A5007726301- Electrical and Bioimpedance Tomography
- Microfluidic and Bio-sensing Technologies
- Optical Coherence Tomography Applications
- Body Composition Measurement Techniques
- Flow Measurement and Analysis
- Cellular Mechanics and Interactions
- Hemodynamic Monitoring and Therapy
- Mathematical Biology Tumor Growth
- Gastrointestinal motility and disorders
- Advanced Fluorescence Microscopy Techniques
- Research Data Management Practices
- Gene Regulatory Network Analysis
- Wound Healing and Treatments
- Analog and Mixed-Signal Circuit Design
- 3D Printing in Biomedical Research
- Asthma and respiratory diseases
- Photoacoustic and Ultrasonic Imaging
- Non-Invasive Vital Sign Monitoring
- Pelvic floor disorders treatments
- Biomedical and Engineering Education
- Geophysical and Geoelectrical Methods
- Ultrasound Imaging and Elastography
- Cellular Automata and Applications
- Gastroesophageal reflux and treatments
- Inhalation and Respiratory Drug Delivery
University of Sheffield
2008-2019
Portobello High School
2010
Unilever (United Kingdom)
2008
Lancaster University Ghana
2008
Royal Hallamshire Hospital
1994-2005
University of Liverpool
2005
Tabriz University of Medical Sciences
2002
Rotherham General Hospital
1987-2000
University of Caldas
2000
Northern General Hospital
1995
Computational modeling of biological systems, or in silico biology, is an emerging tool for understanding structure and order tissues. models the behavior epithelial cells monolayer cell culture have been developed used to predict healing characteristics scratch wounds made urothelial cultures maintained low- physiological [Ca/sup 2+/] environments. Both computational vitro experiments demonstrated that low exogenous 2+/], closure 500-/spl mu/m was achieved primarily by migration into...
This paper describes the Sheffield Mk3.5 EIT/EIS system which measures both real and imaginary part of impedance at 30 frequencies between 2 kHz 1.6 MHz. The uses eight electrodes with an adjacent drive/receive electrode data acquisition protocol. is modular, containing identical boards, contain DSPs to generate drive perform FFT used for demodulation. current in three sequentially applied packets, where each packet contains ten summed sine waves. interfaced a host PC through optically...
Myoelectrical activity was recorded from the human antrum on 136 occasions using a monopolar mucosal electrode in preoperative and post-vagotomy patients, bipolar serosal electrodes post-cholecystectomy incidence of antral arrhythmias observed. Arrhythmias long duration were observed five out 62 patients after vagotomy one 10 cholecystectomy, but not patients. They characterised by slow waves with increased frequency, variable period, amplitude, wave shape associated periods inhibition. None...
OBJECTIVE--To observe the effects of stimulation sacral anterior roots on anorectal and low colonic pressures to programme implanted stimulators produce defecation. DESIGN--Prospective study 12 consecutive patients. SETTING--Spinal injuries unit university gastrointestinal physiology department. PATIENTS--12 Patients with complete supraconal spinal cord lesions. Their had been sustained at least two years before study. INTERVENTIONS--A Brindley-Finetech intradural root stimulator was in all...
The myoelectrical activity of human colon and rectum has been studied by three types electrode in man--intraluminal (suction), serosal cutaneous. patterns obtained indicate a high degree consistency between the methods value surface electrodes is emphasized. Gradient along large bowel both frequency percentage electrical have observed possible physiological roles are postulated for them. By correlating features regular corresponding motor waves an alteration pattern region rectosigmoid junction.
Transforming Growth Factor (TGF-beta1) is a member of the TGF-beta superfamily ligand-receptor network. and plays crucial role in tissue regeneration. The extensive vitro vivo experimental literature describing its actions nevertheless describe an apparent paradox that during re-epithelialisation it acts as proliferation inhibitor for keratinocytes. majority biological models focus on certain aspects TGF-beta1 behaviour no one model provides comprehensive story this regulatory factor's...
The inherent complexity of biomedical systems is well recognized; they are multiscale, multiscience systems, bridging a wide range temporal and spatial scales. While the importance multiscale modelling in this context increasingly recognized, there little underpinning literature on methodology generic description process. COAST (complex autonoma simulation technique) project aims to address by developing framework, coined complex (CxA), based hierarchical aggregation coupled cellular...
The myoelectrical activity of the rectosigmoid has been studied in 66 subjects at rest and after stimulation with either pentagastrin 6.0 mug/kg hr intravenously 21 cases, neostigmine 0.5 mg intramuscularly 20 or two bisacodyl suppositories 19 cases. Two electrical rhythms were present rest. A faster rhythm (frequency 6-9 cycles/min) predominated its incidence was significantly increased by all levels rectum only. slower 2.5-4.0 which had no effect on rhythm. amplitude each basic rose when...
CITATION: Wolkenhauer, O. et al. 2014. Enabling multiscale modeling in systems medicine. Genome Medicine, 6:21, doi:10.1186/gm538.
Cellular and computational models bronchial biopsies from asthma patients show that a DP 2 antagonist reduces airway smooth muscle mass in asthma.
Two studies concerning multi-frequency impedance measurements are presented. The first uses tetrapolar made on the thorax and second electrical tomography images, also from thorax. way in which changes with ventilation depend upon frequency investigated using Cole-Cole modelling a physiological model of lung tissue. There is an excellent fit to model, results show that it should be possible identify tissue basis spectrum during breathing.
Anorectal manometry and sphincter electromyography were performed in 23 patients with complete supraconal traumatic spinal injuries 30 age sex matched control subjects. Basal pressures the group similar to those normal subjects but conscious of activity was abolished all patients. Discriminant rectal sensation also during distension, 40% experienced a dull pelvic ache at maximum levels distension. Phasic contraction anal relaxation present exaggerated induced lower distending volumes than...
Electrical impedance spectroscopy is a technique that has been investigated as potential method for the diagnosis of epithelial carcinomas. Finite element modelling can provide an insight into patterns current flow in normal and pathological epithelium hence aid process probe design optimization. In order to develop finite model structure precancerous cervical squamous epithelium, it was first necessary obtain mean values ranges number morphological tissue parameters. The most important...
Closely coupled in vitro and virtuo models have been used to explore the self-organization of normal human keratinocytes (NHK). Although it can be observed experimentally, we lack tools many biological rules that govern NHK self-organization. An agent-based computational model was developed, based on derived from literature, which predicts dynamic multicellular morphogenesis a keratinocyte cell line (HaCat cells) under varying extracellular Ca ++ concentrations. The enables exploration...
In vivo and in vitro studies give a paradoxical picture of the actions key regulatory factor TGF-β1 epidermal wound healing with it stimulating migration keratinocytes but also inhibiting their proliferation. To try to reconcile these into an easily visualized 3D model amenable for experimentation by cell biologists, multiscale formation skin epithelium was established literature–derived rule sets equations embedded within it. At cellular level, agent-based bottom-up that focuses on...