A5006048374- COVID-19 Clinical Research Studies
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Nutrition and Health in Aging
- Language Development and Disorders
- SARS-CoV-2 and COVID-19 Research
- Meta-analysis and systematic reviews
- Cancer survivorship and care
- Health disparities and outcomes
- Balance, Gait, and Falls Prevention
- Gestational Diabetes Research and Management
- Advanced Causal Inference Techniques
- Long-Term Effects of COVID-19
- Child Nutrition and Water Access
- Pharmaceutical Practices and Patient Outcomes
- SARS-CoV-2 detection and testing
- Nutritional Studies and Diet
- COVID-19 and healthcare impacts
- Male Reproductive Health Studies
- Family and Disability Support Research
- Testicular diseases and treatments
- Drug-Induced Ocular Toxicity
- Statistical Methods in Clinical Trials
University College Cork
2016-2025
Health Research Board
2017-2024
Google (United States)
2024
University Hospital Waterford
2024
University College Dublin
2023
Hokkaido University
2023
Health Protection Surveillance Centre
2023
Children's Health Ireland at Crumlin
2023
Institute of Public Health
2023
Cork University Hospital
2019-2022
To investigate associations between adverse childhood experiences (ACEs) and later-life depressive symptoms; to explore whether perceived social support (PSS) moderates these.We analysed baseline data from the Mitchelstown (Ireland) 2010-2011 cohort of 2047 men women aged 50-69 years. Self-reported measures included ACEs (Centre for Disease Control ACE questionnaire), PSS (Oslo Social Support Scale) symptoms (CES-D). The primary exposure was self-report at least one ACE. We also investigated...
Background: Promoting catch-up growth in malnourished children has health benefits, but recent evidence suggests that accelerated child weight gain increases adult chronic disease risk. Objective: We aimed to determine how birth (BW) and midchildhood relate blood pressure (BP) young adults. Design: pooled data from cohorts Brazil, Guatemala, India, the Philippines, South Africa. used conditional (CW), a residual of current regressed on prior weights, represent deviations expected 0 12, 12...
Multi-morbidity and polypharmacy increase the risk of non-trivial adverse drug reactions (ADRs) in older people during hospitalization. Despite this, there are no established interventions for hospital-acquired ADR prevention.We undertook a pragmatic, multi-national, parallel arm prospective randomized open-label, blinded endpoint (PROBE) controlled trial enrolling patients at six European medical centres. We 1,537 surgical with multi-morbidity on admission 1:1 ratio to SENATOR...
SARS-CoV-2 RNA quantification in wastewater is an important tool for monitoring the prevalence of COVID-19 disease on a community scale which complements case-based surveillance systems. As novel variants concern (VOCs) emerge there also need to identify primary circulating community, accomplished date by sequencing clinical samples. Quantifying offers cost-effective means augment these efforts. In this study, N1 concentrations and daily loadings were determined compared data collected as...
During April-July 2022, outbreaks of severe acute hepatitis unknown etiology (SAHUE) were reported in 35 countries. Five percent cases required liver transplantation, and 22 patients died. Viral metagenomic studies clinical samples from SAHUE showed a correlation with human adenovirus F type 41 (HAdV-F41) adeno-associated virus 2 (AAV2). To explore the association between those DNA viruses children Ireland, we quantified HAdV-F41 AAV2 collected wastewater treatment plant serving 40%...
Abstract Objective To evaluate the efficacy and safety of non‐ablative vaginal Er:YAG laser device in stress urinary incontinence (SUI) treatment. Methods We conducted a multicenter blinded randomized sham‐controlled trial which women with urodynamic SUI were randomization to active arm using therapy, sham handpiece. Patients received two treatments 1 month apart. The primary outcomes measure was h pad weight test measured at 6 months. Secondary durability treatment success 12 months,...
Data-driven approaches to dietary patterns are under-utilized; latent class analyses (LCA) particularly rare. The present study used an LCA identify subgroups of people with similar patterns, explore changes in over a 10-year period and relate these dynamics sociodemographic factors health outcomes.The 1998 baseline 2008 follow-up the Cork Kerry Diabetes Heart Disease Study. Diets were assessed standard FFQ. LCA, under assumption conditional independence, was mutually exclusive different...
<ns3:p>Background In areas of social disadvantage up to 40–50% children enter preschool with speech and language skills significantly poorer than would be expected for their age. The Happy Talk trial tests if a community embedded, targeted selective programme that simultaneously engages parents early childhood educators, (1) improves outcomes in aged between 2 years 10 months 6 (2) is cost effective the health care system. Method large scale cluster randomised 12-week manualised intervention...
Evidence suggests that inactivity during a hospital stay is associated with poor health outcomes in older medical inpatients. We aimed to estimate the associations of average daily step-count (walking) physical performance and length this population.
Objectives Fever is a common symptom of mostly benign illness in young children, yet concerning for parents. The aim this study was to describe parental knowledge, attitudes and beliefs regarding fever children aged ≤5 years age. Design A cross-sectional using previously validated questionnaire. Results were analysed descriptive statistics multivariable logistic regression. Setting Purposively selected primary schools (n=8) Cork, Ireland, paper-based Data collected from internet-based...
Abstract Background To measure the effects of an augmented prescribed exercise programme versus usual care, on physical performance, quality life and healthcare utilisation for frail older medical patients in acute setting. Methods This was a parallel single-blinded randomised controlled trial. Within 2 days admission, inpatients with anticipated length stay ≥3 days, needing assistance/aid to walk, were blindly randomly allocated intervention or control group. Until discharge, both groups...
The aim of this trial is to evaluate the effect SENATOR software on incident, adverse drug reactions (ADRs) in older, multimorbid, hospitalized patients. produces a report designed optimize older patients’ current prescriptions by applying published STOPP and START criteria, highlighting drug-drug drug-disease interactions providing non-pharmacological recommendations aimed at reducing risk incident delirium. We will conduct multinational, pragmatic, parallel arm Prospective Randomized...
In the intravenous iron therapy to treat deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial, use of did not reduce need for blood transfusion or patient complications length hospital stay. As part trial protocol, serum was collected at randomisation and on day surgery. These samples were analysed a central laboratory markers deficiency. We performed secondary analysis explore potential interactions between pre-operative intervention status outcome measures....
To implement and evaluate a Frailty Care Bundle (FCB) targeting mobilisation, nutrition, cognition in older trauma patients to reduce hospital associated decline.
<ns4:p>Background Eight out of ten adults use social media, yet its efficacy in recruitment clinical trials remains under-explored. The purpose this SWAT was to determine which method, X, Facebook or QR code via posters, more efficient and cost effective for recruiting participants the host trial. Methods A cluster randomised cross-over design evaluated three strategies, code. Seven Gaelic Athletic Association (GAA) clubs were receive either Facebook, seven re-randomised twice more, two...
Adverse drug reactions (ADRs) are common in older adults and frequently have serious clinical economic consequences. This study was conducted as a feasibility for randomized control trial (RCT) that will investigate the efficacy of software engine to optimize medications reduce incident (in-hospital) ADRs. study's objectives were (i) establish current ADR rates across six sites participating forthcoming RCT (ii) assess whether ADRs predictable.This multicentre, prospective observational...