A5033527646- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Cardiac, Anesthesia and Surgical Outcomes
- Bone health and osteoporosis research
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Balance, Gait, and Falls Prevention
- Adrenal Hormones and Disorders
- Medication Adherence and Compliance
- Frailty in Older Adults
- Pharmacovigilance and Adverse Drug Reactions
- Health disparities and outcomes
- Global Health Care Issues
- Stress Responses and Cortisol
- Blood Pressure and Hypertension Studies
- Schizophrenia research and treatment
- Intensive Care Unit Cognitive Disorders
- Hip and Femur Fractures
- Insurance, Mortality, Demography, Risk Management
- Menopause: Health Impacts and Treatments
- Chronic Disease Management Strategies
- Circadian rhythm and melatonin
- Patient Safety and Medication Errors
- Bone Metabolism and Diseases
Reykjavík University
2006-2024
National University Hospital of Iceland
2015-2024
University of Iceland
2002-2024
Barnaspítali
2019
NHS Grampian
2017
Icelandic Heart Association
2006
University of Wisconsin–Madison
1997-2003
Geriatric Research Education and Clinical Center
1997-2000
William S. Middleton Memorial Veterans Hospital
1997-1999
Abstract Purpose STOPP/START is a physiological systems-based explicit set of criteria that attempts to define the clinically important prescribing problems relating potentially inappropriate medications (PIMs–STOPP criteria) and potential omissions (PPOs–START criteria). The previous two versions were published in 2008 2015. present study describes revised updated third version criteria. Methods A detailed system-by-system review literature from April 2014 March 2022 was undertaken with aim...
Abstract Background Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier furthermore, there is no consensus on which medications considered as FRIDs despite several systematic reviews. To support clinicians in the management facilitate deprescribing process, STOPPFall (Screening Tool Older Persons Prescriptions older adults with high fall risk) tool were developed by European expert group....
Multi-morbidity and polypharmacy increase the risk of non-trivial adverse drug reactions (ADRs) in older people during hospitalization. Despite this, there are no established interventions for hospital-acquired ADR prevention.We undertook a pragmatic, multi-national, parallel arm prospective randomized open-label, blinded endpoint (PROBE) controlled trial enrolling patients at six European medical centres. We 1,537 surgical with multi-morbidity on admission 1:1 ratio to SENATOR...
The aging of our societies leads to a higher prevalence multimorbidity and therefore polypharmacy, which often results in inappropriate drug treatment. To address this issue, numerous listing approaches, such as the Fit fOR Aged (FORTA) list have been developed. FORTA's positive impact on quality medications relevant clinical outcomes has shown. Based new emerging evidence experiences with existing FORTA lists, we aimed update lists several European countries/regions.Two-step Delphi...
Falls are a major public health concern in the older population, and certain medication classes significant risk factor for falls. However, knowledge is lacking among both physicians people, including caregivers, concerning role of as factor. In present statement, European Geriatric Medicine Society (EuGMS) Task Finish group on fall-risk-increasing drugs (FRIDs), collaboration with EuGMS Special Interest Pharmacology Union Medical Specialists (UEMS) Section, outlines its position regarding...
Abstract Inappropriate polypharmacy is highly prevalent among older adults and presents a significant healthcare concern. Conducting medication reviews implementing deprescribing strategies in multimorbid with are an inherently complex challenging task. Recognizing this, the Special Interest Group on Pharmacology of European Geriatric Medicine Society has compiled evidence review formulated recommendations to enhance appropriate prescribing practices. The current supports need for...
Most studies on pharmacodynamic variables in vitro, including the postantibiotic effect (PAE), are performed at pH 7.4 noncationic-supplemented media, a situation which may differ significantly from true microenvironment most infected foci. We studied impact of five different levels (pH 5, 6, 7, 7.4, and 8) duration PAE, MIC, bactericidal activity. Acid was found to have general deleterious activity aminoglycosides ciprofloxacin against Escherichia coli Pseudomonas aeruginosa, with MIC being...
The aim of this trial is to evaluate the effect SENATOR software on incident, adverse drug reactions (ADRs) in older, multimorbid, hospitalized patients. produces a report designed optimize older patients’ current prescriptions by applying published STOPP and START criteria, highlighting drug-drug drug-disease interactions providing non-pharmacological recommendations aimed at reducing risk incident delirium. We will conduct multinational, pragmatic, parallel arm Prospective Randomized...
To provide an overview of the current deprescribing attitudes, practices, and approaches geriatricians geriatricians-in-training across Europe.An online survey was disseminated among European geriatricians-in-training. The comprised Likert scale multiple-choice questions on education knowledge, facilitators/barriers deprescribing. Responses to participant characteristics were quantified differences evaluated between regions.The 964 respondents (median age 42 years old; 64% female; 21%...
Abstract Background The aim of this study was to determine the prevalence preoperative polypharmacy and incidence postoperative polypharmacy/hyper-polypharmacy in surgical patients their association with adverse outcomes. Methods This a retrospective, population-based cohort among older than or equal 18 years undergoing surgery at university hospital between 2005 2018. Patients were categorized based on number medications: non-polypharmacy (fewer 5); (5–9); hyper-polypharmacy (greater 10)....
Abstract Purpose Adverse drug reactions (ADRs) are a major cause of morbidity and mortality, especially in older people. Older people with diabetes mellitus may be at high risk ADRs but this has not been well studied. This study aimed to compare severity type hospitalised, multimorbid without secondly assess the impact on rehospitalisation length stay. Methods Participants SENATOR (Software Engine for Assessment optimization non-drug Therapy peRsons) trial were assessed 12 common ‘other’...
OBJECTIVE: To assess clinical outcomes and determine whether osteoporosis assessment secondary prevention strategies were performed for male veterans hospitalized hip fractures. DESIGN: Retrospective chart review fracture from January 1993 through July 1999. SETTING: The Veterans Affairs Medical Center, Madison, WI. RESULTS: charts available 46 of 53 patients admitted during the study period. Three subjects excluded because was associated with high-impact trauma. Mean age 43 72 years (range...
Older women experience more adverse drug reactions (ADRs) than older men. However, the underlying basis for this sex difference is unclear. Sex (biological status) and/or gender (sociocultural constructs) influences on patterns of inappropriate prescribing in multimorbid adults may be one reason ADR difference. In secondary analysis, we examined whether incident differences could related to concurrent potentially prescribing.