A5037661131- Balance, Gait, and Falls Prevention
- Schizophrenia research and treatment
- Cardiovascular Syncope and Autonomic Disorders
- Pharmaceutical Practices and Patient Outcomes
- Genetic Associations and Epidemiology
- Cardiovascular Health and Disease Prevention
- Pharmacology and Obesity Treatment
- Stroke Rehabilitation and Recovery
- Heart Rate Variability and Autonomic Control
- Pharmacogenetics and Drug Metabolism
University of Amsterdam
2022-2023
Amsterdam University Medical Centers
2022-2023
Abstract Orthostatic hypotension (OH) is an established and common cardiovascular risk factor for falls. An in-depth understanding of the various interacting pathophysiological pathways contributing to OH-related falls essential guide improvements in diagnostic treatment opportunities. We applied systems thinking multidisciplinary map out causal mechanisms factors. For this, we used group model building (GMB) develop a loop diagram (CLD). The GMB was based on input experts from multiple...
Background Antidepressant use has been associated with increased fall risk. Antidepressant-related adverse drug reactions (e.g. orthostatic hypotension) depend partly on genetic variation. We hypothesized that candidate polymorphisms are risk in older antidepressant users. Methods The association between and falls was cross-sectionally investigated a cohort of Dutch adults by logistic regression analyses. In case significant interaction product term polymorphism, the variant genotype...
Abstract Purpose Antidepressants are well-established fall-risk increasing drugs (FRIDs) and therefore falls should be considered an important adverse drug event (ADE) of antidepressants. However, not all antidepressant users experience fall incidents factors associated with increased risk among incompletely understood. Our objective was to explore whether plasma concentrations in older users. Methods For this study, we included the multicenter B-PROOF study. Fall were recorded prospectively...
Aim Antidepressants are well-established fall-risk increasing drugs(FRIDs) and therefore falls should be considered an important adverse drug event(ADE) of antidepressants. However, not all antidepressant users experience fall incidents factors associated with increased risk among incompletely understood. Our objective was to explore whether plasma concentrations in older users. Methods For this study, we included the multicenter B-PROOF study. Fall were recorded prospectively using...