A5081433687- Balance, Gait, and Falls Prevention
- Pharmaceutical Practices and Patient Outcomes
- Cerebral Palsy and Movement Disorders
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Blood Pressure and Hypertension Studies
- Musculoskeletal pain and rehabilitation
- Medication Adherence and Compliance
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Stroke Rehabilitation and Recovery
- Hip and Femur Fractures
- Schizophrenia research and treatment
- Electronic Health Records Systems
- Genetic Associations and Epidemiology
- Emergency and Acute Care Studies
- Healthcare Technology and Patient Monitoring
- Injury Epidemiology and Prevention
- Child Nutrition and Feeding Issues
- Patient Safety and Medication Errors
- Genomics and Rare Diseases
- Healthcare Systems and Technology
- Artificial Intelligence in Healthcare and Education
- Delphi Technique in Research
- Nutrition and Health in Aging
University of Amsterdam
2018-2025
Amsterdam University Medical Centers
2019-2025
University Hospital of Umeå
2025
Umeå University
2025
Amsterdam UMC Location University of Amsterdam
2018-2024
Public Health Service of Amsterdam
2023-2024
Abstract Background Healthcare professionals are often reluctant to deprescribe fall-risk-increasing drugs (FRIDs). Lack of knowledge and skills form a significant barrier furthermore, there is no consensus on which medications considered as FRIDs despite several systematic reviews. To support clinicians in the management facilitate deprescribing process, STOPPFall (Screening Tool Older Persons Prescriptions older adults with high fall risk) tool were developed by European expert group....
Abstract Inappropriate polypharmacy is highly prevalent among older adults and presents a significant healthcare concern. Conducting medication reviews implementing deprescribing strategies in multimorbid with are an inherently complex challenging task. Recognizing this, the Special Interest Group on Pharmacology of European Geriatric Medicine Society has compiled evidence review formulated recommendations to enhance appropriate prescribing practices. The current supports need for...
Falls are a major public health concern in the older population, and certain medication classes significant risk factor for falls. However, knowledge is lacking among both physicians people, including caregivers, concerning role of as factor. In present statement, European Geriatric Medicine Society (EuGMS) Task Finish group on fall-risk-increasing drugs (FRIDs), collaboration with EuGMS Special Interest Pharmacology Union Medical Specialists (UEMS) Section, outlines its position regarding...
Abstract Purpose Development of consensus-based recommendations on core and optimal elements orthogeriatric hip-fracture care. Methods An online Delphi survey was performed in the Netherlands. A total 72 statements were derived from a framework encompassing all phases care for older patients with hip fracture. These presented to panelists two rounds identify minimal Panelists included professionals experience patient representatives. The level agreement measured using 5-point Likert scale....
Falls prevention and management in older adults is a critical global challenge. One of the key risk factors for falls use certain medications. Therefore, to prevent medication-related falls, following recommended recent World Guidelines Prevention Management: (1) assess fall history before prescribing potential fall-risk-increasing drugs (FRIDs), (2) validated, structured screening assessment tool identify FRIDs when performing medication review, (3) include review appropriate deprescribing...
Both extrinsic and intrinsic factors predispose older people to fall. We performed a genome-wide association analysis investigate how much of an individual's fall susceptibility can be attributed genetics in 89,076 cases 362,103 controls from the UK Biobank Study. The revealed small, but significant SNP-based heritability (2.7%) identified three novel fall-associated loci (Pcombined ≤ 5 × 10-8). Polygenic risk scores two independent settings showed patterns polygenic inheritance. Risk...
To provide an overview of the current deprescribing attitudes, practices, and approaches geriatricians geriatricians-in-training across Europe.An online survey was disseminated among European geriatricians-in-training. The comprised Likert scale multiple-choice questions on education knowledge, facilitators/barriers deprescribing. Responses to participant characteristics were quantified differences evaluated between regions.The 964 respondents (median age 42 years old; 64% female; 21%...
Falls are the leading cause of injury-related mortality and hospitalization among adults aged ≥ 65 years. An important modifiable fall-risk factor is use increasing drugs (FRIDs). However, deprescribing not always attempted or performed successfully. The ADFICE_IT trial evaluates combined a clinical decision support system (CDSS) patient portal for optimizing FRIDs in older fallers. intervention aims to optimize enhance shared making (SDM) consequently prevent injurious falls reduce...
Worldwide, falls and accompanying injuries are increasingly common, making their prevention management a critical global challenge. The wealth of evidence to support interventions prevent has recently (2022) been distilled in the first World Falls Guideline for Prevention Management Older Adults. core includes (i) risk assessment stratification; (ii) general recommendations on optimising physical function mobility all (iii) offering holistic, multidomain intervention older adults at high...
Abstract Background Use of fall prevention strategies requires detection high-risk patients. Our goal was to develop prediction models for falls and recurrent in community-dwelling older adults improve upon previous by using a large, pooled sample considering wide range candidate predictors, including medications. Methods Harmonized data from 2 Dutch (LASA, B-PROOF) 1 German cohort (ActiFE Ulm) aged ≥65 years were used fit logistic regression models: one predicting any another over year....
OBJECTIVE: This study aims to identify and compare characteristics of hip fracture patients treated non-operatively versus those operatively. METHODS: Design: Retrospective cohort study. Setting: Hip population-based Patient Selection Criteria: All adult with fractures (OTA/AO 31A 31B) were included. Patients pathological or periprosthetic excluded. Outcome Measures Comparisons: categorized according the type management (operative vs non-operative) (nondisplaced other). Patient- associated...
Background/Objectives: Integrated orthogeriatric care has demonstrated benefits in hip fracture management for older patients. Comprehensive pathways are essential effective integrated delivery, yet local variability persists. We assessed the current Netherlands, focusing on between these and degree of implementation care. Methods: A nationwide inventory study was conducted. survey sent to all hospitals Netherlands collect or protocols All elements reported were systematically analyzed by...
Abstract Beta‐blocker usage is inconsistently associated with increased fall risk in the literature. However, due to age‐related changes and interindividual heterogeneity pharmacokinetics dynamics, it difficult predict which older adults are more at for falls. Therefore, we wanted explore whether elevated plasma concentrations of selective nonselective beta‐blockers an falls beta‐blocker users. To answer our research question, analyzed samples (metoprolol, n = 316) (sotalol, timolol,...
Background Antidepressant use has been associated with increased fall risk. Antidepressant-related adverse drug reactions (e.g. orthostatic hypotension) depend partly on genetic variation. We hypothesized that candidate polymorphisms are risk in older antidepressant users. Methods The association between and falls was cross-sectionally investigated a cohort of Dutch adults by logistic regression analyses. In case significant interaction product term polymorphism, the variant genotype...