively...
Site specific targeting remains elusive for gene and stem cell therapies in the cardiovascular field. One promising option involves use of devices that deliver larger more sustained cell/gene payloads to disease sites using versatility percutaneous vascular access technology. Smooth muscle cells (SMCs) engineered high local concentrations an angiogenic molecule (VEGF) were placed intravascular delivery device (ICDD) a porcine model chronic total occlusion (CTO) involving ameroid placement on...
Objective: The objective of this study was to assess the effects COVID-19 safety measures on outcomes in patients receiving warfarin for cardiac indications at Heart Hospital’s anticoagulation clinic, Hamad Medical Corporation. Methods: Two cohort surveys were studied: pre-COVID-19 (December 1, 2018, February 28, 2019) and post-COVID-19 (April 2020, June 20, 2020). Collected data included demographics, chronic conditions, indications, clinic visits, efficacy outcomes. Thrombotic events...
An 84-year-old woman was admitted to the hospital because of chest pain, respiratory distress, and a purpuric rash. Initial imaging showed bilateral patchy confluent opacities, finding consistent with pulmonary edema. A diagnostic procedure performed.
Site specific targeting remains an elusive goal for stem cell and gene therapies in the cardiovascular field. One promising option involves use of modified 3D stent designs that deliver larger cell/gene payloads to disease sites using versatility percutaneous vascular access. Here, we engineered smooth muscle cells (SMCs) placed a metallic scaffold high local concentrations angiogenic (VEGF165) porcine model chronic total occlusion involving ameroid placement on proximal left circumflex...
Cell therapy remains an evolving therapeutic option for cardiac repair in the case of acute myocardial infarction (AMI) associated with significant cardiomyocyte death. Mesenchymal stem cells (MSCs) are promising candidates promoting salvage post AMI, but concerns regarding safety intracoronary MSC delivery remain. Surface expression tissue factor (TF), a key initiator soluble coagulation cascade, has recently been implicated as possible cause procoagulant activity. This study aimed to...
Abstract COVID-19 vaccines based on a range of expression platforms have shown considerable protective efficacy, generating antibody and T cell immune responses. However, molecular pathways underpinning vaccine priming immunity against the SARS-CoV-2 virus not yet been explored extensively. This analysis is critical to optimization future vaccination strategies, schedules, combinations. Thus, we investigated cohort individuals pre- post-vaccination understand humoral cellular response...