A5083188322- Lattice Boltzmann Simulation Studies
- Distributed and Parallel Computing Systems
- Blood properties and coagulation
- Cellular Automata and Applications
- Scientific Computing and Data Management
- Parallel Computing and Optimization Techniques
- Aerosol Filtration and Electrostatic Precipitation
- Advanced Data Storage Technologies
- Fluid Dynamics and Vibration Analysis
- Coronary Interventions and Diagnostics
- Fluid Dynamics and Turbulent Flows
- Acute Ischemic Stroke Management
- Theoretical and Computational Physics
- Microfluidic and Bio-sensing Technologies
- Platelet Disorders and Treatments
- Electromagnetic Scattering and Analysis
- Simulation Techniques and Applications
- Generative Adversarial Networks and Image Synthesis
- Erythrocyte Function and Pathophysiology
- Probabilistic and Robust Engineering Design
- Cloud Computing and Resource Management
- Electromagnetic Simulation and Numerical Methods
- Traumatic Brain Injury and Neurovascular Disturbances
- Atmospheric aerosols and clouds
- Digital Holography and Microscopy
University of Amsterdam
2016-2025
Amsterdam University of the Arts
1996-2021
ITMO University
2014-2019
Vrije Universiteit Amsterdam
2016-2019
Centrum Wiskunde & Informatica
2019
Moscow Aviation Institute
2014-2015
Institute of Chemical Kinetics and Combustion
2015
Novosibirsk State University
2007-2015
Moscow Power Engineering Institute
2014
Chalmers University of Technology
2013
We report the results of essentially ab initio simulations creeping flow through large three-dimensional random fiber webs that closely resemble fibrous sheets such as paper and nonwoven fabrics. The computational scheme used in this Letter is lattice-Boltzmann method contains no free parameters concerning properties porous medium or dynamics flow. computed permeability web found to be good agreement with experimental data, confirms depends exponentially on porosity over a range porosity.
We argue that, despite the fact that field of multiscale modelling and simulation has enjoyed significant success within past decade, it still holds many open questions are deemed important but so far have barely been explored. believe this is at least in part due to mainly developed disciplinary silos. The principal topics our view would benefit from a targeted multidisciplinary research effort related reaching consensus as what exactly one means by ‘multiscale modelling’, formulating...
Many of the intriguing properties blood originate from its cellular nature. Therefore, accurate modeling flow related phenomena requires a description dynamics at level individual cells. This, however, presents several computational challenges that can only be addressed by high performance computing. We present Hemocell, parallel computing framework which implements validated mechanical models for red cells and is capable reproducing emergent transport characteristics such complex system. It...
Abstract Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, discover test novel preventive curative therapies, all which warrant experimental models that recapitulate human disease. The translation basic science results clinical practice is challenging task, in particular for complex conditions such as cardiovascular diseases, often result from multiple risk factors comorbidities. This difficulty might lead some...
The role of stagnant zones in hydrodynamic dispersion is studied for creeping flow through a fixed bed spherical permeable particles, covering several orders characteristic time and length scales associated with fluid transport. Numerical simulations employ hierarchical model to cope the different temporal spatial scales, showing good agreement our experimental results on diffusion-limited mass transfer, transient, asymptotic longitudinal dispersion. These data demonstrate that intraparticle...
The inherent complexity of biomedical systems is well recognized; they are multiscale, multiscience systems, bridging a wide range temporal and spatial scales. While the importance multiscale modelling in this context increasingly recognized, there little underpinning literature on methodology generic description process. COAST (complex autonoma simulation technique) project aims to address by developing framework, coined complex (CxA), based hierarchical aggregation coupled cellular...
We review a methodology to design, implement and execute multi-scale multi-science numerical simulations. identify important ingredients of modelling give precise definition them. Our framework assumes that model can be formulated in terms collection coupled single-scale submodels. With concepts such as the scale separation map, generic submodel execution loop (SEL) coupling templates, one define language which is bridge between application design computer implementation. approach has been...
Despite extensive research efforts to mechanistically understand late-onset Alzheimer's disease (LOAD) and other complex mental health disorders, curative treatments remain elusive. We emphasize the multiscale multicausality inherent LOAD, highlighting interplay between interconnected pathophysiological processes risk factors. Systems thinking methods, such as causal loop diagrams systems dynamic models, offer powerful means capture study this complexity. In recent studies, we developed...
The Distributed ASCI Supercomputer (DAS) is a homogeneous wide-area distributed system consisting of four cluster computers at different locations. DAS has been used for research on communication software, parallel languages and programming systems, schedulers, applications, applications. paper gives preview the most interesting results obtained so far in project.
In the present literature on ektacytometry, small angle light scattering by ellipsoidal red blood cells is commonly approximated Fraunhofer diffraction. Calculations a sphere with size and relative refractive index of cell, however, show that diffraction deviates significantly from exact Mie theory. Anomalous found to be much better approximation. The anomalous theory used calculate intensity distribution scattered an ellipsoidally deformed cell. derived expression shows ellipticity...
We compare the discrete dipole approximation (DDA) and finite difference time domain (FDTD) method for simulating light scattering of spheres in a range size parameters x up to 80 refractive indices m 2. Using parallel implementations both methods, we require them reach certain accuracy goal quantities then their performance.We show that relative performance sharply depends on m.The DDA is faster smaller m, while FDTD larger values break-even point lies at = 1.4.We also methods few...
We compared three formulations of the discrete dipole approximation (DDA) for simulation light scattering by particles with refractive indices $m=10+10i$, $0.1+i$, and $1.6+0.01i$. These include filtered coupled dipoles (FCD), lattice dispersion relation (LDR) radiative reaction correction. number iterations required convergence iterative solver (proportional to time) accuracy final results. showed that LDR performance $m=10+10i$ is especially bad, while FCD a good option all cases studied....
We characterize T- and B-lymphocytes from several donors, determining cell diameter, ratio of nucleus to refractive index the cytoplasm for each individual cell. measure light-scattering profiles with a scanning flow cytometer invert signals using coated sphere as an optical model by relying on global optimization technique. The main difference in morphology is found be larger mean diameters latter. However, smaller than natural biological variability single propose nuclear inhomogeneity...
We studied the accuracy of discrete dipole approximation (DDA) for simulations absorption and scattering spectra by gold nanoparticles (spheres, cubes, rods ranging in size from 10 to 100 nm). varied resolution applied two DDA formulations, employing standard lattice dispersion relation (LDR) relatively new filtered coupled dipoles (FCD) approach. The with moderate resolutions is sufficiently accurate efficiencies or positions spectral peaks, but very inaccurate e.g. values near-IR. To keep...
Neointimal hyperplasia, a process of smooth muscle cell re-growth, is the result natural wound healing response injured artery after stent deployment. Excessive neointimal hyperplasia following coronary stenting results in in-stent restenosis (ISR). Regardless recent developments field design, ISR remains significant complication this interventional therapy. The influence design parameters such as strut thickness, shape and depth deployment within vessel wall on severity has already been...