A5027453724- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Pharmacovigilance and Adverse Drug Reactions
- Medication Adherence and Compliance
- Patient Safety and Medication Errors
- Frailty in Older Adults
- Dental Health and Care Utilization
- Chronic Disease Management Strategies
- Antibiotic Use and Resistance
- Dementia and Cognitive Impairment Research
- Schizophrenia research and treatment
- Stroke Rehabilitation and Recovery
- Blood Pressure and Hypertension Studies
- Balance, Gait, and Falls Prevention
- Pharmacy and Medical Practices
- Acute Ischemic Stroke Management
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare cost, quality, practices
- Heart Failure Treatment and Management
- Nutrition and Health in Aging
- Oral microbiology and periodontitis research
- Cardiovascular Syncope and Autonomic Disorders
- Healthcare Quality and Management
Cork University Hospital
2016-2025
University College Cork
2016-2025
National University of Ireland
2014-2023
University of Bern
2023
Radboud University Nijmegen
2023
Radboud University Medical Center
2023
University Medical Center Utrecht
2023
Utrecht University
2023
Cliniques Universitaires Saint-Luc
2023
UCLouvain
2023
Alterations in the human intestinal microbiota are linked to conditions including inflammatory bowel disease, irritable syndrome, and obesity. The also undergoes substantial changes at extremes of life, infants older people, ramifications which still being explored. We applied pyrosequencing over 40,000 16S rRNA gene V4 region amplicons per subject characterize fecal 161 subjects aged 65 y 9 younger control subjects. each individual constituted a unique profile that was separable from all...
Introduction: STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) is a new, systems-defined medicine review tool. We compared the performance to that established Beers' criteria in detecting medicines (PIMs) and related adverse drug events (ADEs) older patients presenting for hospital admission. Methods: we prospectively studied 715 consecutive acute admissions university teaching hospital. Diagnoses, reason admission concurrent medications were recorded....
<h3>Background</h3> Previous studies have not demonstrated a consistent association between potentially inappropriate medicines (PIMs) in older patients as defined by Beers criteria and avoidable adverse drug events (ADEs). This study aimed to assess whether PIMs new STOPP (Screening Tool of Older Persons' Prescriptions) are significantly associated with ADEs people acute illness. <h3>Methods</h3> We prospectively studied 600 consecutive 65 years or who were admitted illness university...
Inappropriate prescribing is particularly common in older patients and associated with adverse drug events (ADEs), hospitalization, wasteful utilization of resources. We randomized 400 hospitalized aged ≥65 years to receive either the usual pharmaceutical care (control) or screening STOPP/START criteria followed up recommendations their attending physicians (intervention). The Medication Appropriateness Index (MAI) Assessment Underutilization (AOU) index were used assess appropriateness,...
Introduction: Adverse drug events (ADEs) are associated with inappropriate prescribing (IP) and result in increased morbidity, mortality resource utilisation. We used Beers' Criteria to determine the three-month prevalence of IP a non-selected community-dwelling population acutely ill older people requiring hospitalisation. Methods: A prospective, observational study 597 consecutive acute admissions was performed. Diagnoses concurrent medications were recorded before hospital physician...
Abstract Purpose STOPP/START is a physiological systems-based explicit set of criteria that attempts to define the clinically important prescribing problems relating potentially inappropriate medications (PIMs–STOPP criteria) and potential omissions (PPOs–START criteria). The previous two versions were published in 2008 2015. present study describes revised updated third version criteria. Methods A detailed system-by-system review literature from April 2014 March 2022 was undertaken with aim...
Inappropriate prescribing encompasses acts of commission i.e. giving drugs that are contraindicated or unsuitable, and omission failure to prescribe when indicated due ignorance evidence base other irrational basis e.g. ageism. There considerable published data on the prevalence inappropriate prescribing; however, there no recent omission. The aim this study was calculate in a population consecutively hospitalised elderly people.A screening tool (screening alert doctors right treatment...
* Potentially inappropriate prescribing in older people is a well-documented problem and has been associated with adverse drug reactions hospitalization. Beers' criteria, Screening Tool of Older Persons' potentially Prescriptions (STOPP) to Alert doctors Right Treatment (START) are screening tools that have formulated help physicians pharmacists identify potential omissions. The prevalence omissions the elderly population presenting hospital acute illness high according STOPP START...
to validate STOPPFrail, a list of explicit criteria for potentially inappropriate medication (PIM) use in frail older adults with limited life expectancy. Delphi consensus survey an expert panel comprising academic geriatricians, clinical pharmacologists, palliative care physicians, old age psychiatrists, general practitioners and pharmacists. Ireland. seventeen panellists. STOPPFrail were initially created by the authors based on experience literature appraisal. Criteria organised according...
Abstract Background Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier furthermore, there is no consensus on which medications considered as FRIDs despite several systematic reviews. To support clinicians in the management facilitate deprescribing process, STOPPFall (Screening Tool Older Persons Prescriptions older adults with high fall risk) tool were developed by European expert group....
Abstract Objective To examine the effect of optimising drug treatment on related hospital admissions in older adults with multimorbidity and polypharmacy admitted to hospital. Design Cluster randomised controlled trial. Setting 110 clusters inpatient wards within university based hospitals four European countries (Switzerland, Netherlands, Belgium, Republic Ireland) defined by attending doctors. Participants 2008 (≥70 years) (≥3 chronic conditions) (≥5 drugs used long term). Intervention...
Inappropriate prescribing (IP) in older patients is highly prevalent and associated with an increased risk of adverse drug events (ADEs), morbidity, mortality healthcare utilisation. Consequently, IP a major safety concern changing population demographics, it likely to become even more the future. can be detected using explicit or implicit indicators. Theoretically, routine clinical application these criteria could represent inexpensive time efficient method optimise practice. However, must...